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Entry version 38 (07 Oct 2020)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

AF4/FMR2 family, member 4

Gene
N/A
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AF4/FMR2 family, member 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini873 – 1134AF-4_CInterPro annotationAdd BLAST262

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 294DisorderedSequence analysisAdd BLAST294
Regioni306 – 661DisorderedSequence analysisAdd BLAST356
Regioni697 – 877DisorderedSequence analysisAdd BLAST181
Regioni1007 – 1031DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili889 – 913Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 21PolyampholyteSequence analysisAdd BLAST21
Compositional biasi71 – 87PolarSequence analysisAdd BLAST17
Compositional biasi98 – 136PolarSequence analysisAdd BLAST39
Compositional biasi138 – 156PolyampholyteSequence analysisAdd BLAST19
Compositional biasi157 – 178PolarSequence analysisAdd BLAST22
Compositional biasi179 – 202PolyampholyteSequence analysisAdd BLAST24
Compositional biasi203 – 223PolarSequence analysisAdd BLAST21
Compositional biasi247 – 273PolarSequence analysisAdd BLAST27
Compositional biasi339 – 354PolarSequence analysisAdd BLAST16
Compositional biasi355 – 377PolyampholyteSequence analysisAdd BLAST23
Compositional biasi378 – 402PolarSequence analysisAdd BLAST25
Compositional biasi409 – 426PolarSequence analysisAdd BLAST18
Compositional biasi456 – 472PolarSequence analysisAdd BLAST17
Compositional biasi487 – 508PolarSequence analysisAdd BLAST22
Compositional biasi545 – 562PolyampholyteSequence analysisAdd BLAST18
Compositional biasi610 – 630PolyampholyteSequence analysisAdd BLAST21
Compositional biasi631 – 653PolarSequence analysisAdd BLAST23
Compositional biasi707 – 784PolyampholyteSequence analysisAdd BLAST78
Compositional biasi807 – 830PolarSequence analysisAdd BLAST24
Compositional biasi831 – 857PolyampholyteSequence analysisAdd BLAST27
Compositional biasi858 – 876PolarSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006484_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3DLG9

Identification of Orthologs from Complete Genome Data

More...
OMAi
SYSADHY

TreeFam database of animal gene trees

More...
TreeFami
TF326216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043640, AF4/FMR2_C
IPR043639, AF4_int
IPR007797, TF_AF4/FMR2

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H3DLG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNREDRNVLR MKERERRNQE IQQGGEAFPA NSPLFPEPYK VSSKEDKLSS
60 70 80 90 100
RIQSMLGNYD EMKDSFGDTH PKISTKPSNS SSSSEEKLGP PLFVGDQRGI
110 120 130 140 150
SSSGSSQSNK CTPLGPAASG SASQSQKRSA LGSQSQRHGG EVREKKSSKH
160 170 180 190 200
SGSSEHSKSH TSSPAKGSLS SYLRSSLSAE QHHNKERYRS KSPREREPNW
210 220 230 240 250
DSPSRVHTSF PSGQHSSQAF PPSLMSKPGP MLQKPTAYVR PMDGQETAEP
260 270 280 290 300
KSSQAESYSG QSHSSTMGEM KSNGKASLSK LKIPSQPVEG SGDANCVDEI
310 320 330 340 350
LKEMTQSWPP PLTAIHTPCK TEPSKFPFPT KDSHPFPSGH TERASSSKSS
360 370 380 390 400
SSHQPKTVLE DDLKLSSSED SDGEQDSAKN ASRNTSQALP HTNSNNSEGA
410 420 430 440 450
EQSRDDSSSH SGSESSSGSD SESESSTTDS ETNEHQRPAS PEPEQPMANK
460 470 480 490 500
WQLDNWFRAK TKQLSPASPV DSNVPTKCKK EGRENSSGRG YGSQGGGSKD
510 520 530 540 550
STAPTPNRDL RAAQKGPEGG RGRQKSPAQS EGGPNPRRSV GKKQPKKSEK
560 570 580 590 600
PPVVEEPKGG LRVESEPAPQ IPPHRPKAAT KGSRKPSVKK EPKSSPRPAP
610 620 630 640 650
AAVTSNADKR KPKAPTKTSQ KSREFVKTDS SSSDSEGNDS IPSSSQTPKY
660 670 680 690 700
TESIRTPVCV FSPMDEKELL SPLSDPEERY PARQLQQQVL LVKIDLNLLS
710 720 730 740 750
RIPGRPYKDP VEIKVERDDS LDRDGKDCSK PISEKSSSKA KRKHKNDEEG
760 770 780 790 800
SKPGSKRCKL EEKSLSHHKS SSKESKRSLE KKEEPVPSPS LSGLQRTPKV
810 820 830 840 850
EHPSRKRTVS QSSTSLSSGT GSGKEGNHSA KSNSTSKHRK GEDKGRSTRD
860 870 880 890 900
GKEKSSKSCD NQLAVPPLST DGSKSQRSKL VFEDRVHSAD HYLQEAKKLK
910 920 930 940 950
HNADALLDRF EKAVYYLDAV VSFIECGNAL EKSAQEAKSP FPMYAETVEL
960 970 980 990 1000
IKYTMKLKSY MAPDATSADK RLAVLCLRCQ SLLYLRLFKL RKDSALKYSK
1010 1020 1030 1040 1050
TLTEHLKNSL SNTQAPSPGM GNKAAGMPSP VSPKLSPGTA VGYSSVSSSS
1060 1070 1080 1090 1100
SASSSVTIPQ RIHQMAASYV QVTSNFLYAT EVWDQAEQLS KEQKDFFSEL
1110 1120 1130
DKVMGPLIFN TSSMTELVRY TRQGLHWLRL DAKLIP
Length:1,136
Mass (Da):123,971
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D90E6A83B8A05A0
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000021602; ENSTNIP00000021367; ENSTNIG00000018201

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTNIT00000021602; ENSTNIP00000021367; ENSTNIG00000018201

Phylogenomic databases

GeneTreeiENSGT00950000182974
HOGENOMiCLU_006484_0_0_1
InParanoidiH3DLG9
OMAiSYSADHY
TreeFamiTF326216

Family and domain databases

InterProiView protein in InterPro
IPR043640, AF4/FMR2_C
IPR043639, AF4_int
IPR007797, TF_AF4/FMR2
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3DLG9_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3DLG9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: October 7, 2020
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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