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UniProtKB - H7C2G2 (H7C2G2_HUMAN)
Protein
NAD(P)(+)--arginine ADP-ribosyltransferase
Gene
ART4
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- L-arginyl-[protein] + NAD+ = H+ + Nω-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamideUniRule annotationARBA annotationEC:2.4.2.31UniRule annotationARBA annotation
GO - Molecular functioni
- NAD+-protein-arginine ADP-ribosyltransferase activity Source: UniProtKB-EC
- NADP+-protein-arginine ADP-ribosyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- protein ADP-ribosylation Source: InterPro
Keywordsi
Molecular function | GlycosyltransferaseUniRule annotation, Transferase |
Ligand | NADUniRule annotation, NADPUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: NAD(P)(+)--arginine ADP-ribosyltransferaseUniRule annotation (EC:2.4.2.31UniRule annotation)Alternative name(s): Mono(ADP-ribosyl)transferaseUniRule annotation |
Gene namesi | Name:ART4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:726, ART4 |
VEuPathDBi | HostDB:ENSG00000111339 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | UniRule annotationAdd BLAST | 29 | |
ChainiPRO_5005134628 | 30 – 273 | NAD(P)(+)--arginine ADP-ribosyltransferaseUniRule annotationAdd BLAST | 244 |
Proteomic databases
PeptideAtlasi | H7C2G2 |
PRIDEi | H7C2G2 |
ProteomicsDBi | 44977 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111339, Expressed in amniotic fluid and 112 other tissues |
ExpressionAtlasi | H7C2G2, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationPhylogenomic databases
GeneTreei | ENSGT01030000234601 |
HOGENOMi | CLU_059744_4_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR000768, ART |
Pfami | View protein in Pfam PF01129, ART, 1 hit |
PRINTSi | PR00970, RIBTRNSFRASE |
PROSITEi | View protein in PROSITE PS01291, ART, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
H7C2G2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
PPATMRIWLL GGLLPFLLLL SGLQRPTEGS EVAIKIDFDF APGSFDDQYQ
60 70 80 90 100
GCSKQVMEKL TQGDYFTKDI EAQKNYFRMW QKAHLAWLNQ GKVLPQNMTT
110 120 130 140 150
THAVAILFYT LNSNVHSDFT RAMASVARTP QQYERSFHFK YLHYYLTSAI
160 170 180 190 200
QLLRKDSIME NGTLCYEVHY RTKDVHFNAY TGATIRFGQF LSTSLLKEEA
210 220 230 240 250
QEFGNQTLFT IFTCLGAPVQ YFSLKKEVLI PPYELFKVIN MSYHPRGDWL
260 270
QLRSTGNLST YNCQLLKGIL YLN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ93070 | NAR4_HUMAN | Ecto-ADP-ribosyltransferase 4 | ART4 DO, DOK1 | 314 | Annotation score: | ||
Q3KZ30 | Q3KZ30_HUMAN | Dombrock blood group carrier molecu... | ART4 DO | 65 | Annotation score: | ||
Q3KZ29 | Q3KZ29_HUMAN | Dombrock blood group carrier molecu... | ART4 DO | 41 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007655 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000420600; ENSP00000405689; ENSG00000111339 |
UCSCi | uc058lnd.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007655 Genomic DNA No translation available. |
3D structure databases
SMRi | H7C2G2 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | H7C2G2 |
PRIDEi | H7C2G2 |
ProteomicsDBi | 44977 |
Protocols and materials databases
Antibodypediai | 23686, 160 antibodies from 22 providers |
Genome annotation databases
Ensembli | ENST00000420600; ENSP00000405689; ENSG00000111339 |
UCSCi | uc058lnd.1, human |
Organism-specific databases
HGNCi | HGNC:726, ART4 |
OpenTargetsi | ENSG00000111339 |
VEuPathDBi | HostDB:ENSG00000111339 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01030000234601 |
HOGENOMi | CLU_059744_4_0_1 |
Miscellaneous databases
ChiTaRSi | ART4, human |
Gene expression databases
Bgeei | ENSG00000111339, Expressed in amniotic fluid and 112 other tissues |
ExpressionAtlasi | H7C2G2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000768, ART |
Pfami | View protein in Pfam PF01129, ART, 1 hit |
PRINTSi | PR00970, RIBTRNSFRASE |
PROSITEi | View protein in PROSITE PS01291, ART, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H7C2G2_HUMAN | |
Accessioni | H7C2G2Primary (citable) accession number: H7C2G2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | January 19, 2022 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |