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UniProtKB - H7BYP1 (H7BYP1_HUMAN)
Protein
Submitted name:
Transient receptor potential cation channel subfamily M member 3
Gene
TRPM3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calcium activated cation channel activity Source: InterPro
GO - Biological processi
- detection of temperature stimulus Source: InterPro
- protein tetramerization Source: InterPro
- sensory perception of temperature stimulus Source: InterPro
Keywordsi
Molecular function | ReceptorImported |
Biological process | Ion transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Transient receptor potential cation channel subfamily M member 3ImportedSubmitted name: Transient receptor potential cation channel, subfamily M, member 3, isoform CRA_cImported |
Gene namesi | Name:TRPM3Imported ORF Names:hCG_2042991Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17992, TRPM3 |
VEuPathDBi | HostDB:ENSG00000083067 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 722 – 741 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 789 – 807 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 819 – 837 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 858 – 878 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 936 – 961 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000083067, Expressed in pigmented layer of retina and 162 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 265 | LSDAT_eukInterPro annotationAdd BLAST | 265 | |
Domaini | 728 – 970 | Ion_transInterPro annotationAdd BLAST | 243 | |
Domaini | 1064 – 1119 | TRPM_tetraInterPro annotationAdd BLAST | 56 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1283 – 1302 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1435 – 1556 | DisorderedSequence analysisAdd BLAST | 122 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1067 – 1087 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1105 – 1125 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1283 – 1298 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1435 – 1454 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1460 – 1482 | Polar residuesSequence analysisAdd BLAST | 23 |
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157366 |
OrthoDBi | 738147at2759 |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029583, TRPM3 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF7, PTHR13800:SF7, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
H7BYP1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYVRVSFDTK PDLLLHLMTK EWQLELPKLL ISVHGGLQNF ELQPKLKQVF
60 70 80 90 100
GKGLIKAAMT TGAWIFTGGV NTGVIRHVGD ALKDHASKSR GKICTIGIAP
110 120 130 140 150
WGIVENQEDL IGRDVVRPYQ TMSNPMSKLT VLNSMHSHFI LADNGTTGKY
160 170 180 190 200
GAEVKLRRQL EKHISLQKIN TRIGQGVPVV ALIVEGGPNV ISIVLEYLRD
210 220 230 240 250
TPPVPVVVCD GSGRASDILA FGHKYSEEGG LINESLRDQL LVTIQKTFTY
260 270 280 290 300
TRTQAQHLFI ILMECMKKKE LITVFRMGSE GHQDIDLAIL TALLKGANAS
310 320 330 340 350
APDQLSLALA WNRVDIARSQ IFIYGQQWPV GSLEQAMLDA LVLDRVDFVK
360 370 380 390 400
LLIENGVSMH RFLTISRLEE LYNTRHGPSN TLYHLVRDVK KREYPGFGWI
410 420 430 440 450
YFKGNLPPDY RISLIDIGLV IEYLMGGAYR CNYTRKRFRT LYHNLFGPKR
460 470 480 490 500
DDIPLRRGRK TTKKREEEVD IDLDDPEINH FPFPFHELMV WAVLMKRQKM
510 520 530 540 550
ALFFWQHGEE AMAKALVACK LCKAMAHEAS ENDMVDDISQ ELNHNSRDFG
560 570 580 590 600
QLAVELLDQS YKQDEQLAMK LLTYELKNWS NATCLQLAVA AKHRDFIAHT
610 620 630 640 650
CSQMLLTDMW MGRLRMRKNS GLKVILGILL PPSILSLEFK NKDDMPYMSQ
660 670 680 690 700
AQEIHLQEKE AEEPEKPTKE KEEEDMELTA MLGRNNGESS RKKDEEEVQS
710 720 730 740 750
KHRLIPLGRK IYEFYNAPIV KFWFYTLAYI GYLMLFNYIV LVKMERWPST
760 770 780 790 800
QEWIVISYIF TLGIEKMREI LMSEPGKLLQ KVKVWLQEYW NVTDLIAILL
810 820 830 840 850
FSVGMILRLQ DQPFRSDGRV IYCVNIIYWY IRLLDIFGVN KYLGPYVMMI
860 870 880 890 900
GKMMIDMMYF VIIMLVVLMS FGVARQAILF PNEEPSWKLA KNIFYMPYWM
910 920 930 940 950
IYGEVFADQI DPPCGQNETR EDGKIIQLPP CKTGAWIVPA IMACYLLVAN
960 970 980 990 1000
ILLVNLLIAV FNNTFFEVKS ISNQVWKFQR YQLIMTFHER PVLPPPLIIF
1010 1020 1030 1040 1050
SHMTMIFQHL CCRWRKHESD PDERDYGLKL FITDDELKKV HDFEEQCIEE
1060 1070 1080 1090 1100
YFREKDDRFN SSNDERIRVT SERVENMSMR LEEVNEREHS MKASLQTVDI
1110 1120 1130 1140 1150
RLAQLEDLIG RMATALERLT GLERAESNKI RSRTSSDCTD AAYIVRQSSF
1160 1170 1180 1190 1200
NSQEGNTFKL QESIDPAGEE TMSPTSPTLM PRMRSHSFYS VNMKDKGGIE
1210 1220 1230 1240 1250
KLESIFKERS LSLHRATSSH SVAKEPKAPA APANTLAIVP DSRRPSSCID
1260 1270 1280 1290 1300
IYVSAMDELH CDIDPLDNSV NILGLGEPSF STPVPSTAPS SSAYATLAPT
1310 1320 1330 1340 1350
DRPPSRSIDF EDITSMDTRS FSSDYTHLPE CQNPWDSEPP MYHTIERSKS
1360 1370 1380 1390 1400
SRYLATTPFL LEEAPIVKSH SFMFSPSRSY YANFGVPVKT AEYTSITDCI
1410 1420 1430 1440 1450
DTRCVNAPQA IADRAAFPGG LGDKVEDLTC CHPEREAELS HPSSDSEENE
1460 1470 1480 1490 1500
AKGRRATIAI SSQEGDNSER TLSNNITVPK IERANSYSAE EPSAPYAHTR
1510 1520 1530 1540 1550
KSFSISDKLD RQRNTASLRN PFQRSKSSKP EGRGDSLSMR RLSRTSAFQS
FESKHN
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9HCF6 | TRPM3_HUMAN | Transient receptor potential cation... | TRPM3 KIAA1616, LTRPC3 | 1,732 | Annotation score: | ||
E9PBI7 | E9PBI7_HUMAN | Transient receptor potential cation... | TRPM3 | 1,579 | Annotation score: | ||
A2A3F7 | A2A3F7_HUMAN | Transient receptor potential cation... | TRPM3 | 1,711 | Annotation score: | ||
A2A3F4 | A2A3F4_HUMAN | Transient receptor potential cation... | TRPM3 | 1,569 | Annotation score: | ||
G5E9G1 | G5E9G1_HUMAN | Transient receptor potential cation... | TRPM3 hCG_2042991 | 1,566 | Annotation score: | ||
A2A3F3 | A2A3F3_HUMAN | Transient receptor potential cation... | TRPM3 | 1,566 | Annotation score: | ||
A0A7I2V4E8 | A0A7I2V4E8_HUMAN | Transient receptor potential cation... | TRPM3 | 1,690 | Annotation score: | ||
A0A7I2V4C9 | A0A7I2V4C9_HUMAN | Transient receptor potential cation... | TRPM3 | 1,184 | Annotation score: | ||
H0Y3D4 | H0Y3D4_HUMAN | Transient receptor potential cation... | TRPM3 | 123 | Annotation score: | ||
Q4VXD4 | Q4VXD4_HUMAN | Transient receptor potential cation... | TRPM3 | 275 | Annotation score: | ||
There is more potential isoformShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL159990 Genomic DNA No translation available. AL160273 Genomic DNA No translation available. AL161913 Genomic DNA No translation available. AL356318 Genomic DNA No translation available. AL358786 Genomic DNA No translation available. AL391819 Genomic DNA No translation available. AL442645 Genomic DNA No translation available. AL592438 Genomic DNA No translation available. KF458923 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62507.1 |
RefSeqi | NP_996828.3, NM_206945.3 |
Genome annotation databases
Ensembli | ENST00000396280; ENSP00000379576; ENSG00000083067 |
GeneIDi | 80036 |
UCSCi | uc064trf.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL159990 Genomic DNA No translation available. AL160273 Genomic DNA No translation available. AL161913 Genomic DNA No translation available. AL356318 Genomic DNA No translation available. AL358786 Genomic DNA No translation available. AL391819 Genomic DNA No translation available. AL442645 Genomic DNA No translation available. AL592438 Genomic DNA No translation available. KF458923 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62507.1 |
RefSeqi | NP_996828.3, NM_206945.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 43684 |
Protocols and materials databases
Antibodypediai | 12418, 163 antibodies from 19 providers |
DNASUi | 80036 |
Genome annotation databases
Ensembli | ENST00000396280; ENSP00000379576; ENSG00000083067 |
GeneIDi | 80036 |
UCSCi | uc064trf.1, human |
Organism-specific databases
CTDi | 80036 |
HGNCi | HGNC:17992, TRPM3 |
OpenTargetsi | ENSG00000083067 |
VEuPathDBi | HostDB:ENSG00000083067 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157366 |
OrthoDBi | 738147at2759 |
Miscellaneous databases
BioGRID-ORCSi | 80036, 3 hits in 1039 CRISPR screens |
ChiTaRSi | TRPM3, human |
GenomeRNAii | 80036 |
Gene expression databases
Bgeei | ENSG00000083067, Expressed in pigmented layer of retina and 162 other tissues |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029583, TRPM3 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF7, PTHR13800:SF7, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H7BYP1_HUMAN | |
Accessioni | H7BYP1Primary (citable) accession number: H7BYP1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | September 18, 2013 | |
Last modified: | January 19, 2022 | |
This is version 75 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |