UniProtKB - H7C269 (H7C269_HUMAN)
Protein
Submitted name:
Trinucleotide repeat-containing gene 6A protein
Gene
TNRC6A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- nucleic acid binding Source: InterPro
GO - Biological processi
- miRNA mediated inhibition of translation Source: InterPro
Keywordsi
Biological process | RNA-mediated gene silencingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Trinucleotide repeat-containing gene 6A proteinImported |
Gene namesi | Name:TNRC6AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000090905.17 |
HGNCi | HGNC:11969, TNRC6A |
Subcellular locationi
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
PTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
MaxQBi | H7C269 |
PeptideAtlasi | H7C269 |
PRIDEi | H7C269 |
ProteomicsDBi | 44886 |
Expressioni
Gene expression databases
Bgeei | ENSG00000090905, Expressed in cerebellar vermis and 215 other tissues |
ExpressionAtlasi | H7C269, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 194 | Ago_hookInterPro annotationAdd BLAST | 147 | |
Domaini | 449 – 722 | TNRC6-PABC_bdgInterPro annotationAdd BLAST | 274 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 128 | DisorderedSequence analysisAdd BLAST | 128 | |
Regioni | 156 – 187 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 242 – 266 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 282 – 314 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 368 – 400 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 521 – 579 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 668 – 696 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 34 – 56 | PolyampholyteSequence analysisAdd BLAST | 23 | |
Compositional biasi | 63 – 114 | PolarSequence analysisAdd BLAST | 52 | |
Compositional biasi | 282 – 309 | PolarSequence analysisAdd BLAST | 28 | |
Compositional biasi | 670 – 684 | Pro-richSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the GW182 family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000158180 |
HOGENOMi | CLU_001298_2_0_1 |
Family and domain databases
CDDi | cd12711, RRM_TNRC6A, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR019486, Argonaute_hook_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR032226, TNRC6_PABC-bd IPR033501, TNRC6A IPR034924, TNRC6A_RRM |
PANTHERi | PTHR13020:SF28, PTHR13020:SF28, 3 hits |
Pfami | View protein in Pfam PF10427, Ago_hook, 1 hit PF16608, TNRC6-PABC_bdg, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
H7C269-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
QQDIVGSWGI PPATGKPPGT GWLGGPIPAP AKEEEPTGWE EPSPESIRRK
60 70 80 90 100
MEIDDGTSAW GDPSKYNYKN VNMWNKNVPN GNSRSDQQAQ VHQLLTPASA
110 120 130 140 150
ISNKEASSGS GPKSMQDGWC GDDMPLPGNR PTGWEEEEDV EIGMWNSNSS
160 170 180 190 200
QELNSSLNWP PYTKKMSSKG LSGKKRRRER GMMKGGNKQE EAWINPFVKQ
210 220 230 240 250
FSNISFSRDS PEENVQSNKM DLSGGMLQDK RMEIDKHSLN IGDYNRTVGK
260 270 280 290 300
GPGSRPQISK ESSMERNPYF DKNGNPSMFG VGNTAAQPRG MQQPPAQPLS
310 320 330 340 350
SSQPNLRAQV PPPLLSPQVP VSLLKYAPNN GGLNPLFGPQ QVAMLNQLSQ
360 370 380 390 400
LNQLSQISQL QRLLAQQQRA QSQRSVPSGN RPQQDQQGRP LSVQQQMMQQ
410 420 430 440 450
SRQLDPNLLV KQQTPPSQQQ PLHQPAMKSF LDNVMPHTTP ELQKGPSPIN
460 470 480 490 500
AFSNFPIGLN SNLNVNMDMN SIKEPQSRLR KWTTVDSISV NTSLDQNSSK
510 520 530 540 550
HGAISSGFRL EESPFVPYDF MNSSTSPASP PGSIGDGWPR AKSPNGSSSV
560 570 580 590 600
NWPPEFRPGE PWKGYPNIDP ETDPYVTPGS VINNLSINTV REVDHLRDRN
610 620 630 640 650
SGSSSSLNTT LPSTSAWSSI RASNYNVPLS STAQSTSARN SDSKLTWSPG
660 670 680 690 700
SVTNTSLAHE LWKVPLPPKN ITAPSRPPPG LTGQKPPLST WDNSPLRIGG
710 720 730 740 750
GWGNSDARYT PGSSWGESSS GRITNWLVLK NLTPQIDGST LRTLCMQHGP
760 770 780 790 800
LITFHLNLPH GNALVRYSSK EEVVKAQKSL HMCVLGNTTI LAEFASEEEI
810 820 830 840 850
SRFFAQSQSL TPSPGWQSLG SSQSRLGSLD CSHSFSSRTD LNHWNGAGLS
860 870 880 890 900
GTNCGDLHGT SLWGTPHYST SLWGPPSSSD PRGISSPSPI NAFLSVDHLG
GGGESM
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8NDV7 | TNR6A_HUMAN | Trinucleotide repeat-containing gen... | TNRC6A CAGH26, KIAA1460, TNRC6 | 1,962 | Annotation score: | ||
H3BRT3 | H3BRT3_HUMAN | Trinucleotide repeat-containing gen... | TNRC6A | 160 | Annotation score: | ||
H3BTQ1 | H3BTQ1_HUMAN | Trinucleotide repeat-containing gen... | TNRC6A | 203 | Annotation score: | ||
I3L218 | I3L218_HUMAN | Trinucleotide repeat-containing gen... | TNRC6A | 96 | Annotation score: | ||
I3L3S5 | I3L3S5_HUMAN | Trinucleotide repeat-containing gen... | TNRC6A | 40 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC002565 Genomic DNA No translation available. AC008731 Genomic DNA No translation available. AC010321 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000450465; ENSP00000404278; ENSG00000090905 |
UCSCi | uc059sfl.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC002565 Genomic DNA No translation available. AC008731 Genomic DNA No translation available. AC010321 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | H7C269 |
PeptideAtlasi | H7C269 |
PRIDEi | H7C269 |
ProteomicsDBi | 44886 |
Protocols and materials databases
Antibodypediai | 12719, 107 antibodies |
Genome annotation databases
Ensembli | ENST00000450465; ENSP00000404278; ENSG00000090905 |
UCSCi | uc059sfl.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000090905.17 |
HGNCi | HGNC:11969, TNRC6A |
OpenTargetsi | ENSG00000090905 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158180 |
HOGENOMi | CLU_001298_2_0_1 |
Miscellaneous databases
ChiTaRSi | TNRC6A, human |
Gene expression databases
Bgeei | ENSG00000090905, Expressed in cerebellar vermis and 215 other tissues |
ExpressionAtlasi | H7C269, baseline and differential |
Family and domain databases
CDDi | cd12711, RRM_TNRC6A, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR019486, Argonaute_hook_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR032226, TNRC6_PABC-bd IPR033501, TNRC6A IPR034924, TNRC6A_RRM |
PANTHERi | PTHR13020:SF28, PTHR13020:SF28, 3 hits |
Pfami | View protein in Pfam PF10427, Ago_hook, 1 hit PF16608, TNRC6-PABC_bdg, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H7C269_HUMAN | |
Accessioni | H7C269Primary (citable) accession number: H7C269 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | December 2, 2020 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |