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Entry version 67 (29 Sep 2021)
Sequence version 2 (02 Jun 2021)
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Protein
Submitted name:

Histone-lysine N-methyltransferase 2C

Gene

KMT2C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Histone-lysine N-methyltransferase 2CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KMT2CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13726, KMT2C

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000055609

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000055609

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H7BY37

PeptideAtlas

More...
PeptideAtlasi
H7BY37

PRoteomics IDEntifications database

More...
PRIDEi
H7BY37

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
43491

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000055609, Expressed in placenta and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H7BY37, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2995 – 3103PHD-typeInterPro annotationAdd BLAST109
Domaini3141 – 3201FYR N-terminalInterPro annotationAdd BLAST61
Domaini3202 – 3287FYR C-terminalInterPro annotationAdd BLAST86
Domaini3363 – 3476SETInterPro annotationAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31DisorderedSequence analysisAdd BLAST31
Regioni69 – 91DisorderedSequence analysisAdd BLAST23
Regioni138 – 168DisorderedSequence analysisAdd BLAST31
Regioni249 – 1013DisorderedSequence analysisAdd BLAST765
Regioni1061 – 1085DisorderedSequence analysisAdd BLAST25
Regioni1110 – 1233DisorderedSequence analysisAdd BLAST124
Regioni1331 – 1436DisorderedSequence analysisAdd BLAST106
Regioni1462 – 1506DisorderedSequence analysisAdd BLAST45
Regioni1530 – 1585DisorderedSequence analysisAdd BLAST56
Regioni1676 – 1715DisorderedSequence analysisAdd BLAST40
Regioni1750 – 1782DisorderedSequence analysisAdd BLAST33
Regioni1819 – 1846DisorderedSequence analysisAdd BLAST28
Regioni1864 – 1953DisorderedSequence analysisAdd BLAST90
Regioni2049 – 2419DisorderedSequence analysisAdd BLAST371
Regioni2488 – 2507DisorderedSequence analysisAdd BLAST20
Regioni2620 – 2650DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1596 – 1619Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 27Polar residuesSequence analysisAdd BLAST19
Compositional biasi75 – 89Pro residuesSequence analysisAdd BLAST15
Compositional biasi249 – 270Polar residuesSequence analysisAdd BLAST22
Compositional biasi271 – 298Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi299 – 388Polar residuesSequence analysisAdd BLAST90
Compositional biasi404 – 434Polar residuesSequence analysisAdd BLAST31
Compositional biasi459 – 505Polar residuesSequence analysisAdd BLAST47
Compositional biasi576 – 594Pro residuesSequence analysisAdd BLAST19
Compositional biasi652 – 671Polar residuesSequence analysisAdd BLAST20
Compositional biasi680 – 701Polar residuesSequence analysisAdd BLAST22
Compositional biasi711 – 740Polar residuesSequence analysisAdd BLAST30
Compositional biasi746 – 765Pro residuesSequence analysisAdd BLAST20
Compositional biasi771 – 794Polar residuesSequence analysisAdd BLAST24
Compositional biasi803 – 817Pro residuesSequence analysisAdd BLAST15
Compositional biasi818 – 832Polar residuesSequence analysisAdd BLAST15
Compositional biasi843 – 864Polar residuesSequence analysisAdd BLAST22
Compositional biasi872 – 919Polar residuesSequence analysisAdd BLAST48
Compositional biasi929 – 943Polar residuesSequence analysisAdd BLAST15
Compositional biasi972 – 988Pro residuesSequence analysisAdd BLAST17
Compositional biasi1063 – 1085Polar residuesSequence analysisAdd BLAST23
Compositional biasi1169 – 1189Polar residuesSequence analysisAdd BLAST21
Compositional biasi1202 – 1225Polar residuesSequence analysisAdd BLAST24
Compositional biasi1331 – 1350Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1351 – 1374Polar residuesSequence analysisAdd BLAST24
Compositional biasi1375 – 1389Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1390 – 1404Polar residuesSequence analysisAdd BLAST15
Compositional biasi1405 – 1424Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1530 – 1583Polar residuesSequence analysisAdd BLAST54
Compositional biasi1676 – 1714Polar residuesSequence analysisAdd BLAST39
Compositional biasi1759 – 1777Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1822 – 1844Pro residuesSequence analysisAdd BLAST23
Compositional biasi1905 – 1919Polar residuesSequence analysisAdd BLAST15
Compositional biasi1932 – 1953Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi2062 – 2093Polar residuesSequence analysisAdd BLAST32
Compositional biasi2108 – 2134Polar residuesSequence analysisAdd BLAST27
Compositional biasi2163 – 2246Polar residuesSequence analysisAdd BLAST84
Compositional biasi2250 – 2281Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi2340 – 2354Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2384 – 2419Basic and acidic residuesSequence analysisAdd BLAST36

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155281

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000065_3_1_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15697, ePHD2_KMT2C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR037877, KMT2C
IPR041968, KMT2C_ePHD2
IPR001214, SET_dom
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45888:SF1, PTHR45888:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00398, HMG, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095, SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 38 potential isoforms that are computationally mapped.Show allAlign All

H7BY37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XIGPVTDDPS SLPQPNVNQS SRPLSEEQLD GILSPELDKM VTDGAILGKL
60 70 80 90 100
YKIPELGGKD VEDLFTAVLS PANTQPTPLP QPPPPTQLLP IHNQDAFSRM
110 120 130 140 150
PLMNGLIGSS PHLPHNSLPP GSGLGTFSAI AQSSYPDARD KNSAFNPMAS
160 170 180 190 200
DPNNSWTSSA PTVEGENDTM SNAQRSTLKW EKEEALGEMA TVAPVLYTNI
210 220 230 240 250
NFPNLKEEFP DWTTRVKQIA KLWRKASSQE RAPYVQKARD NRAALRINKV
260 270 280 290 300
QMSNDSMKRQ QQQDSIDPSS RIDSELFKDP LKQRESEHEQ EWKFRQQMRQ
310 320 330 340 350
KSKQQAKIEA TQKLEQVKNE QQQQQQQQFG SQHLLVQSGS DTPSSGIQSP
360 370 380 390 400
LTPQPGNGNM SPAQSFHKEL FTKQPPSTPT STSSDDVFVK PQAPPPPPAP
410 420 430 440 450
SRIPIQDSLS QAQTSQPPSP QVFSPGSSNS RPPSPMDPYA KMVGTPRPPP
460 470 480 490 500
VGHSFSRRNS AAPVENCTPL SSVSRPLQMN ETTANRPSPV RDLCSSSTTN
510 520 530 540 550
NDPYAKPPDT PRPVMTDQFP KSLGLSRSPV VSEQTAKGPI AAGTSDHFTK
560 570 580 590 600
PSPRADVFQR QRIPDSYARP LLTPAPLDSG PGPFKTPMQP PPSSQDPYGS
610 620 630 640 650
VSQASRRLSV DPYERPALTP RPIDNFSHNQ SNDPYSQPPL TPHPAVNESF
660 670 680 690 700
AHPSRAFSQP GTISRPTSQD PYSQPPGTPR PVVDSYSQSS GTARSNTDPY
710 720 730 740 750
SQPPGTPRPT TVDPYSQQPQ TPRPSTQTDL FVTPVTNQRH SDPYAHPPGT
760 770 780 790 800
PRPGISVPYS QPPATPRPRI SEGFTRSSMT RPVLMPNQDP FLQAAQNRGP
810 820 830 840 850
ALPGPLVRPP DTCSQTPRPP GPGLSDTFSR VSPSAARDPY DQSPMTPRSQ
860 870 880 890 900
SDSFGTSQTA HDVADQPRPG SEGSFCASSN SPMHSQGQQF SGVSQLPGPV
910 920 930 940 950
PTSGVTDTQN TVNMAQADTE KLRQRQKLRE IILQQQQQKK IAGRQEKGSQ
960 970 980 990 1000
DSPAVPHPGP LQHWQPENVN QAFTRPPPPY PGNIRSPVAP PLGPRYAVFP
1010 1020 1030 1040 1050
KDQRGPYPPD VASMGMRPHG FRFGFPGGSH GTMPSQERFL VPPQQIQGSG
1060 1070 1080 1090 1100
VSPQLRRSVS VDMPRPLNNS QMNNPVGLPQ HFSPQSLPVQ QHNILGQAYI
1110 1120 1130 1140 1150
ELRHRAPDGR QRLPFSAPPG SVVEASSNLR HGNFIPRPDF PGPRHTDPMR
1160 1170 1180 1190 1200
RPPQGLPNQL PVHPDLEQVP PSQQEQGHSV HSSSMVMRTL NHPLGGEFSE
1210 1220 1230 1240 1250
APLSTSVPSE TTSDNLQITT QPSDGLEEKL DSDDPSVKEL DVKDLEGVEV
1260 1270 1280 1290 1300
KDLDDEDLEN LNLDTEDGKV VELDTLDNLE TNDPNLDDLL RSGEFDIIAY
1310 1320 1330 1340 1350
TDPELDMGDK KSMFNEELDL PIDDKLDNQC VSVEPKKKEQ ENKTLVLSDK
1360 1370 1380 1390 1400
HSPQKKSTVT NEVKTEVLSP NSKVESKCET EKNDENKDNV DTPCSQASAH
1410 1420 1430 1440 1450
SDLNDGEKTS LHPCDPDLFE KRTNRETAGP SANVIQASTQ LPAQDVINSC
1460 1470 1480 1490 1500
GITGSTPVLS SLLANEKSDN SDIRPSGSPP PPTLPASPSN HVSSLPPFIA
1510 1520 1530 1540 1550
PPGRVLDNAM NSNVTVVSRV NHVFSQGVQV NPGLIPGQST VNHSLGTGKP
1560 1570 1580 1590 1600
ATQTGPQTSQ SGTSSMSGPQ QLMIPQTLAQ QNRERPLLLE EQPLLLQDLL
1610 1620 1630 1640 1650
DQERQEQQQQ RQMQAMIRQR SEPFFPNIDF DAITDPIMKA KMVALKGINK
1660 1670 1680 1690 1700
VMAQNNLGMP PMVMSRFPFM GQVVTGTQNS EGQNLGPQAI PQDGSITHQI
1710 1720 1730 1740 1750
SRPNPPNFGP GFVNDSQRKQ YEEWLQETQQ LLQMQQKYLE EQIGAHRKSK
1760 1770 1780 1790 1800
KALSAKQRTA KKAGREFPEE DAEQLKHVTE QQSMVQKQLE QIRKQQKEHA
1810 1820 1830 1840 1850
ELIEDYRIKQ QQQCAMAPPT MMPSVQPQPP LIPGATPPTM SQPTFPMVPQ
1860 1870 1880 1890 1900
QLQHQQHTTV ISGHTSPVRM PSLPGWQPNS APAHLPLNPP RIQPPIAQLP
1910 1920 1930 1940 1950
IKTCTPAPGT VSNANPQSGP PPRVEFDDNN PFSESFQERE RKERLREQQE
1960 1970 1980 1990 2000
RQRIQLMQEV DRQRALQQRM EMEQHGMVGS EISSSRTSVS QIPFYSSDLP
2010 2020 2030 2040 2050
CDFMQPLGPL QQSPQHQQQM GQVLQQQNIQ QGSINSPSTQ TFMQTNERRQ
2060 2070 2080 2090 2100
VGPPSFVPDS PSIPVGSPNF SSVKQGHGNL SGTSFQQSPV RPSFTPALPA
2110 2120 2130 2140 2150
APPVANSSLP CGQDSTITHG HSYPGSTQSL IQLYSDIIPE EKGKKKRTRK
2160 2170 2180 2190 2200
KKRDDDAEST KAPSTPHSDI TAPPTPGISE TTSTPAVSTP SELPQQADQE
2210 2220 2230 2240 2250
SVEPVGPSTP NMAAGQLCTE LENKLPNSDF SQATPNQQTY ANSEVDKLSM
2260 2270 2280 2290 2300
ETPAKTEEIK LEKAETESCP GQEEPKLEEQ NGSKVEGNAV ACPVSSAQSP
2310 2320 2330 2340 2350
PHSAGAPAAK GDSGNELLKH LLKNKKSSSL LNQKPEGSIC SEDDCTKDNK
2360 2370 2380 2390 2400
LVEKQNPAEG LQTLGAQMQG GFGCGNQLPK TDGGSETKKQ RSKRTQRTGE
2410 2420 2430 2440 2450
KAAPRSKKRK KDEEEKQAMY SSTDTFTHLK QQLSLLPLME PIIGVNFAHF
2460 2470 2480 2490 2500
LPYGSGQFNS GNRLLGTFGS ATLEGVSDYY SQLIYKQNNL SNPPTPPASL
2510 2520 2530 2540 2550
PPTPPPMACQ KMANGFATTE ELAGKAGVLV SHEVTKTLGP KPFQLPFRPQ
2560 2570 2580 2590 2600
DDLLARALAQ GPKTVDVPAS LPTPPHNNQE ELRIQDHCGD RDTPDSFVPS
2610 2620 2630 2640 2650
SSPESVVGVE VSRYPDLSLV KEEPPEPVPS PIIPILPSTA GKSSESRRND
2660 2670 2680 2690 2700
IKTEPGTLYF ASPFGPSPNG PRSGLISVAI TLHPTAAENI SSVVAAFSDL
2710 2720 2730 2740 2750
LHVRIPNSYE VSSAPDVPSM GLVSSHRINP GLEYRQHLLL RGPPPGSANP
2760 2770 2780 2790 2800
PRLVSSYRLK QPNVPFPPTS NGLSGYKDSS HGIAESAALR PQWCCHCKVV
2810 2820 2830 2840 2850
ILGSGVRKSF KDLTLLNKDS RESTKRVEKD IVFCSNNCFI LYSSTAQAKN
2860 2870 2880 2890 2900
SENKESIPSL PQSPMRETPS KAFHQYSNNI STLDVHCLPQ LPEKASPPAS
2910 2920 2930 2940 2950
PPIAFPPAFE AAQVEAKPDE LKVTVKLKPR LRAVHGGFED CRPLNKKWRG
2960 2970 2980 2990 3000
MKWKKWSIHI VIPKGTFKPP CEDEIDEFLK KLGTSLKPDP VPKDYRKCCF
3010 3020 3030 3040 3050
CHEEGDGLTD GPARLLNLDL DLWVHLNCAL WSTEVYETQA GALINVELAL
3060 3070 3080 3090 3100
RRGLQMKCVF CHKTGATSGC HRFRCTNIYH FTCAIKAQCM FFKDKTMLCP
3110 3120 3130 3140 3150
MHKPKGIHEQ ELSYFAVFRR VYVQRDEVRQ IASIVQRGER DHTFRVGSLI
3160 3170 3180 3190 3200
FHTIGQLLPQ QMQAFHSPKA LFPVGYEASR LYWSTRYANR RCRYLCSIEE
3210 3220 3230 3240 3250
KDGRPVFVIR IVEQGHEDLV LSDISPKGVW DKILEPVACV RKKSEMLQLF
3260 3270 3280 3290 3300
PAYLKGEDLF GLTVSAVARI AESLPGVEAC ENYTFRYGRN PLMELPLAVN
3310 3320 3330 3340 3350
PTGCARSEPK MSAHVKRPHT LNSTSTSKSF QSTVTGELNA PYSKQFVHSK
3360 3370 3380 3390 3400
SSQYRKMKTE WKSNVYLARS RIQGLGLYAA RDIEKHTMVI EYIGTIIRNE
3410 3420 3430 3440 3450
VANRKEKLYE SQNRGVYMFR MDNDHVIDAT LTGGPARYIN HSCAPNCVAE
3460 3470
VVTFERGHKI IISSSRRIQK GEEVRV
Length:3,476
Mass (Da):382,282
Last modified:June 2, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55F36E478644A497
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 38 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NEZ4KMT2C_HUMAN
Histone-lysine N-methyltransferase ...
KMT2C HALR, KIAA1506, MLL3
4,911Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TAI3A0A7P0TAI3_HUMAN
[Histone H3]-lysine(4) N-trimethylt...
KMT2C
4,762Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y765H0Y765_HUMAN
Histone-lysine N-methyltransferase ...
KMT2C
1,766Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4Z5C9J4Z5_HUMAN
Histone-lysine N-methyltransferase ...
KMT2C
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNL4H0YNL4_HUMAN
Histone-lysine N-methyltransferase ...
KMT2C
914Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2V8H7C2V8_HUMAN
Histone-lysine N-methyltransferase ...
KMT2C
1,792Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C212H7C212_HUMAN
Histone-lysine N-methyltransferase ...
KMT2C
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T8F0A0A7P0T8F0_HUMAN
Histone-lysine N-methyltransferase ...
KMT2C
3,207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T9K8A0A7P0T9K8_HUMAN
Histone-lysine N-methyltransferase ...
KMT2C
3,211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TA60A0A7P0TA60_HUMAN
Histone-lysine N-methyltransferase ...
KMT2C
2,952Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC005631 Genomic DNA No translation available.
AC006017 Genomic DNA No translation available.
AC006474 Genomic DNA No translation available.
AC104692 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000360104; ENSP00000353218; ENSG00000055609

