UniProtKB - H7C1S2 (H7C1S2_HUMAN)
Protein
Submitted name:
Bifunctional purine biosynthesis protein ATIC
Gene
ATIC
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- IMP cyclohydrolase activity Source: InterPro
- phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: InterPro
GO - Biological processi
- purine nucleotide biosynthetic process Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Bifunctional purine biosynthesis protein ATICImported |
Gene namesi | Name:ATICImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:794, ATIC |
VEuPathDBi | HostDB:ENSG00000138363.14 |
PTM / Processingi
Proteomic databases
MaxQBi | H7C1S2 |
PeptideAtlasi | H7C1S2 |
PRIDEi | H7C1S2 |
ProteomicsDBi | 44740 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138363, Expressed in adrenal gland and 241 other tissues |
ExpressionAtlasi | H7C1S2, baseline and differential |
Family & Domainsi
Phylogenomic databases
GeneTreei | ENSGT00390000004553 |
HOGENOMi | CLU_1083934_0_0_1 |
Family and domain databases
Gene3Di | 1.10.287.440, 1 hit 3.40.140.20, 2 hits |
InterProi | View protein in InterPro IPR024051, AICAR_Tfase_dup_dom_sf IPR024050, AICAR_Tfase_insert_dom_sf IPR016193, Cytidine_deaminase-like IPR002695, PurH-like |
PANTHERi | PTHR11692, PTHR11692, 1 hit |
Pfami | View protein in Pfam PF01808, AICARFT_IMPCHas, 1 hit |
SMARTi | View protein in SMART SM00798, AICARFT_IMPCHas, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
H7C1S2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XIFLQVSDGI IAPGYEEEAL TILSKKKNGN YCVLQMDQSY KPDENEVRTL
60 70 80 90 100
FGLHLSQKRN NGVVDKSLFS NVVTKNKDLP ESALRDLIVA TIAVKYTQSN
110 120 130 140 150
SVCYAKNGQV IGIGAGQQSR IHCTRLAGDK ANYWWLRHHP QVLSMKFKTG
160 170 180 190 200
VKRAEISNAI DQYVTGTIGE DEDLIKWKAL FEEVPELLTE AEKKEWVEKL
210 220 230
TEVSISSDAF FPFRDNVDRA KRVSMELGAF A
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP31939 | PUR9_HUMAN | Bifunctional purine biosynthesis pr... | ATIC PURH, OK/SW-cl.86 | 592 | Annotation score: | ||
C9JLK0 | C9JLK0_HUMAN | AICAR transformylase/inosine monoph... | ATIC | 170 | Annotation score: | ||
F8WEF0 | F8WEF0_HUMAN | AICAR transformylase/inosine monoph... | ATIC | 84 | Annotation score: | ||
F2Z3E8 | F2Z3E8_HUMAN | Bifunctional purine biosynthesis pr... | ATIC | 43 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073284 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000426233; ENSP00000401936; ENSG00000138363 |
UCSCi | uc061scl.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073284 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | H7C1S2 |
PeptideAtlasi | H7C1S2 |
PRIDEi | H7C1S2 |
ProteomicsDBi | 44740 |
Protocols and materials databases
Antibodypediai | 4601, 391 antibodies |
Genome annotation databases
Ensembli | ENST00000426233; ENSP00000401936; ENSG00000138363 |
UCSCi | uc061scl.1, human |
Organism-specific databases
HGNCi | HGNC:794, ATIC |
OpenTargetsi | ENSG00000138363 |
VEuPathDBi | HostDB:ENSG00000138363.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000004553 |
HOGENOMi | CLU_1083934_0_0_1 |
Miscellaneous databases
ChiTaRSi | ATIC, human |
Gene expression databases
Bgeei | ENSG00000138363, Expressed in adrenal gland and 241 other tissues |
ExpressionAtlasi | H7C1S2, baseline and differential |
Family and domain databases
Gene3Di | 1.10.287.440, 1 hit 3.40.140.20, 2 hits |
InterProi | View protein in InterPro IPR024051, AICAR_Tfase_dup_dom_sf IPR024050, AICAR_Tfase_insert_dom_sf IPR016193, Cytidine_deaminase-like IPR002695, PurH-like |
PANTHERi | PTHR11692, PTHR11692, 1 hit |
Pfami | View protein in Pfam PF01808, AICARFT_IMPCHas, 1 hit |
SMARTi | View protein in SMART SM00798, AICARFT_IMPCHas, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H7C1S2_HUMAN | |
Accessioni | H7C1S2Primary (citable) accession number: H7C1S2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | February 10, 2021 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |