UniProtKB - H7BYH4 (H7BYH4_HUMAN)
Protein
Superoxide dismutase [Cu-Zn]
Gene
SOD1
Organism
Homo sapiens (Human)
Status
Functioni
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation
Catalytic activityi
- EC:1.15.1.1UniRule annotation
Cofactori
Protein has several cofactor binding sites:- Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
- Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- superoxide dismutase activity Source: UniProtKB-EC
Keywordsi
Molecular function | OxidoreductaseUniRule annotation |
Ligand | CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SOD1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11179 SOD1 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
PTM / Processingi
Proteomic databases
jPOSTi | H7BYH4 |
MaxQBi | H7BYH4 |
PeptideAtlasi | H7BYH4 |
PRIDEi | H7BYH4 |
ProteomicsDBi | 43620 |
Expressioni
Gene expression databases
Bgeei | ENSG00000142168 Expressed in 236 organ(s), highest expression level in pons |
ExpressionAtlasi | H7BYH4 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 131 | Sod_CuInterPro annotationAdd BLAST | 127 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 43 – 62 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG0441 Eukaryota COG2032 LUCA |
GeneTreei | ENSGT00940000155551 |
Family and domain databases
CDDi | cd00305 Cu-Zn_Superoxide_Dismutase, 1 hit |
Gene3Di | 2.60.40.200, 1 hit |
InterProi | View protein in InterPro IPR036423 SOD-like_Cu/Zn_dom_sf IPR024134 SOD_Cu/Zn_/chaperone IPR018152 SOD_Cu/Zn_BS IPR001424 SOD_Cu_Zn_dom |
PANTHERi | PTHR10003 PTHR10003, 1 hit |
Pfami | View protein in Pfam PF00080 Sod_Cu, 1 hit |
PRINTSi | PR00068 CUZNDISMTASE |
SUPFAMi | SSF49329 SSF49329, 1 hit |
PROSITEi | View protein in PROSITE PS00087 SOD_CU_ZN_1, 1 hit PS00332 SOD_CU_ZN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
H7BYH4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATKAESNGP VKVWGSIKGL TEGLHGFHVH EFGDNTAGCT SAGPHFNPLS
60 70 80 90 100
RKHGGPKDEE RHVGDLGNVT ADKDGVADVS IEDSVISLSG DHCIIGRTLV
110 120 130
VHEKADDLGK GGNEESTKTG NAGSRLACGV IGIAQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP00441 | SODC_HUMAN | Superoxide dismutase [Cu-Zn] | SOD1 | 154 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000253 Genomic DNA No translation available. AP000254 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000389995; ENSP00000374645; ENSG00000142168 |
UCSCi | uc061zmk.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000253 Genomic DNA No translation available. AP000254 Genomic DNA No translation available. |
3D structure databases
SMRi | H7BYH4 |
ModBasei | Search... |
Proteomic databases
jPOSTi | H7BYH4 |
MaxQBi | H7BYH4 |
PeptideAtlasi | H7BYH4 |
PRIDEi | H7BYH4 |
ProteomicsDBi | 43620 |
Genome annotation databases
Ensembli | ENST00000389995; ENSP00000374645; ENSG00000142168 |
UCSCi | uc061zmk.1 human |
Organism-specific databases
HGNCi | HGNC:11179 SOD1 |
OpenTargetsi | ENSG00000142168 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0441 Eukaryota COG2032 LUCA |
GeneTreei | ENSGT00940000155551 |
Miscellaneous databases
ChiTaRSi | SOD1 human |
Gene expression databases
Bgeei | ENSG00000142168 Expressed in 236 organ(s), highest expression level in pons |
ExpressionAtlasi | H7BYH4 baseline and differential |
Family and domain databases
CDDi | cd00305 Cu-Zn_Superoxide_Dismutase, 1 hit |
Gene3Di | 2.60.40.200, 1 hit |
InterProi | View protein in InterPro IPR036423 SOD-like_Cu/Zn_dom_sf IPR024134 SOD_Cu/Zn_/chaperone IPR018152 SOD_Cu/Zn_BS IPR001424 SOD_Cu_Zn_dom |
PANTHERi | PTHR10003 PTHR10003, 1 hit |
Pfami | View protein in Pfam PF00080 Sod_Cu, 1 hit |
PRINTSi | PR00068 CUZNDISMTASE |
SUPFAMi | SSF49329 SSF49329, 1 hit |
PROSITEi | View protein in PROSITE PS00087 SOD_CU_ZN_1, 1 hit PS00332 SOD_CU_ZN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H7BYH4_HUMAN | |
Accessioni | H7BYH4Primary (citable) accession number: H7BYH4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | July 31, 2019 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |