UniProtKB - H7C3Q2 (H7C3Q2_HUMAN)
Protein
Submitted name:
E3 ubiquitin-protein ligase HECW1
Gene
HECW1
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- ubiquitin-protein transferase activity Source: InterPro
Keywordsi
Biological process | Ubl conjugation pathwayPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: E3 ubiquitin-protein ligase HECW1Imported |
Gene namesi | Name:HECW1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:22195, HECW1 |
VEuPathDBi | HostDB:ENSG00000002746.14 |
Expressioni
Gene expression databases
Bgeei | ENSG00000002746, Expressed in middle temporal gyrus and 145 other tissues |
ExpressionAtlasi | H7C3Q2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 138 | HECTInterPro annotationAdd BLAST | 74 |
Phylogenomic databases
GeneTreei | ENSGT00940000158294 |
HOGENOMi | CLU_1869799_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase |
Pfami | View protein in Pfam PF00632, HECT, 1 hit |
SUPFAMi | SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50237, HECT, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
H7C3Q2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XPRIPLQNGR LPNHLTHRQH LQRLRSYSAG EARVQWCDLG SLQPPPPRFK
60 70 80 90 100
QFSCLSLSSS WDYRFRFSGR ILGLALIHQY LLDAFFTRPF YKALLRLPCD
110 120 130
LSDLEYLDEE FHQSLQWMKD NNITDILDLT FTVNEEVF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ76N89 | HECW1_HUMAN | E3 ubiquitin-protein ligase HECW1 | HECW1 KIAA0322, NEDL1 | 1,606 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 138 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004455 Genomic DNA No translation available. AC004692 Genomic DNA No translation available. AC005537 Genomic DNA No translation available. AC006365 Genomic DNA No translation available. AC011738 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000429529; ENSP00000413336; ENSG00000002746 |
UCSCi | uc064dco.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004455 Genomic DNA No translation available. AC004692 Genomic DNA No translation available. AC005537 Genomic DNA No translation available. AC006365 Genomic DNA No translation available. AC011738 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | H7C3Q2 |
PRIDEi | H7C3Q2 |
ProteomicsDBi | 45408 |
Protocols and materials databases
Antibodypediai | 1996, 44 antibodies |
Genome annotation databases
Ensembli | ENST00000429529; ENSP00000413336; ENSG00000002746 |
UCSCi | uc064dco.1, human |
Organism-specific databases
HGNCi | HGNC:22195, HECW1 |
OpenTargetsi | ENSG00000002746 |
VEuPathDBi | HostDB:ENSG00000002746.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158294 |
HOGENOMi | CLU_1869799_0_0_1 |
Miscellaneous databases
ChiTaRSi | HECW1, human |
Gene expression databases
Bgeei | ENSG00000002746, Expressed in middle temporal gyrus and 145 other tissues |
ExpressionAtlasi | H7C3Q2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase |
Pfami | View protein in Pfam PF00632, HECT, 1 hit |
SUPFAMi | SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50237, HECT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H7C3Q2_HUMAN | |
Accessioni | H7C3Q2Primary (citable) accession number: H7C3Q2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | October 5, 2016 | |
Last modified: | February 10, 2021 | |
This is version 57 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |