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Entry version 67 (07 Oct 2020)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Chromodomain-helicase-DNA-binding protein 3

Gene

CHD3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorARBA annotation, HelicaseARBA annotation, Hydrolase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Chromodomain-helicase-DNA-binding protein 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHD3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170004.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1918, CHD3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    NucleusARBA annotation

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    Open Targets

    More...
    OpenTargetsi
    ENSG00000170004

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    H7C2H0

    PeptideAtlas

    More...
    PeptideAtlasi
    H7C2H0

    PRoteomics IDEntifications database

    More...
    PRIDEi
    H7C2H0

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    44985

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000170004, Expressed in cortical plate and 227 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    H7C2H0, baseline and differential

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini250 – 297PHD-typeInterPro annotationAdd BLAST48
    Domaini327 – 374PHD-typeInterPro annotationAdd BLAST48
    Domaini407 – 464ChromoInterPro annotationAdd BLAST58
    Domaini502 – 525ChromoInterPro annotationAdd BLAST24

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni106 – 230DisorderedSequence analysisAdd BLAST125
    Regioni302 – 321DisorderedSequence analysisAdd BLAST20
    Regioni394 – 413DisorderedSequence analysisAdd BLAST20
    Regioni459 – 481DisorderedSequence analysisAdd BLAST23

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi111 – 127Pro-richSequence analysisAdd BLAST17
    Compositional biasi137 – 165BasicSequence analysisAdd BLAST29
    Compositional biasi304 – 321AcidicSequence analysisAdd BLAST18

    Keywords - Domaini

    Zinc-fingerPROSITE-ProRule annotation

    Phylogenomic databases

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000158001

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_035576_0_0_1

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.30.10, 1 hit
    3.30.40.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR012958, CHD_N
    IPR016197, Chromo-like_dom_sf
    IPR000953, Chromo/chromo_shadow_dom
    IPR023780, Chromo_domain
    IPR036910, HMG_box_dom_sf
    IPR019786, Zinc_finger_PHD-type_CS
    IPR011011, Znf_FYVE_PHD
    IPR001965, Znf_PHD
    IPR019787, Znf_PHD-finger
    IPR013083, Znf_RING/FYVE/PHD

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF08073, CHDNT, 1 hit
    PF00385, Chromo, 1 hit
    PF00628, PHD, 2 hits

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00298, CHROMO, 1 hit
    SM00249, PHD, 2 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47095, SSF47095, 1 hit
    SSF54160, SSF54160, 2 hits
    SSF57903, SSF57903, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50013, CHROMO_2, 2 hits
    PS01359, ZF_PHD_1, 1 hit
    PS50016, ZF_PHD_2, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

    This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

    H7C2H0-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    XQKQVEQKSS ATLLLTWGLE DVEHVFSEED YHTLTNYKAF SQFMRPLIAK
    60 70 80 90 100
    KNPKIPMSKM MTILGAKWRE FSANNPFKGS AAAVAAAAAA AAAAVAEQVS
    110 120 130 140 150
    AAVSSATPIA PSGPPALPPP PAADIQPPPI RRAKTKEGKG PGHKRRSKSP
    160 170 180 190 200
    RVPDGRKKLR GKKMAPLKIK LGLLGGKRKK GGSSDEGPEP EAEESDLDSG
    210 220 230 240 250
    SVHSASGRPD GPVRTKKLKR GRPGRKKKKV LGCPAVAGEE EVDGYETDHQ
    260 270 280 290 300
    DYCEVCQQGG EIILCDTCPR AYHLVCLDPE LDRAPEGKWS CPHCEKEGVQ
    310 320 330 340 350
    WEAKEEEEEY EEEGEEEGEK EEEDDHMEYC RVCKDGGELL CCDACISSYH
    360 370 380 390 400
    IHCLNPPLPD IPNGEWLCPR CTCPVLKGRV QKILHWRWGE PPVAVPAPQQ
    410 420 430 440 450
    ADGNPDVPPP RPLQGRSERE FFVKWVGLSY WHCSWAKELQ LEIFHLVMYR
    460 470 480 490 500
    NYQRKNDMDE PPPLDYGSGE DDGKSDKRKV KDPHYAEMEE KYYRFGIKPE
    510 520
    WMTVHRIINH SVDKKGNYHY LVKWR
    Length:525
    Mass (Da):58,868
    Last modified:April 18, 2012 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23DDD7B614B8513B
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    Q12873CHD3_HUMAN
    Chromodomain-helicase-DNA-binding p...
    CHD3
    2,000Annotation score:

    Annotation score:5 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A5F9ZHX5A0A5F9ZHX5_HUMAN
    DNA helicase
    CHD3
    1,357Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C0J3H7C0J3_HUMAN
    Chromodomain-helicase-DNA-binding p...
    CHD3
    383Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C3H7H7C3H7_HUMAN
    Chromodomain-helicase-DNA-binding p...
    CHD3
    277Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A5F9ZHM2A0A5F9ZHM2_HUMAN
    Chromodomain-helicase-DNA-binding p...
    CHD3
    188Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L229I3L229_HUMAN
    Chromodomain-helicase-DNA-binding p...
    CHD3
    249Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L1I4I3L1I4_HUMAN
    Chromodomain-helicase-DNA-binding p...
    CHD3
    110Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EPV1K7EPV1_HUMAN
    Chromodomain-helicase-DNA-binding p...
    CHD3
    63Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
    Non-terminal residuei525Imported1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AC104581 Genomic DNA No translation available.
    KF456246 Genomic DNA No translation available.

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000452447; ENSP00000405861; ENSG00000170004

    UCSC genome browser

    More...
    UCSCi
    uc060awf.1, human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC104581 Genomic DNA No translation available.
    KF456246 Genomic DNA No translation available.

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Proteomic databases

    MaxQBiH7C2H0
    PeptideAtlasiH7C2H0
    PRIDEiH7C2H0
    ProteomicsDBi44985

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    12273, 287 antibodies

    Genome annotation databases

    EnsembliENST00000452447; ENSP00000405861; ENSG00000170004
    UCSCiuc060awf.1, human

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000170004.16
    HGNCiHGNC:1918, CHD3
    OpenTargetsiENSG00000170004

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    GeneTreeiENSGT00940000158001
    HOGENOMiCLU_035576_0_0_1

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    CHD3, human

    Gene expression databases

    BgeeiENSG00000170004, Expressed in cortical plate and 227 other tissues
    ExpressionAtlasiH7C2H0, baseline and differential

    Family and domain databases

    Gene3Di1.10.30.10, 1 hit
    3.30.40.10, 2 hits
    InterProiView protein in InterPro
    IPR012958, CHD_N
    IPR016197, Chromo-like_dom_sf
    IPR000953, Chromo/chromo_shadow_dom
    IPR023780, Chromo_domain
    IPR036910, HMG_box_dom_sf
    IPR019786, Zinc_finger_PHD-type_CS
    IPR011011, Znf_FYVE_PHD
    IPR001965, Znf_PHD
    IPR019787, Znf_PHD-finger
    IPR013083, Znf_RING/FYVE/PHD
    PfamiView protein in Pfam
    PF08073, CHDNT, 1 hit
    PF00385, Chromo, 1 hit
    PF00628, PHD, 2 hits
    SMARTiView protein in SMART
    SM00298, CHROMO, 1 hit
    SM00249, PHD, 2 hits
    SUPFAMiSSF47095, SSF47095, 1 hit
    SSF54160, SSF54160, 2 hits
    SSF57903, SSF57903, 1 hit
    PROSITEiView protein in PROSITE
    PS50013, CHROMO_2, 2 hits
    PS01359, ZF_PHD_1, 1 hit
    PS50016, ZF_PHD_2, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH7C2H0_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H7C2H0
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 7, 2020
    This is version 67 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Proteomics identificationCombined sources, Reference proteomeImported
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