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UniProtKB - H7C3L2 (H7C3L2_HUMAN)
Protein
Submitted name:
D-2-hydroxyglutarate dehydrogenase, mitochondrial
Gene
D2HGDH
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
FADARBA annotation
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
- oxidoreductase activity Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: D-2-hydroxyglutarate dehydrogenase, mitochondrial |
Gene namesi | Name:D2HGDH |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28358, D2HGDH |
VEuPathDBi | HostDB:ENSG00000180902 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180902, Expressed in right uterine tube and 194 other tissues |
ExpressionAtlasi | H7C3L2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 45 | FAD_binding_4InterPro annotationAdd BLAST | 45 |
Phylogenomic databases
GeneTreei | ENSGT00550000075086 |
HOGENOMi | CLU_2460471_0_0_1 |
Family and domain databases
Gene3Di | 3.30.43.10, 1 hit |
InterProi | View protein in InterPro IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR006094, Oxid_FAD_bind_N |
Pfami | View protein in Pfam PF01565, FAD_binding_4, 1 hit |
SUPFAMi | SSF56176, SSF56176, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
H7C3L2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
RHCHERNLAV NPQGGNTGMV GGSVPVFDEI ILSTARMNRV LSFHSVSGCP
60 70 80
GFAEVLQTFS TCKGMLGEIL SAFEFMDAVC MQLVGRHLH
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8N465 | D2HDH_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH D2HGD | 521 | Annotation score: | ||
F8WCF9 | F8WCF9_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH | 243 | Annotation score: | ||
B5MCV2 | B5MCV2_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH | 387 | Annotation score: | ||
G5E9E8 | G5E9E8_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH hCG_31745 | 320 | Annotation score: | ||
H7C021 | H7C021_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH | 152 | Annotation score: | ||
H7C0N1 | H7C0N1_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH | 189 | Annotation score: | ||
H7C290 | H7C290_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH | 78 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Non-terminal residuei | 89 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC114730 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000437164.1; ENSP00000412511.1; ENSG00000180902.18 |
UCSCi | uc061utt.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC114730 Genomic DNA No translation available. |
3D structure databases
SMRi | H7C3L2 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | H7C3L2 |
ProteomicsDBi | 45368 |
Protocols and materials databases
Antibodypediai | 34576, 113 antibodies from 18 providers |
Genome annotation databases
Ensembli | ENST00000437164.1; ENSP00000412511.1; ENSG00000180902.18 |
UCSCi | uc061utt.1, human |
Organism-specific databases
HGNCi | HGNC:28358, D2HGDH |
OpenTargetsi | ENSG00000180902 |
VEuPathDBi | HostDB:ENSG00000180902 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00550000075086 |
HOGENOMi | CLU_2460471_0_0_1 |
Miscellaneous databases
ChiTaRSi | D2HGDH, human |
Gene expression databases
Bgeei | ENSG00000180902, Expressed in right uterine tube and 194 other tissues |
ExpressionAtlasi | H7C3L2, baseline and differential |
Family and domain databases
Gene3Di | 3.30.43.10, 1 hit |
InterProi | View protein in InterPro IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR006094, Oxid_FAD_bind_N |
Pfami | View protein in Pfam PF01565, FAD_binding_4, 1 hit |
SUPFAMi | SSF56176, SSF56176, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H7C3L2_HUMAN | |
Accessioni | H7C3L2Primary (citable) accession number: H7C3L2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | October 5, 2016 | |
Last modified: | May 25, 2022 | |
This is version 61 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |