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Protein
Submitted name:

Solute carrier family 15 member 4

Gene

SLC15A4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransportUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Solute carrier family 15 member 4Imported
Gene namesi
Name:SLC15A4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139370.10
HGNCiHGNC:23090 SLC15A4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 42HelicalSequence analysisAdd BLAST20
Transmembranei51 – 74HelicalSequence analysisAdd BLAST24
Transmembranei94 – 119HelicalSequence analysisAdd BLAST26
Transmembranei140 – 162HelicalSequence analysisAdd BLAST23
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139370

PTM / Processingi

Proteomic databases

MaxQBiH7BYB7
PeptideAtlasiH7BYB7
PRIDEiH7BYB7

Expressioni

Gene expression databases

BgeeiENSG00000139370 Expressed in 208 organ(s), highest expression level in blood
ExpressionAtlasiH7BYB7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7BYB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1237 Eukaryota
COG3104 LUCA
GeneTreeiENSGT00530000062961

Family and domain databases

InterProiView protein in InterPro
IPR036259 MFS_trans_sf
IPR000109 POT_fam
IPR018456 PTR2_symporter_CS
PANTHERiPTHR11654 PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854 PTR2, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS01023 PTR2_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H7BYB7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XSNLVLFLNG APFCWEGAQA SEALLLFMGL TYLGSPFGGW LADARLGRAR
60 70 80 90 100
AILLSLALYL LGMLAFPLLA APATRAALCG SARLLNCTAP GPDAAARCCS
110 120 130 140 150
PATFAGLVLV GLGVATVKAN ITPFGADQVK DRGPEATRRF FNWFYWSINL
160 170 180 190 200
GAILSLGGIA YIQQNVSFVT GYAIPTVCVG LAFVVFLCGQ SVFITKPPDG
210 220 230
SAFTDMFKIL TYSCCSQKRS GERQSNGCRQ HMFYRVFI
Length:238
Mass (Da):25,460
Last modified:April 18, 2012 - v1
Checksum:iD19482B926533DEC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8N697S15A4_HUMAN
Solute carrier family 15 member 4
SLC15A4 PHT1, PTR4, FP12591
577Annotation score:
B6ZDF2B6ZDF2_HUMAN
Solute carrier family 15 member 4
SLC15A4
155Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108704 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000376744; ENSP00000365935; ENSG00000139370
UCSCiuc058vcd.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108704 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH7BYB7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH7BYB7
PeptideAtlasiH7BYB7
PRIDEiH7BYB7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376744; ENSP00000365935; ENSG00000139370
UCSCiuc058vcd.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000139370.10
HGNCiHGNC:23090 SLC15A4
OpenTargetsiENSG00000139370
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1237 Eukaryota
COG3104 LUCA
GeneTreeiENSGT00530000062961

Miscellaneous databases

ChiTaRSiSLC15A4 human

Gene expression databases

BgeeiENSG00000139370 Expressed in 208 organ(s), highest expression level in blood
ExpressionAtlasiH7BYB7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036259 MFS_trans_sf
IPR000109 POT_fam
IPR018456 PTR2_symporter_CS
PANTHERiPTHR11654 PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854 PTR2, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS01023 PTR2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH7BYB7_HUMAN
AccessioniPrimary (citable) accession number: H7BYB7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: November 7, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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