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Protein

Cysteine protease

Gene

ATG4A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation
Biological processAutophagyUniRule annotationSAAS annotation, Protein transportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine proteaseUniRule annotation (EC:3.4.22.-UniRule annotation)
Gene namesi
Name:ATG4AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000101844.17
HGNCiHGNC:16489 ATG4A

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101844

PTM / Processingi

Proteomic databases

MaxQBiH7BYM2
PeptideAtlasiH7BYM2
PRIDEiH7BYM2

Expressioni

Gene expression databases

BgeeiENSG00000101844 Expressed in 213 organ(s), highest expression level in biceps brachii
ExpressionAtlasiH7BYM2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7BYM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C54 family.UniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000063000

Family and domain databases

InterProiView protein in InterPro
IPR033474 ATG4A
IPR038765 Papain_like_cys_pep_sf
IPR005078 Peptidase_C54
PANTHERiPTHR22624 PTHR22624, 2 hits
PTHR22624:SF35 PTHR22624:SF35, 2 hits
PfamiView protein in Pfam
PF03416 Peptidase_C54, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H7BYM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XLSKYEDQIT IFTDYLEEYP DTDELVWILG KQHLLKTGGT GPSSDAGWGC
60 70 80 90 100
MLRCGQMMLA QALICRHLGR DWSWEKQKEQ PKEYQRILQC FLDRKDCCYS
110 120 130 140 150
IHQMAQMGVG EGKSIGEWFG PNTVAQVLKK LALFDEWNSL AVYVSMDNTV
160 170 180 190 200
VIEDIKKMCR VLPLSADTAG DRPPDSLTAS NQSKGTSAYC SAWKPLLLIV
210 220 230 240 250
PLRLGINQIN PVYVDAFKEC FKMPQSLGAL GGKPNNAYYF IGFLGDELIF
260 270 280 290 300
LDPHTTQTFV DTEENGTVND QTFHCLQSPQ RMNILNLDPS VALGFFCKEE
310
KDFDNWCSLV QK
Length:312
Mass (Da):35,252
Last modified:April 18, 2012 - v1
Checksum:i9193B66B429C7E60
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8WYN0ATG4A_HUMAN
Cysteine protease ATG4A
ATG4A APG4A, AUTL2
398Annotation score:
G5E979G5E979_HUMAN
Cysteine protease
ATG4A hCG_21686
231Annotation score:
A0A0A0MT61A0A0A0MT61_HUMAN
Cysteine protease
ATG4A
202Annotation score:
F8W7J2F8W7J2_HUMAN
Cysteine protease ATG4A
ATG4A
47Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei312Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031177 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000394892; ENSP00000378354; ENSG00000101844
UCSCiuc065aqc.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031177 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH7BYM2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH7BYM2
PeptideAtlasiH7BYM2
PRIDEiH7BYM2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394892; ENSP00000378354; ENSG00000101844
UCSCiuc065aqc.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000101844.17
HGNCiHGNC:16489 ATG4A
OpenTargetsiENSG00000101844
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063000

Gene expression databases

BgeeiENSG00000101844 Expressed in 213 organ(s), highest expression level in biceps brachii
ExpressionAtlasiH7BYM2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR033474 ATG4A
IPR038765 Papain_like_cys_pep_sf
IPR005078 Peptidase_C54
PANTHERiPTHR22624 PTHR22624, 2 hits
PTHR22624:SF35 PTHR22624:SF35, 2 hits
PfamiView protein in Pfam
PF03416 Peptidase_C54, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH7BYM2_HUMAN
AccessioniPrimary (citable) accession number: H7BYM2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 12, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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