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Entry version 77 (02 Jun 2021)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Adhesion G protein-coupled receptor B2

Gene

Adgrb2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Adhesion G protein-coupled receptor B2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adgrb2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2451244, Adgrb2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation, PhosphoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H7BWZ2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
318644

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028782, Expressed in brain and 177 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H7BWZ2, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H7BWZ2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni757 – 797DisorderedSequence analysisAdd BLAST41
Regioni1355 – 1377DisorderedSequence analysisAdd BLAST23
Regioni1418 – 1447DisorderedSequence analysisAdd BLAST30
Regioni1514 – 1577DisorderedSequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1530 – 1544Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 4 hits
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043838, AGRB_N
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR008077, GPCR_2_brain_angio_inhib
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR000203, GPS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002, 7tm_2, 1 hit
PF19188, AGRB_N, 1 hit
PF16489, GAIN, 1 hit
PF01825, GPS, 1 hit
PF00090, TSP_1, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01694, BAIPRECURSOR
PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00209, TSP1, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895, SSF82895, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50092, TSP1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H7BWZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPACPLLLS VILSLRLATA FDPAPSACSA LASGVLYGAF SLQDLFPTIA
60 70 80 90 100
SGCSWTLENP DPTKYSLYLR FNRQEQVCTH FAPRLLPLDH YLVNFTCLRP
110 120 130 140 150
GPEEATARAE SEVGRPEEEE EEAAAAASGL ELCGGSGPFT FLHFDKNFVQ
160 170 180 190 200
LCLSAEPSEA PRLLAPAALA FRFVEVLLIN NNNSSQFTCG VLCRWSEECG
210 220 230 240 250
RAAGRACGFA QPGCSCPGEA GANPATTTSP GPPVAHTLSN ALVPGGPAPP
260 270 280 290 300
AEADLHSGSS NDLFTTEMRY GEEPEEEPKV KTQWPRSADE PGLYMAQTGD
310 320 330 340 350
PAAEEWSPWS VCSLTCGQGL QVRTRSCVSS PYGTLCSGPL RETRPCNNSA
360 370 380 390 400
TCPVHGVWEE WGSWSLCSRS CGRGSRSRMR TCVPPQHGGK ACEGPELQTK
410 420 430 440 450
LCSMAACPVE GQWLEWGPWG PCSSSCANGT QQRSRKCSVA GPAWATCAGA
460 470 480 490 500
LTDTRECSNL DCPATDGKWG PWNAWSLCSK TCDTGWQRRF RMCQASGTQG
510 520 530 540 550
YPCEGTGEEV KPCSEKRCPA FHEMCRDEYV MLMTWKRAAA GEIIYNKCPP
560 570 580 590 600
NASGSASRRC LLSAQGVAYW GLPSFARCIS HEYRYLYLSL REHLAKGQRM
610 620 630 640 650
LAGEGMSQVV RSLQELLARR TYYSGDLLFS VDILRNVTDT FKRATYVPSA
660 670 680 690 700
DDVQRFFQVV SFMVDSENKD KWDDAQQVSP GSVHLLRVVE DFIHLVGDAL
710 720 730 740 750
KAFQSSLIVT DNLVISIQRE PISAVSSDIT FPMRGRRGMK DWVRHSEDRL
760 770 780 790 800
FLPKEVLSLS SPGKPATPGA ATAGSPGRGR GPGTVPPGPG HAHQRLLPAD
810 820 830 840 850
PEESSSYFVI GAVLYRTLGL ILPPPRPPLA VTSRVMTVTV RPPTQPPAEP
860 870 880 890 900
LITVELSYII NGTTDPHCAS WDYSRADTNS GDWNTESCQT LETQAAHTRC
910 920 930 940 950
QCQHLSTFAV LAQPPKDLTL ELAGAPSVPL VIGCAVSCMA LLTLLAIYAA
960 970 980 990 1000
FWRFIKSERS IILLNFCLSI LASNILILVG QSRVLSKGVC TMTAAFLHFF
1010 1020 1030 1040 1050
FLSSFCWVLT EAWQSYLAVI GRMRTRLVRK RFLCLGWGLP ALVVAVSVGF
1060 1070 1080 1090 1100
TRTKGYGTSS YCWLSLEGGL LYAFVGPAAV IVLVNMLIGI IVFNKLMARD
1110 1120 1130 1140 1150
GVSDKSKKQR AGSERCPWAS LLLPCSACGA VPSPLLSSAS ARNAMASLWS
1160 1170 1180 1190 1200
SCVVLPLLAL TWMSAVLAMT DRRSVLFQAL FAVFNSAQGF VITAVHCFLR
1210 1220 1230 1240 1250
REVQDVVKCQ MGVCRADESE DSPDSCKNGQ LQILSDFEKD VDLACQTVLF
1260 1270 1280 1290 1300
KEVNTCNPST ITGTLSRLSL DEDEEPKSCL VGPEGGLSFS PLPGNILVPM
1310 1320 1330 1340 1350
AASPGLGEPP PPQETNPVYM CGEGGLRQLD LTWIRQSEPG SEGDYMVLPR
1360 1370 1380 1390 1400
RTLSLQPGGG GTAGEEAPRA RPEGTPRRAA KTVAHTEGYP SFLSVEHSGL
1410 1420 1430 1440 1450
GLGPAYGSLQ NPYGMTFQPP PPTPSARQVP EPGERSRTMP RTVPGSTMKL
1460 1470 1480 1490 1500
GSLERKKLRY SDLDFEKVMH TRKRHSELYH ELNQKFHTFD RYRSQSSAKV
1510 1520 1530 1540 1550
RWMRGCNRLA LLLSQEKPSP PGGRPGLSQH RRHQSWSTFK SMTLGSLPPK
1560 1570
PRERLALHRT AAWEPTEPPD GDFQTEV
Length:1,577
Mass (Da):171,761
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB387101E434C364F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CGM1AGRB2_MOUSE
Adhesion G protein-coupled receptor...
Adgrb2 Bai2
1,561Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ASC0B1ASC0_MOUSE
Adhesion G protein-coupled receptor...
Adgrb2
1,473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BX74H7BX74_MOUSE
Adhesion G protein-coupled receptor...
Adgrb2
1,544Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BX92H7BX92_MOUSE
Adhesion G protein-coupled receptor...
Adgrb2
1,489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000030571; ENSMUSP00000030571; ENSMUSG00000028782

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiH7BWZ2
ModBaseiSearch...

Proteomic databases

MaxQBiH7BWZ2
ProteomicsDBi318644

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
16794, 279 antibodies

Genome annotation databases

EnsembliENSMUST00000030571; ENSMUSP00000030571; ENSMUSG00000028782

Organism-specific databases

MGIiMGI:2451244, Adgrb2

Phylogenomic databases

GeneTreeiENSGT00940000160103

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Adgrb2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028782, Expressed in brain and 177 other tissues
ExpressionAtlasiH7BWZ2, baseline and differential

Family and domain databases

Gene3Di2.20.100.10, 4 hits
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR043838, AGRB_N
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR008077, GPCR_2_brain_angio_inhib
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR000203, GPS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF19188, AGRB_N, 1 hit
PF16489, GAIN, 1 hit
PF01825, GPS, 1 hit
PF00090, TSP_1, 4 hits
PRINTSiPR01694, BAIPRECURSOR
PR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00209, TSP1, 4 hits
SUPFAMiSSF82895, SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50092, TSP1, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH7BWZ2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H7BWZ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 2, 2021
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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