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Protein
Submitted name:

Presenilins-associated rhomboid-like protein, mitochondrial

Gene

PARL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Presenilins-associated rhomboid-like protein, mitochondrialImported
Gene namesi
Name:PARLImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000175193.12
HGNCiHGNC:18253 PARL

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175193

Expressioni

Gene expression databases

BgeeiENSG00000175193 Expressed in 227 organ(s), highest expression level in oocyte
ExpressionAtlasiH7C1V6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7C1V6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 56RhomboidInterPro annotationAdd BLAST56

Phylogenomic databases

eggNOGiKOG2980 Eukaryota
COG0705 LUCA
GeneTreeiENSGT00390000013063

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

H7C1V6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
HMAANMYVLW SFSSSIVNIL GQEQFMAVYL SAGVISNFVS YVGKVATGRY
60
GPSLGAMVCY LRS
Length:63
Mass (Da):6,844
Last modified:April 18, 2012 - v1
Checksum:iA15DC8AB669C95EA
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9H300PARL_HUMAN
Presenilins-associated rhomboid-lik...
PARL PSARL, PRO2207
379Annotation score:
H7C122H7C122_HUMAN
Presenilins-associated rhomboid-lik...
PARL
171Annotation score:
A0A1W2PP66A0A1W2PP66_HUMAN
Presenilins-associated rhomboid-lik...
PARL
188Annotation score:
C9JNP8C9JNP8_HUMAN
Presenilins-associated rhomboid-lik...
PARL
295Annotation score:
H7C045H7C045_HUMAN
Presenilins-associated rhomboid-lik...
PARL
112Annotation score:
H7C0U0H7C0U0_HUMAN
Presenilins-associated rhomboid-lik...
PARL
159Annotation score:
F8WCQ4F8WCQ4_HUMAN
Presenilins-associated rhomboid-lik...
PARL
173Annotation score:
A0A1W2PS40A0A1W2PS40_HUMAN
Presenilins-associated rhomboid-lik...
PARL
177Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068644 Genomic DNA No translation available.
AC131160 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000450375; ENSP00000402689; ENSG00000175193
UCSCiuc062qpx.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068644 Genomic DNA No translation available.
AC131160 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH7C1V6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000450375; ENSP00000402689; ENSG00000175193
UCSCiuc062qpx.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000175193.12
HGNCiHGNC:18253 PARL
OpenTargetsiENSG00000175193
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2980 Eukaryota
COG0705 LUCA
GeneTreeiENSGT00390000013063

Miscellaneous databases

ChiTaRSiPARL human

Gene expression databases

BgeeiENSG00000175193 Expressed in 227 organ(s), highest expression level in oocyte
ExpressionAtlasiH7C1V6 baseline and differential

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH7C1V6_HUMAN
AccessioniPrimary (citable) accession number: H7C1V6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 12, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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