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Entry version 42 (18 Sep 2019)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

FI19304p1

Gene

LIMK1-RD

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FI19304p1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIMK1-RDImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
H5V8E7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0041203 Expressed in 26 organ(s), highest expression level in wing disc (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H5V8E7 differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
H5V8E7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 69PDZInterPro annotationAdd BLAST69
Domaini196 – 481Protein kinaseInterPro annotationAdd BLAST286

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni347 – 382DisorderedSequence analysisAdd BLAST36
Regioni554 – 606DisorderedSequence analysisAdd BLAST53
Regioni676 – 695DisorderedSequence analysisAdd BLAST20
Regioni805 – 832DisorderedSequence analysisAdd BLAST28
Regioni880 – 977DisorderedSequence analysisAdd BLAST98
Regioni1007 – 1052DisorderedSequence analysisAdd BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili698 – 718Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi355 – 374PolarSequence analysisAdd BLAST20
Compositional biasi565 – 606PolyampholyteSequence analysisAdd BLAST42
Compositional biasi814 – 832PolarSequence analysisAdd BLAST19
Compositional biasi880 – 895PolarSequence analysisAdd BLAST16
Compositional biasi902 – 970PolarSequence analysisAdd BLAST69
Compositional biasi1016 – 1030PolarSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEZ9 Eukaryota
COG0515 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 1 hit
PF00069 Pkinase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H5V8E7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFWLHFVLK KILPWLKSTK IDVNLTNLHI GDRILEVNGT PVSDSSVEQI
60 70 80 90 100
DKLIRSNEKM LQLTVEHDPV QVCRSCSQAD IQRAMSASTL ILPLSTSASS
110 120 130 140 150
VEVGRERLYK TPGEQGTKAR KLRQATNAST TIPPAAGATA MTQLKEKERC
160 170 180 190 200
SSLSKLLDEQ HQAQQHSAHP QLYDLSRTQS CRVVQKPQRI FRATDLVIGE
210 220 230 240 250
KLGEGFFGKV FKVTHRQSGE VMVLKELHRA DEEAQRNFIK EVAVLRLLDH
260 270 280 290 300
RHVLKFIGVL YKDKKLHMVT EYVAGGCLKE LIHDPAQVLP WPQRVRLARD
310 320 330 340 350
IACGMSYLHS MNIIHRDLNS MNCLVREDRS VIVADFGLAR SVDAPRLPSG
360 370 380 390 400
NMTPGGYGSG ANSDAPMSPS GTLRRSKSRQ RRQRYTVVGN PYWMAPEMMK
410 420 430 440 450
GLKYDEKVDV FSFGIMLCEI IGRVEADPDF MPRNSDFSLN QQEFREKFCA
460 470 480 490 500
QCPEPFVKVA FVCCDLNPDM RPCFETLHVW LQRLADDLAA DRVPPERLLH
510 520 530 540 550
EIETFQEWYA SSEDALSPTS QRSLNNLDEL VKSAVDSEIS PVEKEKENMV
560 570 580 590 600
IKPQDIPKSP HLGKDFSPSG ERLRDSMRAR RRQRFLGAQE ERRNLTPDTE
610 620 630 640 650
SKERALKKAL KKCRPFGERG YLVDLRAGAE LQLEDVRDLN TYSDVDSSCD
660 670 680 690 700
TSLNYHDVNN LPAAQEDENT VKPGKEELLE ESTNKPSNQE SQHHRLAIDD
710 720 730 740 750
MRTRLNQCRS KFEHLEEASR RNFNQSQHSM KNFFKTPPVA LKMFQRLEHE
760 770 780 790 800
AAALNGGNNC PPPPPRTQRI NQTPIFGRKN PPVAIVGQKL QHAESLEDLA
810 820 830 840 850
SSGVAKQLAT PAPKRSKATA TTKGGQSSNP PLFLPPSLNI SVALNSNGNV
860 870 880 890 900
TTTTNTNSSC PPSASDWLPK KHKLTLPLPS AQQQRTSSNH RLPMCNNKGK
910 920 930 940 950
TLKPLPSRTG SQGIPASNCV SPTRSSRPGS PTKHLAQRHT AATAQRLTNA
960 970 980 990 1000
AATHQQQHQQ QSSKTTRLNI LSPEKVHRLG ARLTDQKQKM REEAAATASS
1010 1020 1030 1040 1050
VGGAGCAAGT AAGSLNGHRT IGSSGTPNSA VGERRRRAAP SPPVRTHFNT

RC
Length:1,052
Mass (Da):117,137
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82DF96FEAFDCDD1C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BT133248 mRNA Translation: AFB40593.1

NCBI Reference Sequences

More...
RefSeqi
NP_727622.1, NM_167327.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32207

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT133248 mRNA Translation: AFB40593.1
RefSeqiNP_727622.1, NM_167327.2

3D structure databases

SMRiH5V8E7
ModBaseiSearch...

Proteomic databases

PRIDEiH5V8E7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi32207

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3984

Phylogenomic databases

eggNOGiENOG410IEZ9 Eukaryota
COG0515 LUCA

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32207

Gene expression databases

BgeeiFBgn0041203 Expressed in 26 organ(s), highest expression level in wing disc (Drosophila)
ExpressionAtlasiH5V8E7 differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00069 Pkinase, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH5V8E7_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H5V8E7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 18, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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