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Protein
Submitted name:

PX domain-containing protein kinase-like protein

Gene

PXK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
PX domain-containing protein kinase-like proteinImported
Gene namesi
Name:PXKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000168297.15
HGNCiHGNC:23326 PXK

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168297

PTM / Processingi

Proteomic databases

MaxQBiH7BYG4
PeptideAtlasiH7BYG4
PRIDEiH7BYG4

Expressioni

Gene expression databases

BgeeiENSG00000168297 Expressed in 198 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH7BYG4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7BYG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 109PXInterPro annotationAdd BLAST109
Domaini71 – 464Protein kinaseInterPro annotationAdd BLAST394

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili399 – 419Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IF7B Eukaryota
ENOG410Z20X LUCA
GeneTreeiENSGT00390000017669

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001683 Phox
IPR000719 Prot_kinase_dom
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50195 PX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

H7BYG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTIVRRYS DFDLLNNSLQ
60 70 80 90 100
IAGLSLPLPP KKLIGNMDRE FIAERQKGLQ NYLNVITTNH ILSNCELVKK
110 120 130 140 150
FLDPNNYSAN YTEIALQQVS MFFRSEPKWE VVEPLKDIGW RIRKKYFLMK
160 170 180 190 200
IKNQPKERLV LSWADLGPDK YLSDKDFQCL IKLLPSCLHP YIYRVTFATA
210 220 230 240 250
NESSALLIRM FNEKGTLKDL IYKAKPKDPF LKKYCNPKKI QGLELQQIKT
260 270 280 290 300
YGRQILEVLK FLHDKGFPYG HLHASNVMLD GDTCRLLDLE NSLLGLPSFY
310 320 330 340 350
RSYFSQFRKI NTLESVDVHC FGHLLYEMTY GRPPDSVPVD SFPPAPSMAV
360 370 380 390 400
VAVLESTLSC EACKNGMPTI SRLLQMPLFS DVLLTTSEKP QFKIPTKLKE
410 420 430 440 450
ALRIAKECIE KRLIEEQKQI HQHRRLTRAQ SHHGSEEERK KRKILARKKS
460 470 480 490
KRSALENSEE HSAKYSNSNN SAGSGASSPL TSPSSPTPPS TSVEHAPF
Length:498
Mass (Da):56,673
Last modified:April 18, 2012 - v1
Checksum:i99674F016D2B5076
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z7A4PXK_HUMAN
PX domain-containing protein kinase...
PXK
578Annotation score:
W5RWE6W5RWE6_HUMAN
PX domain-containing protein kinase...
PXK
557Annotation score:
A0A0C4DG95A0A0C4DG95_HUMAN
PX domain-containing protein kinase...
PXK
563Annotation score:
E9PD56E9PD56_HUMAN
PX domain-containing protein kinase...
PXK
482Annotation score:
H7C4V0H7C4V0_HUMAN
PX domain-containing protein kinase...
PXK
312Annotation score:
U3KQS4U3KQS4_HUMAN
PX domain-containing protein kinase...
PXK
203Annotation score:
F8WDF7F8WDF7_HUMAN
PX domain-containing protein kinase...
PXK
141Annotation score:
C9IYJ2C9IYJ2_HUMAN
PX domain-containing protein kinase...
PXK
113Annotation score:
H7C4W2H7C4W2_HUMAN
PX domain-containing protein kinase...
PXK
85Annotation score:
H7C529H7C529_HUMAN
PX domain-containing protein kinase...
PXK
50Annotation score:
There is more potential isoformShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098479 Genomic DNA No translation available.
AC135507 Genomic DNA No translation available.
RefSeqiXP_016862170.1, XM_017006681.1

Genome annotation databases

EnsembliENST00000383715; ENSP00000373221; ENSG00000168297
UCSCiuc062kzu.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098479 Genomic DNA No translation available.
AC135507 Genomic DNA No translation available.
RefSeqiXP_016862170.1, XM_017006681.1

3D structure databases

ProteinModelPortaliH7BYG4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH7BYG4
PeptideAtlasiH7BYG4
PRIDEiH7BYG4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383715; ENSP00000373221; ENSG00000168297
UCSCiuc062kzu.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000168297.15
HGNCiHGNC:23326 PXK
OpenTargetsiENSG00000168297
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF7B Eukaryota
ENOG410Z20X LUCA
GeneTreeiENSGT00390000017669

Miscellaneous databases

ChiTaRSiPXK human

Gene expression databases

BgeeiENSG00000168297 Expressed in 198 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH7BYG4 baseline and differential

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001683 Phox
IPR000719 Prot_kinase_dom
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50195 PX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH7BYG4_HUMAN
AccessioniPrimary (citable) accession number: H7BYG4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 12, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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