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Protein
Submitted name:

Histone-lysine N-methyltransferase, H3 lysine-79-specific

Gene

DOT1L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Names & Taxonomyi

Protein namesi
Submitted name:
Histone-lysine N-methyltransferase, H3 lysine-79-specificImported
Gene namesi
Name:DOT1LImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104885.17
HGNCiHGNC:24948 DOT1L

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104885

Expressioni

Gene expression databases

BgeeiENSG00000104885 Expressed in 144 organ(s), highest expression level in testis
ExpressionAtlasiH7C3N3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7C3N3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3924 Eukaryota
ENOG410XSYC LUCA
GeneTreeiENSGT00390000013515

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

H7C3N3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GPFPPGPQFA LGPMSLQANL GSVAGSSVLQ SLFSSVPAAA GLVHVSSAAT
60 70 80 90 100
RLTNSHAMGS FSGVAGGTVG GVFNHAVPSA SAHPFGARVG RGAACGSATL
110 120
GPSPLQAAAS ASASSFQAPA SVETR
Length:125
Mass (Da):11,886
Last modified:April 18, 2012 - v1
Checksum:i4410E37DA7E42C76
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8TEK3DOT1L_HUMAN
Histone-lysine N-methyltransferase,...
DOT1L KIAA1814, KMT4
1,537Annotation score:
C9JH95C9JH95_HUMAN
Histone-lysine N-methyltransferase,...
DOT1L
208Annotation score:
V9GY76V9GY76_HUMAN
Histone-lysine N-methyltransferase,...
DOT1L
142Annotation score:
H7C2S2H7C2S2_HUMAN
Histone-lysine N-methyltransferase,...
DOT1L
653Annotation score:
A0A087X1A7A0A087X1A7_HUMAN
Histone-lysine N-methyltransferase,...
DOT1L
69Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei125Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004490 Genomic DNA No translation available.
AC005257 Genomic DNA No translation available.
AC005263 Genomic DNA No translation available.
AC093456 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000446286; ENSP00000412916; ENSG00000104885
UCSCiuc060rit.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004490 Genomic DNA No translation available.
AC005257 Genomic DNA No translation available.
AC005263 Genomic DNA No translation available.
AC093456 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH7C3N3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000446286; ENSP00000412916; ENSG00000104885
UCSCiuc060rit.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000104885.17
HGNCiHGNC:24948 DOT1L
OpenTargetsiENSG00000104885
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3924 Eukaryota
ENOG410XSYC LUCA
GeneTreeiENSGT00390000013515

Miscellaneous databases

ChiTaRSiDOT1L human

Gene expression databases

BgeeiENSG00000104885 Expressed in 144 organ(s), highest expression level in testis
ExpressionAtlasiH7C3N3 baseline and differential

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiH7C3N3_HUMAN
AccessioniPrimary (citable) accession number: H7C3N3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 12, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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