UCSC genome browser

More...
UCSCi
uc064jmk.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005631 Genomic DNA No translation available.
AC006017 Genomic DNA No translation available.
AC006474 Genomic DNA No translation available.
AC104692 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

MaxQBiH7BY37
PeptideAtlasiH7BY37
PRIDEiH7BY37
ProteomicsDBi43491

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33048, 88 antibodies

Genome annotation databases

EnsembliENST00000360104; ENSP00000353218; ENSG00000055609
UCSCiuc064jmk.1, human

Organism-specific databases

HGNCiHGNC:13726, KMT2C
OpenTargetsiENSG00000055609
VEuPathDBiHostDB:ENSG00000055609

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155281
HOGENOMiCLU_000065_3_1_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KMT2C, human

Gene expression databases

BgeeiENSG00000055609, Expressed in placenta and 230 other tissues
ExpressionAtlasiH7BY37, baseline and differential

Family and domain databases

CDDicd15697, ePHD2_KMT2C, 1 hit
Gene3Di1.10.30.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR037877, KMT2C
IPR041968, KMT2C_ePHD2
IPR001214, SET_dom
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45888:SF1, PTHR45888:SF1, 1 hit
PfamiView protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00398, HMG, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF47095, SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50280, SET, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH7BY37_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H7BY37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: June 2, 2021
Last modified: September 29, 2021
This is version 67 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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