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Entry version 53 (11 Dec 2019)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Protein cordon-bleu

Gene

COBL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein cordon-bleuImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COBLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000106078.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22199 COBL

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000106078

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
H7C1N2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H7C1N2

PeptideAtlas

More...
PeptideAtlasi
H7C1N2

PRoteomics IDEntifications database

More...
PRIDEi
H7C1N2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
44701

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106078 Expressed in 195 organ(s), highest expression level in globus pallidus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H7C1N2 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1001 – 1021WH2InterPro annotationAdd BLAST21
Domaini1041 – 1061WH2InterPro annotationAdd BLAST21
Domaini1082 – 1102WH2InterPro annotationAdd BLAST21

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni129 – 372DisorderedSequence analysisAdd BLAST244
Regioni392 – 426DisorderedSequence analysisAdd BLAST35
Regioni472 – 492DisorderedSequence analysisAdd BLAST21
Regioni550 – 591DisorderedSequence analysisAdd BLAST42
Regioni671 – 735DisorderedSequence analysisAdd BLAST65
Regioni801 – 860DisorderedSequence analysisAdd BLAST60
Regioni881 – 952DisorderedSequence analysisAdd BLAST72
Regioni1013 – 1033DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi154 – 183PolarSequence analysisAdd BLAST30
Compositional biasi227 – 243Pro-richSequence analysisAdd BLAST17
Compositional biasi288 – 315PolarSequence analysisAdd BLAST28
Compositional biasi316 – 330PolyampholyteSequence analysisAdd BLAST15
Compositional biasi350 – 364PolarSequence analysisAdd BLAST15
Compositional biasi401 – 415PolarSequence analysisAdd BLAST15
Compositional biasi553 – 586PolarSequence analysisAdd BLAST34
Compositional biasi679 – 707PolarSequence analysisAdd BLAST29
Compositional biasi881 – 902PolarSequence analysisAdd BLAST22
Compositional biasi1013 – 1027PolyampholyteSequence analysisAdd BLAST15

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063608

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039895 COBL-like
IPR019025 Cordon-bleu_ubiquitin_domain
IPR003124 WH2_dom

The PANTHER Classification System

More...
PANTHERi
PTHR47008 PTHR47008, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09469 Cobl, 1 hit
PF02205 WH2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00246 WH2, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51082 WH2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

H7C1N2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LKEKVPEEKV KPGPPKVPEK SVRLVVNYLR TQKAVVRVSP EVPLQNILPV
60 70 80 90 100
ICAKCEVSPE HVVLLRDNIA GEELELSKSL NELGIKELYA WDNRRETFRK
110 120 130 140 150
SSLGNDETDK EKKKFLGFFK VNKRSNSKAE QLVLSGADSD EDTSRAAPGR
160 170 180 190 200
GLNGCLTTPN SPSMHSRSLT LGPSLSLGSI SGVSVKSEMK KRRAPPPPGS
210 220 230 240 250
GPPVQDKASE KVSLGSQIDL QKKKRRAPAP PPPQPPPPSP LIPNRTEDKE
260 270 280 290 300
ENRKSTMVSL PLGSGSHCSP DGAPQVLSEA EETVSVGSCF ASEDTTEDSG
310 320 330 340 350
VMSSPSDIVS LDSQQDSMKY KDKWATDQED CSDQDLAGTP DLGPQKSPLW
360 370 380 390 400
EKNGSENSHL RTEKAVTASN DEEDLLIAGE FRKTLAELDE DLEEMEDSYE
410 420 430 440 450
TDTSSLTSSI HGASNHCPQD AMIPHGDTDA IPVTFIGEVS DDPVDSGLFS
460 470 480 490 500
NRNNNAGSFD SEGVASRRDS LAPLQAEHSQ PHEKAREEVP ALHPASHDVG
510 520 530 540 550
KGIRVALSNI SKDGNLMETA PRVTSFASNL HTDNLNAKVK DKVYGCADGE
560 570 580 590 600
RTQATERVNS QPVNEKDSND KNAALAPTSW HQRGQNPGKS YRLKHGLTTY
610 620 630 640 650
KIIPPKSEMR CYDRDVSLST GAIKIDELGN LVSPHATGIR IISLSSSVPE
660 670 680 690 700
AESQPIGKVR EFWRCNSVEK HLGRPSESSA RGPPSTPVPT QTQNPESRLQ
710 720 730 740 750
ADPKPISPQQ KSAHHEGRNP LGEGRNQPPT MGMGHVRVPA AHTTEVTFLK
760 770 780 790 800
PQRRTSSQYV ASAIAKRIGA PKVHADVVRP HGYAEKGYAG KAPVLAAPPV
810 820 830 840 850
TVKDDRTSSP HSETQGWKDG AQWPCVTPPN NHGEDLAVGA PPRGEVIGPH
860 870 880 890 900
RKLSTQDRPA AIHRSSCFSL VQSSQRDRVS VGQSCGFSGK QSTSSQEASS
910 920 930 940 950
ASEPRRAPDG TDPPPPHTSD TQACSRELVN GSVRAPGHGE PSHPPGGSGT
960 970 980 990 1000
ESHILLEREE KPSVFSTDGN ETDSIWPPSI FGPKKKFKPV VQRPVPKDTS
1010 1020 1030 1040 1050
LHSALMEAIH SAGGKDRLRK TAEHTGEGRP AKLSYTEAEG ERSALLAAIR
1060 1070 1080 1090 1100
GHSGTCSLRK ALSAPRTASR FSTGTLSNTA DARQALMDAI RSGTGAARLR

KVPLLV
Length:1,106
Mass (Da):119,038
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9557E329FF9C2508
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O75128COBL_HUMAN
Protein cordon-bleu
COBL KIAA0633
1,261Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KR05J3KR05_HUMAN
Protein cordon-bleu
COBL
1,146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWK3A0A0J9YWK3_HUMAN
Protein cordon-bleu
COBL
394Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU00A0A3B3IU00_HUMAN
Protein cordon-bleu
COBL
406Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9X1C9J9X1_HUMAN
Protein cordon-bleu
COBL
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004414 Genomic DNA No translation available.
AC005535 Genomic DNA No translation available.
AC012372 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000445054; ENSP00000401204; ENSG00000106078

UCSC genome browser

More...
UCSCi
uc064drf.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004414 Genomic DNA No translation available.
AC005535 Genomic DNA No translation available.
AC012372 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

jPOSTiH7C1N2
MaxQBiH7C1N2
PeptideAtlasiH7C1N2
PRIDEiH7C1N2
ProteomicsDBi44701

Genome annotation databases

EnsembliENST00000445054; ENSP00000401204; ENSG00000106078
UCSCiuc064drf.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000106078.17
HGNCiHGNC:22199 COBL
OpenTargetsiENSG00000106078

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00530000063608

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COBL human

Gene expression databases

BgeeiENSG00000106078 Expressed in 195 organ(s), highest expression level in globus pallidus
ExpressionAtlasiH7C1N2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR039895 COBL-like
IPR019025 Cordon-bleu_ubiquitin_domain
IPR003124 WH2_dom
PANTHERiPTHR47008 PTHR47008, 3 hits
PfamiView protein in Pfam
PF09469 Cobl, 1 hit
PF02205 WH2, 3 hits
SMARTiView protein in SMART
SM00246 WH2, 3 hits
PROSITEiView protein in PROSITE
PS51082 WH2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH7C1N2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H7C1N2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: December 11, 2019
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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