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UniProtKB - H7C4E6 (H7C4E6_HUMAN)
Protein
Submitted name:
Phospholipid-transporting ATPase IF
Gene
ATP11B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATPase-coupled intramembrane lipid transporter activity Source: UniProtKB-EC
- ATP binding Source: InterPro
- ATP hydrolysis activity Source: InterPro
GO - Biological processi
- aminophospholipid transport Source: InterPro
Keywordsi
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Phospholipid-transporting ATPase IF |
Gene namesi | Name:ATP11B |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13553, ATP11B |
VEuPathDBi | HostDB:ENSG00000058063 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- endomembrane system Source: UniProt
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 98 – 119 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 125 – 146 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 176 – 198 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 210 – 234 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
MaxQBi | H7C4E6 |
PeptideAtlasi | H7C4E6 |
PRIDEi | H7C4E6 |
ProteomicsDBi | 45648 |
Expressioni
Gene expression databases
Bgeei | ENSG00000058063, Expressed in stomach and 251 other tissues |
ExpressionAtlasi | H7C4E6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 121 – 237 | PhoLip_ATPase_CInterPro annotationAdd BLAST | 117 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156162 |
HOGENOMi | CLU_088375_0_0_1 |
Family and domain databases
Gene3Di | 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030362, ATP11B IPR023298, ATPase_P-typ_TM_dom_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR001757, P_typ_ATPase IPR032630, P_typ_ATPase_c |
PANTHERi | PTHR24092:SF57, PTHR24092:SF57, 1 hit |
Pfami | View protein in Pfam PF16212, PhoLip_ATPase_C, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01494, ATPase_P-type, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
H7C4E6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GTSLSLALRE HEKLFMEVCR NCSAVLCCRM APLQKAKVIR LIKISPEKPI
60 70 80 90 100
TLAVGDGAND VSMIQEAHVG IGIMGKEGRQ AARNSDYAIA RFKFLSKLLF
110 120 130 140 150
VHGHFYYIRI ATLVQYFFYK TLYDSVYLTL YNICFTSLPI LIYSLLEQHV
160 170 180 190 200
DPHVLQNKPT LYRDISKNRL LSIKTFLYWT ILGFSHAFIF FFGSYLLIGK
210 220 230
DTSLLGNGQM FGNWTFGTLV FTVMVITVTV KMALETHF
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9Y2G3 | AT11B_HUMAN | Phospholipid-transporting ATPase IF | ATP11B ATPIF, ATPIR, KIAA0956 | 1,177 | Annotation score: | ||
H7C4W6 | H7C4W6_HUMAN | Phospholipid-transporting ATPase | ATP11B | 970 | Annotation score: | ||
A0A0C4DG94 | A0A0C4DG94_HUMAN | Phospholipid-transporting ATPase IF | ATP11B | 195 | Annotation score: | ||
H0Y8C7 | H0Y8C7_HUMAN | Phospholipid-transporting ATPase IF | ATP11B | 147 | Annotation score: | ||
H7C575 | H7C575_HUMAN | Phospholipid-transporting ATPase IF | ATP11B | 119 | Annotation score: | ||
H0Y854 | H0Y854_HUMAN | Phospholipid-transporting ATPase IF | ATP11B | 108 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Non-terminal residuei | 238 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC069431 Genomic DNA No translation available. AC092953 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000482070.1; ENSP00000417124.1; ENSG00000058063.16 |
UCSCi | uc062qmq.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC069431 Genomic DNA No translation available. AC092953 Genomic DNA No translation available. |
3D structure databases
SMRi | H7C4E6 |
ModBasei | Search... |
Proteomic databases
MaxQBi | H7C4E6 |
PeptideAtlasi | H7C4E6 |
PRIDEi | H7C4E6 |
ProteomicsDBi | 45648 |
Protocols and materials databases
Antibodypediai | 33765, 135 antibodies from 30 providers |
Genome annotation databases
Ensembli | ENST00000482070.1; ENSP00000417124.1; ENSG00000058063.16 |
UCSCi | uc062qmq.1, human |
Organism-specific databases
HGNCi | HGNC:13553, ATP11B |
OpenTargetsi | ENSG00000058063 |
VEuPathDBi | HostDB:ENSG00000058063 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156162 |
HOGENOMi | CLU_088375_0_0_1 |
Miscellaneous databases
ChiTaRSi | ATP11B, human |
Gene expression databases
Bgeei | ENSG00000058063, Expressed in stomach and 251 other tissues |
ExpressionAtlasi | H7C4E6, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030362, ATP11B IPR023298, ATPase_P-typ_TM_dom_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR001757, P_typ_ATPase IPR032630, P_typ_ATPase_c |
PANTHERi | PTHR24092:SF57, PTHR24092:SF57, 1 hit |
Pfami | View protein in Pfam PF16212, PhoLip_ATPase_C, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01494, ATPase_P-type, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H7C4E6_HUMAN | |
Accessioni | H7C4E6Primary (citable) accession number: H7C4E6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | May 25, 2022 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |