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Entry version 70 (10 Feb 2021)
Sequence version 2 (29 Oct 2014)
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Protein
Submitted name:

Ryanodine receptor 2

Gene

RYR2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Calmodulin-bindingARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation, ReceptorARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ryanodine receptor 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RYR2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10484, RYR2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000198626.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4264 – 4283HelicalSequence analysisAdd BLAST20
Transmembranei4483 – 4503HelicalSequence analysisAdd BLAST21
Transmembranei4557 – 4576HelicalSequence analysisAdd BLAST20
Transmembranei4693 – 4714HelicalSequence analysisAdd BLAST22
Transmembranei4751 – 4772HelicalSequence analysisAdd BLAST22
Transmembranei4827 – 4850HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulumARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000198626

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
H7BY35

PRoteomics IDEntifications database

More...
PRIDEi
H7BY35

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
43489

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198626, Expressed in heart right ventricle and 162 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H7BY35, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini94 – 149MIRInterPro annotationAdd BLAST56
Domaini156 – 201MIRInterPro annotationAdd BLAST46
Domaini209 – 264MIRInterPro annotationAdd BLAST56
Domaini270 – 327MIRInterPro annotationAdd BLAST58
Domaini335 – 392MIRInterPro annotationAdd BLAST58
Domaini583 – 793B30.2/SPRYInterPro annotationAdd BLAST211
Domaini1009 – 1206B30.2/SPRYInterPro annotationAdd BLAST198
Domaini1321 – 1546B30.2/SPRYInterPro annotationAdd BLAST226
Domaini4007 – 4042EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1840 – 1875DisorderedSequence analysisAdd BLAST36
Regioni2338 – 2363DisorderedSequence analysisAdd BLAST26
Regioni4194 – 4213DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili456 – 476Sequence analysisAdd BLAST21
Coiled coili3042 – 3062Sequence analysisAdd BLAST21
Coiled coili3307 – 3327Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4196 – 4213PolyampholyteSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154906

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 2 hits
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50222, EF_HAND_2, 1 hit
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

H7BY35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DDEVVLQCTA TIHKEQQKLC LAAEGFGNRL CFLESTSNSK NVPPDLSICT
60 70 80 90 100
FVLEQSLSVR ALQEMLANTV EKSEGQVDVE KWLFSLKTAQ GGGHRTLLYG
110 120 130 140 150
HAILLRHSYS GMYLCCLSTS RSSTDKLAFD VGLQEDTTGE ACWWTIHPAS
160 170 180 190 200
KQRSEGEKVR VGDDLILVSV SSERYLHLSY GNGSLHVDAA FQQTLWSVAP
210 220 230 240 250
ISSGSEAAQG YLIGGDVLRL LHGHMDECLT VPSGEHGEEQ RRTVHYEGGA
260 270 280 290 300
VSVHARSLWR LETLRVAWSG SHIRWGQPFR LRHVTTGKYL SLMEDKNLLL
310 320 330 340 350
MDKEKADVKS TAFTFRSSKE KLDVGVRKEV DGMGTSEIKY GDSVCYIQHV
360 370 380 390 400
DTGLWLTYQS VDVKSVRMGS IQRKAIMHHE GHMDDGISLS RSQHEESRTA
410 420 430 440 450
RVIRSTVFLF NRFIRGLDAL SKKAKASTVD LPIESVSLSL QDLIGYFHPP
460 470 480 490 500
DEHLEHEDKQ NRLRALKNRQ NLFQEEGMIN LVLECIDRLH VYSSAAHFAD
510 520 530 540 550
VAGREAGESW KSILNSLYEL LAALIRGNRK NCAQFSGSLD WLISRLERLE
560 570 580 590 600
ASSGILEVLH CVLVESPEAL NIIKEGHIKS IISLLDKHGR NHKVLDVLCS
610 620 630 640 650
LCVCHGVAVR SNQHLICDNL LPGRDLLLQT RLVNHVSSMR PNIFLGVSEG
660 670 680 690 700
SAQYKKWYYE LMVDHTEPFV TAEATHLRVG WASTEGYSPY PGGGEEWGGN
710 720 730 740 750
GVGDDLFSYG FDGLHLWSGC IARTVSSPNQ HLLRTDDVIS CCLDLSAPSI
760 770 780 790 800
SFRINGQPVQ GMFENFNIDG LFFPVVSFSA GIKVRFLLGG RHGEFKFLPP
810 820 830 840 850
PGYAPCYEAV LPKEKLKVEH SREYKQERTY TRDLLGPTVS LTQAAFTPIP
860 870 880 890 900
VDTSQIVLPP HLERIREKLA ENIHELWVMN KIELGWQYGP VRDDNKRQHP
910 920 930 940 950
CLVEFSKLPE QERNYNLQMS LETLKTLLAL GCHVGISDEH AEDKVKKMKL
960 970 980 990 1000
PKNYQLTSGY KPAPMDLSFI KLTPSQEAMV DKLAENAHNV WARDRIRQGW
1010 1020 1030 1040 1050
TYGIQQDVKN RRNPRLVPYT LLDDRTKKSN KDSLREAVRT LLGYGYNLEA
1060 1070 1080 1090 1100
PDQDHAARAE VCSGTGERFR IFRAEKTYAV KAGRWYFEFE TVTAGDMRVG
1110 1120 1130 1140 1150
WSRPGCQPDQ ELGSDERAFA FDGFKAQRWH QGNEHYGRSW QAGDVVGCMV
1160 1170 1180 1190 1200
DMNEHTMMFT LNGEILLDDS GSELAFKDFD VGDGFIPVCS LGVAQVGRMN
1210 1220 1230 1240 1250
FGKDVSTLKY FTICGLQEGY EPFAVNTNRD ITMWLSKRLP QFLQVPSNHE
1260 1270 1280 1290 1300
HIEVTRIDGT IDSSPCLKVT QKSFGSQNSN TDIMFYRLSM PIECAEVFSK
1310 1320 1330 1340 1350
TVAGGLPGAG LFGPKNDLED YDADSDFEVL MKTAHGHLVP DRVDKDKEAT
1360 1370 1380 1390 1400
KPEFNNHKDY AQEKPSRLKQ RFLLRRTKPD YSTSHSARLT EDVLADDRDD
1410 1420 1430 1440 1450
YDFLMQTSTY YYSVRIFPGQ EPANVWVGWI TSDFHQYDTG FDLDRVRTVT
1460 1470 1480 1490 1500
VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE IGCVVDAASG
1510 1520 1530 1540 1550
LLTFIANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL
1560 1570 1580 1590 1600
SAGLFKSEHK NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV DVSRISERQG
1610 1620 1630 1640 1650
WLVQCLDPLQ FMSLHIPEEN RSVDILELTE QEELLKFHYH TLRLYSAVCA
1660 1670 1680 1690 1700
LGNHRVAHAL CSHVDEPQLL YAIENKYMPG LLRAGYYDLL IDIHLSSYAT
1710 1720 1730 1740 1750
ARLMMNNEYI VPMTEETKSI TLFPDENKKH GLPGIGLSTS LRPRMQFSSP
1760 1770 1780 1790 1800
SFVSISNECY QYSPEFPLDI LKSKTIQMLT EAVKEGSLHA RDPVGGTTEF
1810 1820 1830 1840 1850
LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPSVFKEAAT PEEESDTLEK
1860 1870 1880 1890 1900
ELSVDDAKLQ GAGEEEAKGG KRPKEGLLQM KLPEPVKLQM CLLLQYLCDC
1910 1920 1930 1940 1950
QVRHRIEAIV AFSDDFVAKL QDNQRFRYNE VMQALNMSAA LTARKTKEFR
1960 1970 1980 1990 2000
SPPQEQINML LNFKDDKSEC PCPEEIRDQL LDFHEDLMTH CGIELDEDGS
2010 2020 2030 2040 2050
LDGNSDLTIR GRLLSLVEKV TYLKKKQAEK PVESDSKKSS TLQQLISETM
2060 2070 2080 2090 2100
VRWAQESVIE DPELVRAMFV LLHRQYDGIG GLVRALPKTY TINGVSVEDT
2110 2120 2130 2140 2150
INLLASLGQI RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY QHPNLMRALG
2160 2170 2180 2190 2200
MHETVMEVMV NVLGGGESKE ITFPKMVANC CRFLCYFCRI SRQNQKAMFD
2210 2220 2230 2240 2250
HLSYLLENSS VGLASPAMRG STPLDVAAAS VMDNNELALA LREPDLEKVV
2260 2270 2280 2290 2300
RYLAGCGLQS CQMLVSKGYP DIGWNPVEGE RYLDFLRFAV FCNGESVEEN
2310 2320 2330 2340 2350
ANVVVRLLIR RPECFGPALR GEGGNGLLAA MEEAIKIAED PSRDGPSPNS
2360 2370 2380 2390 2400
GSSKTLDTEE EEDDTIHMGN AIMTFYSALI DLLGRCAPEM HLIHAGKGEA
2410 2420 2430 2440 2450
IRIRSILRSL IPLGDLVGVI SIAFQMPTIA KDGNVVEPDM SAGFCPDHKA
2460 2470 2480 2490 2500
AMVLFLDRVY GIEVQDFLLH LLEVGFLPDL RAAASLDTAA LSATDMALAL
2510 2520 2530 2540 2550
NRYLCTAVLP LLTRCAPLFA GTEHHASLID SLLHTVYRLS KGCSLTKAQR
2560 2570 2580 2590 2600
DSIEVCLLSI CGQLRPSMMQ HLLRRLVFDV PLLNEHAKMP LKLLTNHYER
2610 2620 2630 2640 2650
CWKYYCLPGG WGNFGAASEE ELHLSRKLFW GIFDALSQKK YEQELFKLAL
2660 2670 2680 2690 2700
PCLSAVAGAL PPDYMESNYV SMMEKQSSMD SEGNFNPQPV DTSNITIPEK
2710 2720 2730 2740 2750
LEYFINKYAE HSHDKWSMDK LANGWIYGEI YSDSSKVQPL MKPYKLLSEK
2760 2770 2780 2790 2800
EKEIYRWPIK ESLKTMLAWG WRIERTREGD SMALYNRTRR ISQTSQVSVD
2810 2820 2830 2840 2850
AAHGYSPRAI DMSNVTLSRD LHAMAEMMAE NYHNIWAKKK KMELESKGGG
2860 2870 2880 2890 2900
NHPLLVPYDT LTAKEKAKDR EKAQDILKFL QINGYAVSRG FKDLELDTPS
2910 2920 2930 2940 2950
IEKRFAYSFL QQLIRYVDEA HQYILEFDGG SRGKGEHFPY EQEIKFFAKV
2960 2970 2980 2990 3000
VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA SNKEKEMVTS LFCKLGVLVR
3010 3020 3030 3040 3050
HRISLFGNDA TSIVNCLHIL GQTLDARTVM KTGLESVKSA LRAFLDNAAE
3060 3070 3080 3090 3100
DLEKTMENLK QGQFTHTRNQ PKGVTQIINY TTVALLPMLS SLFEHIGQHQ
3110 3120 3130 3140 3150
FGEDLILEDV QVSCYRILTS LYALGTSKSI YVERQRSALG ECLAAFAGAF
3160 3170 3180 3190 3200
PVAFLETHLD KHNIYSIYNT KSSRERAALS LPTNVEDVCP NIPSLEKLME
3210 3220 3230 3240 3250
EIVELAESGI RYTQMPHVME VILPMLCSYM SRWWEHGPEN NPERAEMCCT
3260 3270 3280 3290 3300
ALNSEHMNTL LGNILKIIYN NLGIDEGAWM KRLAVFSQPI INKVKPQLLK
3310 3320 3330 3340 3350
THFLPLMEKL KKKAATVVSE EDHLKAEARG DMSEAELLIL DEFTTLARDL
3360 3370 3380 3390 3400
YAFYPLLIRF VDYNRAKWLK EPNPEAEELF RMVAEVFIYW SKSHNFKREE
3410 3420 3430 3440 3450
QNFVVQNEIN NMSFLITDTK SKMSKAAVSD QERKKMKRKG DRYSMQTSLI
3460 3470 3480 3490 3500
VAALKRLLPI GLNICAPGDQ ELIALAKNRF SLKDTEDEVR DIIRSNIHLQ
3510 3520 3530 3540 3550
GKLEDPAIRW QMALYKDLPN RTDDTSDPEK TVERVLDIAN VLFHLEQKSK
3560 3570 3580 3590 3600
RVGRRHYCLV EHPQRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPRHRA
3610 3620 3630 3640 3650
VNLFLQGYEK SWIETEEHYF EDKLIEDLAK PGAEPPEEDE GTKRVDPLHQ
3660 3670 3680 3690 3700
LILLFSRTAL TEKCKLEEDF LYMAYADIMA KSCHDEEDDD GEEEVKSFEE
3710 3720 3730 3740 3750
KEMEKQKLLY QQARLHDRGA AEMVLQTISA SKGETGPMVA ATLKLGIAIL
3760 3770 3780 3790 3800
NGGNSTVQQK MLDYLKEKKD VGFFQSLAGL MQSCSVLDLN AFERQNKAEG
3810 3820 3830 3840 3850
LGMVTEEGSG EKVLQDDEFT CDLFRFLQLL CEGHNSDFQN YLRTQTGNNT
3860 3870 3880 3890 3900
TVNIIISTVD YLLRVQESIS DFYWYYSGKD VIDEQGQRNF SKAIQVAKQV
3910 3920 3930 3940 3950
FNTLTEYIQG PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM KLSQDSSQIE
3960 3970 3980 3990 4000
LLKELMDLQK DMVVMLLSML EGNVVNGTIG KQMVDMLVES SNNVEMILKF
4010 4020 4030 4040 4050
FDMFLKLKDL TSSDTFKEYD PDGKGVISKR DFHKAMESHK HYTQSETEFL
4060 4070 4080 4090 4100
LSCAETDENE TLDYEEFVKR FHEPAKDIGF NVAVLLTNLS EHMPNDTRLQ
4110 4120 4130 4140 4150
TFLELAESVL NYFQPFLGRI EIMGSAKRIE RVYFEISESS RTQWEKPQVK
4160 4170 4180 4190 4200
ESKRQFIFDV VNEGGEKEKM ELFVNFCEDT IFEMQLAAQI SESDLNERSA
4210 4220 4230 4240 4250
NKEESEKERP EEQGPRMAFF SILTVRSALF ALRYNILTLM RMLSLKSLKK
4260 4270 4280 4290 4300
QMKKVKKMTV KDMVTAFFSS YWSIFMTLLH FVASVFRGFF RIICSLLLGG
4310 4320 4330 4340 4350
SLVEGAKKIK VAELLANMPD PTQDEVRGDG EEGERKPLEA ALPSEDLTDL
4360 4370 4380 4390 4400
KELTEESDLL SDIFGLDLKR EGGQYKLIPH NPNAGLSDLM SNPVPMPEVQ
