UniProtKB - H7BYT1 (H7BYT1_HUMAN)
Protein
Submitted name:
Casein kinase I isoform delta
Gene
CSNK1D
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: UniProtKB-KW
GO - Biological processi
- cellular response to nerve growth factor stimulus Source: Ensembl
- circadian regulation of gene expression Source: Ensembl
- non-motile cilium assembly Source: Ensembl
- positive regulation of non-canonical Wnt signaling pathway Source: Ensembl
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
- regulation of circadian rhythm Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Casein kinase I isoform deltaImported |
Gene namesi | Name:CSNK1DImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2452 CSNK1D |
Subcellular locationi
Cytoskeleton
- centrosome Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- neuron projection Source: Ensembl
- perinuclear region of cytoplasm Source: Ensembl
PTM / Processingi
Proteomic databases
EPDi | H7BYT1 |
jPOSTi | H7BYT1 |
MaxQBi | H7BYT1 |
PeptideAtlasi | H7BYT1 |
PRIDEi | H7BYT1 |
ProteomicsDBi | 43724 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141551 Expressed in 227 organ(s), highest expression level in adenohypophysis |
ExpressionAtlasi | H7BYT1 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 277 | Protein kinaseInterPro annotationAdd BLAST | 269 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 301 – 404 | DisorderedSequence analysisAdd BLAST | 104 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 301 – 320 | PolyampholyteSequence analysisAdd BLAST | 20 | |
Compositional biasi | 342 – 359 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 380 – 404 | PolarSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Phylogenomic databases
eggNOGi | KOG1164 Eukaryota ENOG410XPGP LUCA |
GeneTreei | ENSGT00940000153536 |
OMAi | IYFCRGS |
OrthoDBi | 1097975at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069 Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220 S_TKc, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
H7BYT1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH
60 70 80 90 100
IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF
110 120 130 140 150
SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF
160 170 180 190 200
GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG
210 220 230 240 250
YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT
260 270 280 290 300
YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA
310 320 330 340 350
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS
360 370 380 390 400
HTANTSPRPV SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQR
410 420
SRDMASLRLH AARQGTRCRP QRPRRTY
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP48730 | KC1D_HUMAN | Casein kinase I isoform delta | CSNK1D HCKID | 415 | Annotation score: | ||
J3KRM8 | J3KRM8_HUMAN | Casein kinase I isoform delta | CSNK1D | 64 | Annotation score: | ||
B4DLF1 | B4DLF1_HUMAN | Casein kinase I isoform delta | CSNK1D | 126 | Annotation score: | ||
J3QQI9 | J3QQI9_HUMAN | Casein kinase I isoform delta | CSNK1D | 187 | Annotation score: | ||
H0Y2N6 | H0Y2N6_HUMAN | Casein kinase I isoform delta | CSNK1D | 120 | Annotation score: | ||
J3KRS6 | J3KRS6_HUMAN | Casein kinase I isoform delta | CSNK1D | 56 | Annotation score: | ||
J3QS70 | J3QS70_HUMAN | Casein kinase I isoform delta | CSNK1D | 43 | Annotation score: | ||
J3QQU8 | J3QQU8_HUMAN | Casein kinase I isoform delta | CSNK1D | 20 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC132872 Genomic DNA No translation available. |
RefSeqi | XP_005256394.1, XM_005256337.4 |
Genome annotation databases
Ensembli | ENST00000398519; ENSP00000381531; ENSG00000141551 |
UCSCi | uc060lxq.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC132872 Genomic DNA No translation available. |
RefSeqi | XP_005256394.1, XM_005256337.4 |
3D structure databases
SMRi | H7BYT1 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | H7BYT1, 1 interactor |
Proteomic databases
EPDi | H7BYT1 |
jPOSTi | H7BYT1 |
MaxQBi | H7BYT1 |
PeptideAtlasi | H7BYT1 |
PRIDEi | H7BYT1 |
ProteomicsDBi | 43724 |
Genome annotation databases
Ensembli | ENST00000398519; ENSP00000381531; ENSG00000141551 |
UCSCi | uc060lxq.1 human |
Organism-specific databases
CTDi | 1453 |
HGNCi | HGNC:2452 CSNK1D |
OpenTargetsi | ENSG00000141551 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1164 Eukaryota ENOG410XPGP LUCA |
GeneTreei | ENSGT00940000153536 |
OMAi | IYFCRGS |
OrthoDBi | 1097975at2759 |
Miscellaneous databases
ChiTaRSi | CSNK1D human |
GenomeRNAii | 1453 |
Gene expression databases
Bgeei | ENSG00000141551 Expressed in 227 organ(s), highest expression level in adenohypophysis |
ExpressionAtlasi | H7BYT1 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069 Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220 S_TKc, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H7BYT1_HUMAN | |
Accessioni | H7BYT1Primary (citable) accession number: H7BYT1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | October 16, 2019 | |
This is version 67 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |