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Entry version 48 (02 Dec 2020)
Sequence version 1 (18 Apr 2012)
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Protein

Na(+)-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B

Gene

rnfB

Organism
Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Couples electron transfer from reduced ferredoxin to NAD+ with electrogenic movement of Na+ out of the cell. Involved in caffeate respiration.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 7 [4Fe-4S] clusters.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi50Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi53Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi58Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi75Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi138Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi142Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi148Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi152Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi172Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi175Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi178Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi182Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi217Iron-sulfur 4 (4Fe-4S)UniRule annotation1
Metal bindingi220Iron-sulfur 4 (4Fe-4S)UniRule annotation1
Metal bindingi223Iron-sulfur 4 (4Fe-4S)UniRule annotation1
Metal bindingi227Iron-sulfur 4 (4Fe-4S)UniRule annotation1
Metal bindingi246Iron-sulfur 5 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi249Iron-sulfur 5 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi252Iron-sulfur 5 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi256Iron-sulfur 5 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi279Iron-sulfur 6 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi282Iron-sulfur 6 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi285Iron-sulfur 6 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi289Iron-sulfur 6 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi310Iron-sulfur 7 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi313Iron-sulfur 7 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi316Iron-sulfur 7 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi320Iron-sulfur 7 (4Fe-4S)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
AWOO931626:G1H37-2276-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.D.6.1.2, the ion (h(+) or na(+))-translocating nadh:ferredoxin oxidoreductase (nfo or rnf) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Na(+)-translocating ferredoxin:NAD(+) oxidoreductase complex subunit BCurated (EC:7.2.1.22 Publications)
Alternative name(s):
Rnf electron transport complex subunit BUniRule annotationCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rnfB1 PublicationUniRule annotation
Ordered Locus Names:Awo_c22010Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri931626 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeAcetobacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007177 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004435171 – 333Na(+)-translocating ferredoxin:NAD(+) oxidoreductase complex subunit BAdd BLAST333

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

UniRule annotation1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
931626.Awo_c22010

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H6LC27

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 924Fe-4SUniRule annotationAdd BLAST60
Domaini126 – 1624Fe-4S ferredoxin-type 1UniRule annotationAdd BLAST37
Domaini163 – 1924Fe-4S ferredoxin-type 2UniRule annotationAdd BLAST30
Domaini207 – 2374Fe-4S ferredoxin-type 3UniRule annotationAdd BLAST31
Domaini239 – 2664Fe-4S ferredoxin-type 4UniRule annotationAdd BLAST28
Domaini270 – 2994Fe-4S ferredoxin-type 5UniRule annotationAdd BLAST30
Domaini301 – 3304Fe-4S ferredoxin-type 6UniRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27HydrophobicUniRule annotationAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1245, Bacteria
COG2878, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_053470_0_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
MLPGANC

Database of Orthologous Groups

More...
OrthoDBi
1619561at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.20, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00463, RsxB_RnfB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007202, 4Fe-4S_dom
IPR017896, 4Fe4S_Fe-S-bd
IPR017900, 4Fe4S_Fe_S_CS
IPR011005, Dihydropteroate_synth-like
IPR010207, Elect_transpt_cplx_RnfB/RsxB

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00037, Fer4, 3 hits
PF13187, Fer4_9, 1 hit
PF04060, FeS, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51656, 4FE4S, 1 hit
PS00198, 4FE4S_FER_1, 3 hits
PS51379, 4FE4S_FER_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H6LC27-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNAILVPVG ILGVFGLIFG IGLAIAAKVF EVYEDPRVPL VRAALPGANC
60 70 80 90 100
GGCGLPGCDA LAANIVGGSA AIDACPVGGA SCAAAVAEIM GMEAGSAVKK
110 120 130 140 150
VATVICQGTC ETAPNRAEYY GEMDCREAMI ASGGSKGCRY GCLGYGTCKA
160 170 180 190 200
VCPFDAIVIG EDGLPKVDPE KCTSCGKCVE ACPKSIMTLV PEAQEVIVKC
210 220 230 240 250
HNFDKGKIAR LSCTTACIAC GACVKACRFD AITVENNCAK IDYDKCRQCY
260 270 280 290 300
ECVDKCPMNC ISGDVEYGKS TAYIIEENCI ACGLCAKNCP VNAITGEIKK
310 320 330
PPYVIDHDMC IGCGICFDKC RKSAIEMRPN KTK
Length:333
Mass (Da):34,727
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i138977C70B402B87
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ416148 Genomic DNA Translation: ACR23747.1
CP002987 Genomic DNA Translation: AFA48975.1

NCBI Reference Sequences

More...
RefSeqi
WP_014356575.1, NC_016894.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AFA48975; AFA48975; Awo_c22010

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
awo:Awo_c22010

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ416148 Genomic DNA Translation: ACR23747.1
CP002987 Genomic DNA Translation: AFA48975.1
RefSeqiWP_014356575.1, NC_016894.1

3D structure databases

SMRiH6LC27
ModBaseiSearch...

Protein-protein interaction databases

STRINGi931626.Awo_c22010

Protein family/group databases

TCDBi3.D.6.1.2, the ion (h(+) or na(+))-translocating nadh:ferredoxin oxidoreductase (nfo or rnf) family

Genome annotation databases

EnsemblBacteriaiAFA48975; AFA48975; Awo_c22010
KEGGiawo:Awo_c22010

Phylogenomic databases

eggNOGiCOG1245, Bacteria
COG2878, Bacteria
HOGENOMiCLU_053470_0_0_9
OMAiMLPGANC
OrthoDBi1619561at2

Enzyme and pathway databases

BioCyciAWOO931626:G1H37-2276-MONOMER

Family and domain databases

Gene3Di3.20.20.20, 1 hit
HAMAPiMF_00463, RsxB_RnfB, 1 hit
InterProiView protein in InterPro
IPR007202, 4Fe-4S_dom
IPR017896, 4Fe4S_Fe-S-bd
IPR017900, 4Fe4S_Fe_S_CS
IPR011005, Dihydropteroate_synth-like
IPR010207, Elect_transpt_cplx_RnfB/RsxB
PfamiView protein in Pfam
PF00037, Fer4, 3 hits
PF13187, Fer4_9, 1 hit
PF04060, FeS, 1 hit
PROSITEiView protein in PROSITE
PS51656, 4FE4S, 1 hit
PS00198, 4FE4S_FER_1, 3 hits
PS51379, 4FE4S_FER_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNFB_ACEWD
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H6LC27
Secondary accession number(s): C4N8U5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2018
Last sequence update: April 18, 2012
Last modified: December 2, 2020
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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