4410 4420 4430 4440 4450
EKFQVIYLVT AAFSRRAYVL FVCFHRGEDG EKEEKAKEDK GKQKLRQLHT
4460 4470 4480 4490 4500
HRYGEPEVPE SAFWKKIIAY QQKLLNYFAR NFYNMRMLAL FVAFAINFIL
4510 4520 4530 4540 4550
LFYKVSTSSV VEGKELPTRS SSENAKVTSL DSSSHRIIAV HYVLEESSGY
4560 4570 4580 4590 4600
MEPTLRILAI LHTVISFFCI IGYYCLKVPL VIFKREKEVA RKLEFDGLYI
4610 4620 4630 4640 4650
TEQPSEDDIK GQWDRLVINT QSFPNNYWDK FVKRKVMDKY GEFYGRDRIS
4660 4670 4680 4690 4700
ELLGMDKAAL DFSDAREKKK PKKDSSLSAV LNSIDVKYQM WKLGVVFTDN
4710 4720 4730 4740 4750
SFLYLAWYMT MSVLGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL
4760 4770 4780 4790 4800
VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE DGDTPDMKCD DMLTCYMFHM
4810 4820 4830 4840 4850
YVGVRAGGGI GDEIEDPAGD EYEIYRIIFD ITFFFFVIVI LLAIIQGLII
4860 4870 4880 4890 4900
DAFGELRDQQ EQVKEDMETK CFICGIGNDY FDTVPHGFET HTLQEHNLAN
4910 4920 4930 4940 4950
YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWEFFPAGDC FRKQYEDQLN
Length:4,950
Mass (Da):562,610
Last modified:October 29, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1847F6C7A58F01CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q92736RYR2_HUMAN
Ryanodine receptor 2
RYR2
4,967Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJZ8A0A590UJZ8_HUMAN
Ryanodine receptor 2
RYR2
1,806Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UKB7A0A590UKB7_HUMAN
Ryanodine receptor 2
RYR2
1,327Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJF6A0A590UJF6_HUMAN
Ryanodine receptor 2
RYR2
326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UK06A0A590UK06_HUMAN
Ryanodine receptor 2
RYR2
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL356773 Genomic DNA No translation available.
AL359924 Genomic DNA No translation available.
AL365332 Genomic DNA No translation available.
AL391809 Genomic DNA No translation available.
AL442065 Genomic DNA No translation available.
AL445473 Genomic DNA No translation available.
AL513130 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000360064; ENSP00000353174; ENSG00000198626

UCSC genome browser

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UCSCi
uc057qqo.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356773 Genomic DNA No translation available.
AL359924 Genomic DNA No translation available.
AL365332 Genomic DNA No translation available.
AL391809 Genomic DNA No translation available.
AL442065 Genomic DNA No translation available.
AL445473 Genomic DNA No translation available.
AL513130 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiH7BY35
PRIDEiH7BY35
ProteomicsDBi43489

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3476, 224 antibodies

Genome annotation databases

EnsembliENST00000360064; ENSP00000353174; ENSG00000198626
UCSCiuc057qqo.1, human

Organism-specific databases

HGNCiHGNC:10484, RYR2
OpenTargetsiENSG00000198626
VEuPathDBiHostDB:ENSG00000198626.15

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154906

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RYR2, human

Gene expression databases

BgeeiENSG00000198626, Expressed in heart right ventricle and 162 other tissues
ExpressionAtlasiH7BY35, baseline and differential

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50222, EF_HAND_2, 1 hit
PS50919, MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH7BY35_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H7BY35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: October 29, 2014
Last modified: February 10, 2021
This is version 70 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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