Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Neurexin-2

Gene

NRXN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-2Imported
Gene namesi
Name:NRXN2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110076.18
HGNCiHGNC:8009 NRXN2

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110076

PTM / Processingi

Proteomic databases

PeptideAtlasiH7C2R8
PRIDEiH7C2R8

Expressioni

Gene expression databases

BgeeiENSG00000110076 Expressed in 160 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiH7C2R8 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7C2R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 230LAM_G_DOMAINInterPro annotationAdd BLAST179

Phylogenomic databases

GeneTreeiENSGT00760000118991

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
IPR037440 Neurexin
PANTHERiPTHR44287 PTHR44287, 2 hits
PfamiView protein in Pfam
PF02210 Laminin_G_2, 1 hit
SMARTiView protein in SMART
SM00282 LamG, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50025 LAM_G_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

H7C2R8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LLLLLLGAAE GARVSSSLST THHVHHFHSK HGTVPIAINR MPFLTRGGHA
60 70 80 90 100
GTTYIFGKGG ALITYTWPPN DRPSTRMDRL AVGFSTHQRS AVLVRVDSAS
110 120 130 140 150
GLGDYLQLHI DQGTVGVIFN VGTDDITIDE PNAIVSDGKY HVVRFTRSGG
160 170 180 190 200
NATLQVDSWP VNERYPAGRQ LTIFNSQAAI KIGGRDQGRP FQGQVSGLYY
210 220 230 240 250
NGLKVLALAA ESDPNVRTEG HLRLVGEGPS VLLSAETTAT TLLADMATTI
260 270
METTTTMATT TTRRGRSPTL RDSTTQ
Length:276
Mass (Da):29,663
Last modified:April 18, 2012 - v1
Checksum:iB9C9402F4519D465
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9P2S2NRX2A_HUMAN
Neurexin-2
NRXN2 KIAA0921
1,712Annotation score:
G5E9G7G5E9G7_HUMAN
Neurexin 2, isoform CRA_a
NRXN2 hCG_1810991
1,705Annotation score:
H7C3D6H7C3D6_HUMAN
Neurexin-2
NRXN2
206Annotation score:
H7BZC7H7BZC7_HUMAN
Neurexin-2
NRXN2
292Annotation score:
H7C3J4H7C3J4_HUMAN
Neurexin-2
NRXN2
215Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei276Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001092 Genomic DNA No translation available.
AP001462 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000423049; ENSP00000407374; ENSG00000110076
UCSCiuc058cye.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001092 Genomic DNA No translation available.
AP001462 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH7C2R8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH7C2R8
PRIDEiH7C2R8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423049; ENSP00000407374; ENSG00000110076
UCSCiuc058cye.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000110076.18
HGNCiHGNC:8009 NRXN2
OpenTargetsiENSG00000110076
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118991

Miscellaneous databases

ChiTaRSiNRXN2 human

Gene expression databases

BgeeiENSG00000110076 Expressed in 160 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiH7C2R8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
IPR037440 Neurexin
PANTHERiPTHR44287 PTHR44287, 2 hits
PfamiView protein in Pfam
PF02210 Laminin_G_2, 1 hit
SMARTiView protein in SMART
SM00282 LamG, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50025 LAM_G_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH7C2R8_HUMAN
AccessioniPrimary (citable) accession number: H7C2R8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 12, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again