UniProtKB - H7C0B6 (H7C0B6_HUMAN)
Protein
Submitted name:
Villin-1
Gene
VIL1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin filament binding Source: InterPro
- calcium ion binding Source: InterPro
- phosphatidylinositol-4,5-bisphosphate binding Source: InterPro
GO - Biological processi
- actin filament capping Source: InterPro
- actin filament severing Source: InterPro
- actin nucleation Source: InterPro
Keywordsi
Molecular function | Actin-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Villin-1Imported |
Gene namesi | Name:VIL1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000127831.10 |
HGNCi | HGNC:12690, VIL1 |
PTM / Processingi
Proteomic databases
MaxQBi | H7C0B6 |
PeptideAtlasi | H7C0B6 |
PRIDEi | H7C0B6 |
ProteomicsDBi | 44242 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127831, Expressed in small intestine and 121 other tissues |
ExpressionAtlasi | H7C0B6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 58 | Gelsolin-likeInterPro annotationAdd BLAST | 43 | |
Domaini | 98 – 164 | Gelsolin-likeInterPro annotationAdd BLAST | 67 |
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160544 |
HOGENOMi | CLU_1297006_0_0_1 |
Family and domain databases
Gene3Di | 3.40.20.10, 3 hits |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR007123, Gelsolin-like_dom IPR030007, Villin IPR007122, Villin/Gelsolin |
PANTHERi | PTHR11977, PTHR11977, 1 hit PTHR11977:SF35, PTHR11977:SF35, 1 hit |
Pfami | View protein in Pfam PF00626, Gelsolin, 2 hits |
PRINTSi | PR00597, GELSOLIN |
SMARTi | View protein in SMART SM00262, GEL, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
H7C0B6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GAERKGGGLG LRLGLQGSQA SQDEITASAY QAVILDQKYN GEPVQIRVPM
60 70 80 90 100
GKEPPHLMSI FKGRMVVYQG GTSRTNNLET GPSTRLFQVQ GTGANNTKAF
110 120 130 140 150
EVPARANFLN SNDVFVLKTQ SCCYLWCGKG CSGDEREMAK MVADTISRTE
160 170 180 190 200
KQVVVEGQEP ANFWMALGGK APYANTKRLQ EENLVITPRL FECSNKTGRF
210
LATEIPDFNQ DDL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP09327 | VILI_HUMAN | Villin-1 | VIL1 VIL | 827 | Annotation score: | ||
B4DV78 | B4DV78_HUMAN | Villin-1 | VIL1 | 516 | Annotation score: | ||
C9J2B5 | C9J2B5_HUMAN | Villin-1 | VIL1 | 157 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 213 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021016 Genomic DNA No translation available. AC073838 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000419986; ENSP00000394030; ENSG00000127831 |
UCSCi | uc061slq.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021016 Genomic DNA No translation available. AC073838 Genomic DNA No translation available. |
3D structure databases
SMRi | H7C0B6 |
ModBasei | Search... |
Proteomic databases
MaxQBi | H7C0B6 |
PeptideAtlasi | H7C0B6 |
PRIDEi | H7C0B6 |
ProteomicsDBi | 44242 |
Protocols and materials databases
Antibodypediai | 1531, 652 antibodies |
Genome annotation databases
Ensembli | ENST00000419986; ENSP00000394030; ENSG00000127831 |
UCSCi | uc061slq.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000127831.10 |
HGNCi | HGNC:12690, VIL1 |
OpenTargetsi | ENSG00000127831 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160544 |
HOGENOMi | CLU_1297006_0_0_1 |
Miscellaneous databases
ChiTaRSi | VIL1, human |
Gene expression databases
Bgeei | ENSG00000127831, Expressed in small intestine and 121 other tissues |
ExpressionAtlasi | H7C0B6, baseline and differential |
Family and domain databases
Gene3Di | 3.40.20.10, 3 hits |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR007123, Gelsolin-like_dom IPR030007, Villin IPR007122, Villin/Gelsolin |
PANTHERi | PTHR11977, PTHR11977, 1 hit PTHR11977:SF35, PTHR11977:SF35, 1 hit |
Pfami | View protein in Pfam PF00626, Gelsolin, 2 hits |
PRINTSi | PR00597, GELSOLIN |
SMARTi | View protein in SMART SM00262, GEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H7C0B6_HUMAN | |
Accessioni | H7C0B6Primary (citable) accession number: H7C0B6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | August 12, 2020 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |