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UniProtKB - H7BWY6 (H7BWY6_MOUSE)
Protein
Plasma retinol-binding protein
Gene
Rbp4
Organism
Mus musculus (Mouse)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 160 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- retinal binding Source: UniProtKB-KW
- retinol binding Source: UniProtKB-KW
- retinol transmembrane transporter activity Source: InterPro
GO - Biological processi
- eye development Source: Ensembl
- gluconeogenesis Source: Ensembl
- glucose homeostasis Source: Ensembl
- maintenance of gastrointestinal epithelium Source: Ensembl
- positive regulation of insulin secretion Source: Ensembl
- response to retinoic acid Source: Ensembl
- retinol metabolic process Source: Ensembl
Keywordsi
Ligand | Retinol-bindingARBA annotation, Vitamin AARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Plasma retinol-binding proteinARBA annotationAlternative name(s): Retinol-binding protein 4ARBA annotation |
Gene namesi | Name:Rbp4Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97879, Rbp4 |
VEuPathDBi | HostDB:ENSMUSG00000024990 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular space Source: Ensembl
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 66 ↔ 222 | UniRule annotation | ||
Disulfide bondi | 132 ↔ 236 | UniRule annotation | ||
Disulfide bondi | 182 ↔ 191 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationProteomic databases
jPOSTi | H7BWY6 |
MaxQBi | H7BWY6 |
PeptideAtlasi | H7BWY6 |
PRIDEi | H7BWY6 |
ProteomicsDBi | 355233 |
PTM databases
SwissPalmi | H7BWY6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024990, Expressed in liver and 241 other tissues |
ExpressionAtlasi | H7BWY6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 83 – 215 | Lipocln_cytosolic_FA-bd_domInterPro annotationAdd BLAST | 133 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00510000047107 |
OrthoDBi | 1631943at2759 |
PhylomeDBi | H7BWY6 |
TreeFami | TF331445 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR022271, Lipocalin_ApoD IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom IPR002449, Retinol-bd/Purpurin |
PANTHERi | PTHR11873, PTHR11873, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PIRSFi | PIRSF036893, Lipocalin_ApoD, 1 hit PIRSF500204, RBP_purpurin, 1 hit |
PRINTSi | PR01174, RETINOLBNDNG |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
H7BWY6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPLGWRVWL HRDHPERSSE HRRRGTARLT EGPRVRSGGR LRGEMEWVWA
60 70 80 90 100
LVLLAALGGG SAERDCRVSS FRVKENFDKA RFSGLWYAIA KKDPEGLFLQ
110 120 130 140 150
DNIIAEFSVD EKGHMSATAK GRVRLLSNWE VCADMVGTFT DTEDPAKFKM
160 170 180 190 200
KYWGVASFLQ RGNDDHWIID TDYDTFALQY SCRLQNLDGT CADSYSFVFS
210 220 230 240
RDPNGLSPET RRLVRQRQEE LCLERQYRWI EHNGYCQSRP SRNSL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ00724 | RET4_MOUSE | Retinol-binding protein 4 | Rbp4 | 201 | Annotation score: | ||
A0A494B9P3 | A0A494B9P3_MOUSE | Plasma retinol-binding protein | Rbp4 | 104 | Annotation score: | ||
A0A494B9T2 | A0A494B9T2_MOUSE | Retinol-binding protein 4 | Rbp4 | 122 | Annotation score: |
Sequence databases
RefSeqi | NP_001152959.1, NM_001159487.1 |
Genome annotation databases
Ensembli | ENSMUST00000025951; ENSMUSP00000025951; ENSMUSG00000024990 |
GeneIDi | 19662 |
UCSCi | uc008hje.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001152959.1, NM_001159487.1 |
3D structure databases
SMRi | H7BWY6 |
ModBasei | Search... |
PTM databases
SwissPalmi | H7BWY6 |
Proteomic databases
jPOSTi | H7BWY6 |
MaxQBi | H7BWY6 |
PeptideAtlasi | H7BWY6 |
PRIDEi | H7BWY6 |
ProteomicsDBi | 355233 |
Protocols and materials databases
Antibodypediai | 885, 1420 antibodies from 45 providers |
DNASUi | 19662 |
Genome annotation databases
Ensembli | ENSMUST00000025951; ENSMUSP00000025951; ENSMUSG00000024990 |
GeneIDi | 19662 |
UCSCi | uc008hje.2, mouse |
Organism-specific databases
CTDi | 5950 |
MGIi | MGI:97879, Rbp4 |
VEuPathDBi | HostDB:ENSMUSG00000024990 |
Phylogenomic databases
GeneTreei | ENSGT00510000047107 |
OrthoDBi | 1631943at2759 |
PhylomeDBi | H7BWY6 |
TreeFami | TF331445 |
Miscellaneous databases
BioGRID-ORCSi | 19662, 0 hits in 65 CRISPR screens |
ChiTaRSi | Rbp4, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024990, Expressed in liver and 241 other tissues |
ExpressionAtlasi | H7BWY6, baseline and differential |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR022271, Lipocalin_ApoD IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom IPR002449, Retinol-bd/Purpurin |
PANTHERi | PTHR11873, PTHR11873, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PIRSFi | PIRSF036893, Lipocalin_ApoD, 1 hit PIRSF500204, RBP_purpurin, 1 hit |
PRINTSi | PR01174, RETINOLBNDNG |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H7BWY6_MOUSE | |
Accessioni | H7BWY6Primary (citable) accession number: H7BWY6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | January 19, 2022 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |