UniProtKB - H7BZT3 (H7BZT3_HUMAN)
Protein
Histone deacetylase
Gene
HDAC4
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.5.1.98ARBA annotation
GO - Molecular functioni
- NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
Keywordsi
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HDAC4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14063, HDAC4 |
VEuPathDBi | HostDB:ENSG00000068024.16 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- histone deacetylase complex Source: InterPro
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000068024, Expressed in sural nerve and 228 other tissues |
ExpressionAtlasi | H7BZT3, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 34 – 67 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 86 – 117 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 34 – 57 | PolarSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000157440 |
HOGENOMi | CLU_1772326_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR033660, HDAC4/7 IPR017320, Histone_deAcase_II_euk |
PANTHERi | PTHR45364, PTHR45364, 1 hit PTHR45364:SF3, PTHR45364:SF3, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
H7BZT3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XWLYLFPHPP HPPHCGSGLY LQSHHLQQAW IPHSACSSAP GSGPSSPNNS
60 70 80 90 100
SGSVSAENGI APAVPSIPAE TSLAHRLVAR EGSAAPLPLY TSPSLPNITL
110 120 130 140
GLPATGPSAG TAGQQDAERL TLPALQQRLS LFPGTHLTPY LSTSPLER
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP56524 | HDAC4_HUMAN | Histone deacetylase 4 | HDAC4 KIAA0288 | 1,084 | Annotation score: | ||
C9J481 | C9J481_HUMAN | Histone deacetylase | HDAC4 | 162 | Annotation score: | ||
C9J0X4 | C9J0X4_HUMAN | Histone deacetylase | HDAC4 | 123 | Annotation score: | ||
H7C397 | H7C397_HUMAN | Histone deacetylase 4 | HDAC4 | 175 | Annotation score: | ||
A0A7I2SVS4 | A0A7I2SVS4_HUMAN | Histone deacetylase 4 | HDAC4 | 1,089 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 148 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC017028 Genomic DNA No translation available. AC062017 Genomic DNA No translation available. KF510800 Genomic DNA No translation available. KF510801 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000445704; ENSP00000391226; ENSG00000068024 |
UCSCi | uc061ufy.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC017028 Genomic DNA No translation available. AC062017 Genomic DNA No translation available. KF510800 Genomic DNA No translation available. KF510801 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | H7BZT3 |
PeptideAtlasi | H7BZT3 |
ProteomicsDBi | 44062 |
Protocols and materials databases
Antibodypediai | 3835, 1185 antibodies |
Genome annotation databases
Ensembli | ENST00000445704; ENSP00000391226; ENSG00000068024 |
UCSCi | uc061ufy.1, human |
Organism-specific databases
HGNCi | HGNC:14063, HDAC4 |
OpenTargetsi | ENSG00000068024 |
VEuPathDBi | HostDB:ENSG00000068024.16 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157440 |
HOGENOMi | CLU_1772326_0_0_1 |
Miscellaneous databases
ChiTaRSi | HDAC4, human |
Gene expression databases
Bgeei | ENSG00000068024, Expressed in sural nerve and 228 other tissues |
ExpressionAtlasi | H7BZT3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR033660, HDAC4/7 IPR017320, Histone_deAcase_II_euk |
PANTHERi | PTHR45364, PTHR45364, 1 hit PTHR45364:SF3, PTHR45364:SF3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H7BZT3_HUMAN | |
Accessioni | H7BZT3Primary (citable) accession number: H7BZT3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | April 7, 2021 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |