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Entry version 60 (02 Jun 2021)
Sequence version 4 (13 Nov 2019)
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Protein

Ciliary rootlet coiled-coil protein 2

Gene

CROCC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
H7BZ55

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ciliary rootlet coiled-coil protein 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CROCC2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:51677, CROCC2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_H7BZ55

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000226321.5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
H7BZ55, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CROCC2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004226131 – 1653Ciliary rootlet coiled-coil protein 2Add BLAST1653

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
H7BZ55

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
H7BZ55

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
H7BZ55

PeptideAtlas

More...
PeptideAtlasi
H7BZ55

PRoteomics IDEntifications database

More...
PRIDEi
H7BZ55

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
43840

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
H7BZ55

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000226321, Expressed in right uterine tube and 78 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000226321, Tissue enhanced (brain, epididymis, fallopian tube)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
H7BZ55, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000397968

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
H7BZ55, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
H7BZ55

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 57DisorderedSequence analysisAdd BLAST57
Regioni367 – 396DisorderedSequence analysisAdd BLAST30
Regioni1302 – 1356DisorderedSequence analysisAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili86 – 145Sequence analysisAdd BLAST60
Coiled coili310 – 351Sequence analysisAdd BLAST42
Coiled coili423 – 1215Sequence analysisAdd BLAST793
Coiled coili1361 – 1570Sequence analysisAdd BLAST210

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 21Polar residuesSequence analysisAdd BLAST21
Compositional biasi1307 – 1338Polar residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rootletin family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQV3, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000920_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H7BZ55

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H7BZ55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSASSEPGN GDASQQPLLG LDTVIQRLED TILSPTASRE DRALTVRGEG
60 70 80 90 100
RQASPTPVPT RIREIVAGSL SEEPPQAGVQ EPTATVARVQ EENELLQEEL
110 120 130 140 150
TRLGDLLAQA SAERDELASR CRVVSEQLQA RLETTEAQLR RSELEHSVDL
160 170 180 190 200
EEALGRLEAA EERSTGLCQV NALLREQLEH MKKANDALGR ELAGMTGSVQ
210 220 230 240 250
RLQGELELRR WAQRQTRSGG LGQPRDLLLL WRQAVVLGTD LAELRVATER
260 270 280 290 300
GLADLQADTA RTARRLHTAC LNLDSNLRLS ASSTASTLGQ QLRDKAGEML
310 320 330 340 350
QLQGRWDAEK VALQARLSEQ TLLVEKLTEQ NEQKAKTIAA LRTDLQNLVA
360 370 380 390 400
QEDARCLELA GSSITELGEP RRPLRSPQRA TSPHQGASPP HICSPATLDP
410 420 430 440 450
ALQAMRAAIE RRWRREQELC LQLKSSQALV ASLQEQLSES RRELWAAQKL
460 470 480 490 500
QQERAREQAR EREALRGQLE AQRLEVQQCR ASCKLLGREK AALEMVVEEL
510 520 530 540 550
KGKADAADAE KQGLEAEAAE LQRSLLLQAE RREELALRRE RSCRALETSQ
560 570 580 590 600
GRLQQLEEKV SGLREELASV REALSTAQLQ RDVVESEREG LRSALARAEC
610 620 630 640 650
SNADLELLVR RLKSEGVEQR DSLAAMAALM EGLAQDKSAL NHLALQLEQE
660 670 680 690 700
RDQLREQRKT LEQERARAGE QLAQAEQQLA LERAERRGLQ QACGRLEQRQ
710 720 730 740 750
EQLEGQAALL GREKAQLQEQ VGQVTCQKQA LEEQLAQSLQ DQEAQMGTLQ
760 770 780 790 800
QALQGKDALS EERAQLLAKQ EALERQGRLA AEEAADLRVE RDSLESSLLE
810 820 830 840 850
AQQLATKLQE QLEEEARSAG LARQALQVEM EQLQSDWEVQ EMKLRQDTVR
860 870 880 890 900
LQRQVAQQER EAQRALESQA LAHREALAQL QREKETLSLT LAEEKEVARC
910 920 930 940 950
QLEQEKELVT KSAAEREALK GEIQSLKQER DESLLQLEHK MQQALSLKET
960 970 980 990 1000
ERSLLSEELS RARRTLERVQ QEAQSQQEQA QATISATTEE LKALQAQFED
1010 1020 1030 1040 1050
AITAHQRETT ALRESLQDLA AERGDVEREA ERLRAQLTVA QEGLAALRQE
1060 1070 1080 1090 1100
LQGVEESREG LHREAQEARR ALSDEAREKD VLLLFNSELR ATICRAEQEK
1110 1120 1130 1140 1150
ASFKRSKEEK EQKLLILEEA QAALQQEASA LRAHLWELEQ AGGDARQELR
1160 1170 1180 1190 1200
ELHRQVRTLK AENQRRSGEA HELQAQCSQE VLELRRQAAK AEAKHEGARK
1210 1220 1230 1240 1250
EVLGLQRKLA EVEAAGEAHG QRLQEHLRES RGAEQTLRAE LHSVTRKLQE
1260 1270 1280 1290 1300
ASGVADALQA RLDQACHRIH SLEQELAQAE GARQDAEAQL GRLCSTLRRG
1310 1320 1330 1340 1350
LGLQRQSPWA SPEQPGSPTK GSDSSQALPG QQGTSPPARP HSPLRWPSPT
1360 1370 1380 1390 1400
PGGRSSELMD VATVQDILRD FVQKLREAQR ERDDSRIQMA TLSSRLSEAE
1410 1420 1430 1440 1450
CRCARAQSRV GQLQKALAEA EEGQRRVEGA LSSARAARAL QKEALRRLEL
1460 1470 1480 1490 1500
EHLASVRAAG QEKRRLQEQL ETLRQALEES RRHSQGLAKQ GKLLEEQLTN
1510 1520 1530 1540 1550
LEHRCQKAEV SLEPLRQMEQ ETLKREEDVA RLGAEKEQLD QSLNSLHQEV
1560 1570 1580 1590 1600
DGALRQNQQL QAQMTEMEQA HTQRLQDLTA QHQRDLATEA ERLHGARPQA
1610 1620 1630 1640 1650
TQALESQEWT HQQQVKVLEE QVASLKEQLD QEVQWRQQAH LGQAFQTGHA

QRD
Length:1,653
Mass (Da):185,641
Last modified:November 13, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE6A4A0296654CD7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC104809 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000443866; ENSP00000397968; ENSG00000226321

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104809 Genomic DNA No translation available.

3D structure databases

SMRiH7BZ55
ModBaseiSearch...

Protein-protein interaction databases

IntActiH7BZ55, 2 interactors
STRINGi9606.ENSP00000397968

PTM databases

PhosphoSitePlusiH7BZ55

Genetic variation databases

BioMutaiCROCC2

Proteomic databases

jPOSTiH7BZ55
MassIVEiH7BZ55
PaxDbiH7BZ55
PeptideAtlasiH7BZ55
PRIDEiH7BZ55
ProteomicsDBi43840

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
62332, 3 antibodies

Genome annotation databases

EnsembliENST00000443866; ENSP00000397968; ENSG00000226321

Organism-specific databases

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CROCC2
HGNCiHGNC:51677, CROCC2
HPAiENSG00000226321, Tissue enhanced (brain, epididymis, fallopian tube)
neXtProtiNX_H7BZ55
VEuPathDBiHostDB:ENSG00000226321.5

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QQV3, Eukaryota
HOGENOMiCLU_000920_1_0_1
InParanoidiH7BZ55

Enzyme and pathway databases

PathwayCommonsiH7BZ55

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CROCC2, human
PharosiH7BZ55, Tdark
RNActiH7BZ55, protein

Gene expression databases

BgeeiENSG00000226321, Expressed in right uterine tube and 78 other tissues

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRCC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H7BZ55
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: November 13, 2019
Last modified: June 2, 2021
This is version 60 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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