UniProtKB - H7BXG7 (H7BXG7_HUMAN)
Protein
Submitted name:
Protein transport protein Sec31A
Gene
SEC31A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: InterPro
Keywordsi
Biological process | ER-Golgi transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Protein transport protein Sec31AImported |
Gene namesi | Name:SEC31AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138674.16 |
HGNCi | HGNC:17052, SEC31A |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5003608270 | 21 – 969 | Sequence analysisAdd BLAST | 949 |
Proteomic databases
MaxQBi | H7BXG7 |
PeptideAtlasi | H7BXG7 |
PRIDEi | H7BXG7 |
ProteomicsDBi | 43275 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138674, Expressed in pituitary gland and 247 other tissues |
ExpressionAtlasi | H7BXG7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 306 – 499 | Sec16_CInterPro annotationAdd BLAST | 194 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 524 – 555 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 578 – 672 | DisorderedSequence analysisAdd BLAST | 95 | |
Regioni | 688 – 845 | DisorderedSequence analysisAdd BLAST | 158 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 889 – 909 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 578 – 595 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 629 – 645 | Pro-richSequence analysisAdd BLAST | 17 | |
Compositional biasi | 688 – 702 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 731 – 745 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 775 – 805 | PolarSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the WD repeat SEC31 family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00390000003175 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR024298, ACE1_Sec16_Sec31 IPR040251, SEC31-like IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR13923, PTHR13923, 2 hits |
Pfami | View protein in Pfam PF12931, Sec16_C, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 2 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All
H7BXG7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVKLVLLSIV LLKVTVPKLS NDLLQLDFMP IHRGILAIAW SMADPELLLS
60 70 80 90 100
CGKDAKILCS NPNTGEVLYE LPTNTQWCFD IQWCPRNPAV LSAASFDGRI
110 120 130 140 150
SVYSIMGGST DGLRQKQVDK LSSSFGNLDP FGTGQPLPPL QIPQQTAQHS
160 170 180 190 200
IVLPLKKPPK WIRRPVGASF SFGGKLVTFE NVRMPSHQGA EQQQQQHHVF
210 220 230 240 250
ISQVVTEKEF LSRSDQLQQA VQSQGFINYC QKKIDASQTE FEKNVWSFLK
260 270 280 290 300
VNFEDDSRGK YLELLGYRKE DLGKKHIKEE KEESEFLPSS GGTFNISVSG
310 320 330 340 350
DIDGLITQAL LTGNFESAVD LCLHDNRMAD AIILAIAGGQ ELLARTQKKY
360 370 380 390 400
FAKSQSKITR LITAVVMKNW KEIVESCDLK NWREALAAVL TYAKPDEFSA
410 420 430 440 450
LCDLLGTRLE NEGDSLLQTQ ACLCYICAGN VEKLVACWTK AQDGSHPLSL
460 470 480 490 500
QDLIEKVVIL RKAVQLTQAM DTSTVGVLLA AKMSQYANLL AAQGSIAAAL
510 520 530 540 550
AFLPDNTNQP NIMQLRDRLC RAQGEPVAGH ESPKIPYEKQ QLPKGRPGPV
560 570 580 590 600
AGHHQMPRVQ TQQYYPHVRI APTVTTWSNK TPTALPSHPP AASPSDTQGE
610 620 630 640 650
NPPPPGFIMH GNVNPNAAGQ LPTSPGHMHT QVPPYPQPQP YQPAQPYPFG
660 670 680 690 700
TGGSAMYRPQ QPVAPPTSNA YPNTPYISSA SSYTGQSQLY AAQHQASSPT
710 720 730 740 750
SSPATSFPPP PSSGASFQHG GPGAPPSSSA YALPPGTTGP QNGWNDPPAL
760 770 780 790 800
NRVPKKKKMP ENFMPPVPIT SPIMNPLGDP QSQMLQQQPS APVPLSSQSS
810 820 830 840 850
FPQPHLPGGQ PFHGVQQPLG QTGMPPSFSK PNIEGAPGAP IGNTFQHVQS
860 870 880 890 900
LPTKKITKKP IPDEHLILKT TFEDLIQRCL SSATDPQTKR KLDDASKRLE
910 920 930 940 950
FLYDKLREQT LSPTITSGLH NIARSIETRN YSEGLTMHTH IVSTSNFSET
960
SAFMPVLKVV LTQANKLGV
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO94979 | SC31A_HUMAN | Protein transport protein Sec31A | SEC31A KIAA0905, SEC31L1, HSPC275, HSPC334 | 1,220 | Annotation score: | ||
D6REX3 | D6REX3_HUMAN | Protein transport protein Sec31A | SEC31A | 1,251 | Annotation score: | ||
D6RHZ5 | D6RHZ5_HUMAN | Protein transport protein Sec31A | SEC31A | 877 | Annotation score: | ||
H0YAB3 | H0YAB3_HUMAN | Protein transport protein Sec31A | SEC31A | 443 | Annotation score: | ||
H0Y9T9 | H0Y9T9_HUMAN | Protein transport protein Sec31A | SEC31A | 235 | Annotation score: | ||
H0Y8W8 | H0Y8W8_HUMAN | Protein transport protein Sec31A | SEC31A | 383 | Annotation score: | ||
D6RCQ9 | D6RCQ9_HUMAN | Protein transport protein Sec31A | SEC31A | 166 | Annotation score: | ||
D6RE64 | D6RE64_HUMAN | Protein transport protein Sec31A | SEC31A | 164 | Annotation score: | ||
H0Y9V3 | H0Y9V3_HUMAN | Protein transport protein Sec31A | SEC31A | 219 | Annotation score: | ||
H0YAF5 | H0YAF5_HUMAN | Protein transport protein Sec31A | SEC31A | 181 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021105 Genomic DNA No translation available. AC108469 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000264405; ENSP00000264405; ENSG00000138674 |
UCSCi | uc003hne.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021105 Genomic DNA No translation available. AC108469 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | H7BXG7 |
PeptideAtlasi | H7BXG7 |
PRIDEi | H7BXG7 |
ProteomicsDBi | 43275 |
Protocols and materials databases
Antibodypediai | 1692, 135 antibodies |
Genome annotation databases
Ensembli | ENST00000264405; ENSP00000264405; ENSG00000138674 |
UCSCi | uc003hne.4, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138674.16 |
HGNCi | HGNC:17052, SEC31A |
OpenTargetsi | ENSG00000138674 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000003175 |
Miscellaneous databases
ChiTaRSi | SEC31A, human |
Gene expression databases
Bgeei | ENSG00000138674, Expressed in pituitary gland and 247 other tissues |
ExpressionAtlasi | H7BXG7, baseline and differential |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR024298, ACE1_Sec16_Sec31 IPR040251, SEC31-like IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR13923, PTHR13923, 2 hits |
Pfami | View protein in Pfam PF12931, Sec16_C, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 2 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H7BXG7_HUMAN | |
Accessioni | H7BXG7Primary (citable) accession number: H7BXG7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | December 2, 2020 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |