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Entry version 51 (08 May 2019)
Sequence version 3 (01 Apr 2015)
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Protein

Putative ciliary rootlet coiled-coil protein 2

Gene

CROCC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein uncertaini <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Could be the product of a pseudogene.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative ciliary rootlet coiled-coil protein 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CROCC2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:51677 CROCC2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_H7BZ55

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000226321

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CROCC2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004226131 – 1655Putative ciliary rootlet coiled-coil protein 2Add BLAST1655

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
H7BZ55

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
H7BZ55

PRoteomics IDEntifications database

More...
PRIDEi
H7BZ55

ProteomicsDB human proteome resource

More...
ProteomicsDBi
43840

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
H7BZ55

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000226321 Expressed in 63 organ(s), highest expression level in right uterine tube

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048678

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
H7BZ55, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000397968

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H7BZ55

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili83 – 196Sequence analysisAdd BLAST114
Coiled coili308 – 351Sequence analysisAdd BLAST44
Coiled coili417 – 1297Sequence analysisAdd BLAST881
Coiled coili1363 – 1641Sequence analysisAdd BLAST279

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi227 – 230Poly-LeuSequence analysis4
Compositional biasi646 – 881Gln-richPROSITE-ProRule annotationAdd BLAST236
Compositional biasi1540 – 1653Gln-richPROSITE-ProRule annotationAdd BLAST114

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rootletin family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFAN Eukaryota
ENOG410XPG3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162689

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H7BZ55

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHMKKAN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H7BZ55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSASSEPGN GDASQQPLLG LDTVIQRLED TILSPTASRE DRALTVRGEG
60 70 80 90 100
RQASPTPVPT RIREIVAGSL SEEPPQAGVQ EPTATVARVQ EENELLQEEL
110 120 130 140 150
TRLGDLLAQA SAERDELASR CRVVSEQLQA RLETTEAQLR RSELEHSVDL
160 170 180 190 200
EEALGRLEAA EERSTGLCQV NALLREQLEH MKKANDALGR ELAGMTGSVQ
210 220 230 240 250
RLQGELELRR WAQRQTRSGG LGQPRDLLLL WRQAVVLGTD LAELRVATER
260 270 280 290 300
GLADLQADTA RTARRLHTAC LNLDSNLRLS ASSTASTLGQ QLRDKAGEML
310 320 330 340 350
QLQGRWDAEK VALQARLSEQ TLLVEKLTEQ NEQKAKTIAA LRTDLQNLVA
360 370 380 390 400
QEDARCLELA GSSITELGEP RRPLRSPQRA TSPHQGASPP HICSPATLDP
410 420 430 440 450
ALQAMRAAIE RRWRREQELC LQLKSSQALV ASLQEQLSES RRELWAAQKL
460 470 480 490 500
QQERAREQAR EREALRGQLE AQRLEVQQCR ASCKLLGREK AALEMVVEEL
510 520 530 540 550
KGKADAADAE KQGLEAEAAE LQRSLLLQAE RREELALRRE RSCRALETSQ
560 570 580 590 600
GRLQQLEEKV SGLREELASV REALSTAQLQ RDVVESEREG LRSALARAEC
610 620 630 640 650
SNADLELLVR RLKSEGVEQR DSLAAMAALM EGLAQDKSAL NHLALQLEQE
660 670 680 690 700
RDQLREQRKT LEQERARAGE QLAQAEQQLA LERAERRGLQ QACGRLEQRQ
710 720 730 740 750
EQLEGQAALL GREKAQLQEQ VGQVTCQKQA LEEQLAQSLQ DQEAQMGTLQ
760 770 780 790 800
QALQGKDALS EERAQLLAKQ EALERQGRLA AEEAADLRVE RDSLESSLLE
810 820 830 840 850
AQQLATKLQE QLEEEARSAG LARQALQVEM EQLQSDWEVQ EMKLRQDTVR
860 870 880 890 900
LQRQVAQQER EAQRALESQA LAHREALAQL QREKETLSLT LAEEKEVARC
910 920 930 940 950
QLEQEKELVT KSAAEREALK GEIQSLKQER DESLLQLEHK MQQVMALSLK
960 970 980 990 1000
ETERSLLSEE LSRARRTLER VQQEAQSQQE QAQATISATT EELKALQAQF
1010 1020 1030 1040 1050
EDAITAHQRE TTALRESLQD LAAERGDVER EAERLRAQLT VAQEGLAALR
1060 1070 1080 1090 1100
QELQGVEESR EGLHREAQEA RRALSDEARE KDVLLLFNSE LRATICRAEQ
1110 1120 1130 1140 1150
EKASFKRSKE EKEQKLLILE EAQAALQQEA SALRAHLWEL EQAGGDARQE
1160 1170 1180 1190 1200
LRELHRQVRT LKAENQRRSG EAHELQAQCS QEVLELRRQA AKAEAKHEGA
1210 1220 1230 1240 1250
RKEVLGLQRK LAEVEAAGEA HGQRLQEHLR ESRGAEQTLR AELHSVTRKL
1260 1270 1280 1290 1300
QEASGVADAL QARLDQACHR IHSLEQELAQ AEGARQDAEA QLGRLCSTLR
1310 1320 1330 1340 1350
RGLGLQRQSP WASPEQPGSP TKGSDSSQAL PGQQGTSPPA RPHSPLRWPS
1360 1370 1380 1390 1400
PTPGGRSSEL MDVATVQDIL RDFVQKLREA QRERDDSRIQ MATLSSRLSE
1410 1420 1430 1440 1450
AECRCARAQS RVGQLQKALA EAEEGQRRVE GALSSARAAR ALQKEALRRL
1460 1470 1480 1490 1500
ELEHLASVRA AGQEKRRLQE QLETLRQALE ESRRHSQGLA KQGKLLEEQL
1510 1520 1530 1540 1550
TNLEHRCQKA EVSLEPLRQM EQETLKREED VARLGAEKEQ LDQSLNSLHQ
1560 1570 1580 1590 1600
EVDGALRQNQ QLQAQMTEME QAHTQRLQDL TAQHQRDLAT EAERLHGARP
1610 1620 1630 1640 1650
QATQALESQE WTHQQQVKVL EEQVASLKEQ LDQEVQWRQQ AHLGQAFQTG

HAQRD
Length:1,655
Mass (Da):185,872
Last modified:April 1, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5693C1B5B0560571
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC104809 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000443866; ENSP00000397968; ENSG00000226321

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104809 Genomic DNA No translation available.

3D structure databases

SMRiH7BZ55
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiH7BZ55, 1 interactor
STRINGi9606.ENSP00000397968

PTM databases

PhosphoSitePlusiH7BZ55

Polymorphism and mutation databases

BioMutaiCROCC2

Proteomic databases

jPOSTiH7BZ55
PaxDbiH7BZ55
PRIDEiH7BZ55
ProteomicsDBi43840

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000443866; ENSP00000397968; ENSG00000226321

Organism-specific databases

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CROCC2
HGNCiHGNC:51677 CROCC2
HPAiHPA048678
neXtProtiNX_H7BZ55
OpenTargetsiENSG00000226321

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFAN Eukaryota
ENOG410XPG3 LUCA
GeneTreeiENSGT00940000162689
InParanoidiH7BZ55
OMAiEHMKKAN

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CROCC2 human

Gene expression databases

BgeeiENSG00000226321 Expressed in 63 organ(s), highest expression level in right uterine tube

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRCC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H7BZ55
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: April 1, 2015
Last modified: May 8, 2019
This is version 51 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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