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Protein
Submitted name:

Cyclic AMP-responsive element-binding protein 1

Gene

CREB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclic AMP-responsive element-binding protein 1Imported
Gene namesi
Name:CREB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000118260.14
HGNCiHGNC:2345 CREB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118260

PTM / Processingi

Proteomic databases

MaxQBiH7C3I0
PeptideAtlasiH7C3I0
PRIDEiH7C3I0

Expressioni

Gene expression databases

BgeeiENSG00000118260 Expressed in 242 organ(s), highest expression level in lung
ExpressionAtlasiH7C3I0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7C3I0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 93KIDInterPro annotationAdd BLAST60

Phylogenomic databases

eggNOGiKOG3584 Eukaryota
ENOG410ZZJZ LUCA
GeneTreeiENSGT00390000008655

Family and domain databases

InterProiView protein in InterPro
IPR003102 Coactivator_CBP_pKID
IPR029802 CREB1
IPR001630 Leuzip_CREB
PANTHERiPTHR22952:SF200 PTHR22952:SF200, 1 hit
PfamiView protein in Pfam
PF02173 pKID, 1 hit
PRINTSiPR00041 LEUZIPPRCREB
PROSITEiView protein in PROSITE
PS50953 KID, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

H7C3I0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XVIQAAQPSV IQSPQVQTVQ SSCKDLKRLF SGTQISTIAE SEDSQESVDS
60 70 80 90 100
VTDSQKRREI LSRRPSYRKI LNDLSSDAPG VPRIEEEKSE EETSAPAITT
110 120 130 140 150
VTVPTPIYQT SSGQYIAITQ GGAIQLANNG TDGVQGLQTL TMTNAAATQP
160 170 180
GTTILQYAQT TDGQQILVPS NQVVVQGTQK L
Length:181
Mass (Da):19,360
Last modified:April 18, 2012 - v1
Checksum:i5DF91BC8F1C82314
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P16220CREB1_HUMAN
Cyclic AMP-responsive element-bindi...
CREB1
341Annotation score:
C9JBT4C9JBT4_HUMAN
Cyclic AMP-responsive element-bindi...
CREB1
170Annotation score:
C9J896C9J896_HUMAN
Cyclic AMP-responsive element-bindi...
CREB1
251Annotation score:
E7EWP8E7EWP8_HUMAN
Cyclic AMP-responsive element-bindi...
CREB1
182Annotation score:
C9J4L5C9J4L5_HUMAN
Cyclic AMP-responsive element-bindi...
CREB1
131Annotation score:
H7C1R5H7C1R5_HUMAN
Cyclic AMP-responsive element-bindi...
CREB1
140Annotation score:
C9J276C9J276_HUMAN
Cyclic AMP-responsive element-bindi...
CREB1
132Annotation score:
C9JCI4C9JCI4_HUMAN
Cyclic AMP-responsive element-bindi...
CREB1
79Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009298 Genomic DNA No translation available.
AC079767 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000418081; ENSP00000412016; ENSG00000118260
UCSCiuc061rvl.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009298 Genomic DNA No translation available.
AC079767 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH7C3I0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH7C3I0
PeptideAtlasiH7C3I0
PRIDEiH7C3I0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418081; ENSP00000412016; ENSG00000118260
UCSCiuc061rvl.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000118260.14
HGNCiHGNC:2345 CREB1
OpenTargetsiENSG00000118260
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3584 Eukaryota
ENOG410ZZJZ LUCA
GeneTreeiENSGT00390000008655

Miscellaneous databases

ChiTaRSiCREB1 human

Gene expression databases

BgeeiENSG00000118260 Expressed in 242 organ(s), highest expression level in lung
ExpressionAtlasiH7C3I0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR003102 Coactivator_CBP_pKID
IPR029802 CREB1
IPR001630 Leuzip_CREB
PANTHERiPTHR22952:SF200 PTHR22952:SF200, 1 hit
PfamiView protein in Pfam
PF02173 pKID, 1 hit
PRINTSiPR00041 LEUZIPPRCREB
PROSITEiView protein in PROSITE
PS50953 KID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH7C3I0_HUMAN
AccessioniPrimary (citable) accession number: H7C3I0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 12, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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