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Entry version 57 (02 Jun 2021)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Ankyrin 2a, neuronal

Gene
N/A
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin 2a, neuronalImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 791ANK_REP_REGIONInterPro annotationAdd BLAST784
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 73ANKPROSITE-ProRule annotationAdd BLAST33
Repeati74 – 106ANKPROSITE-ProRule annotationAdd BLAST33
Repeati107 – 139ANKPROSITE-ProRule annotationAdd BLAST33
Repeati140 – 163ANKPROSITE-ProRule annotationAdd BLAST24
Repeati210 – 242ANKPROSITE-ProRule annotationAdd BLAST33
Repeati243 – 275ANKPROSITE-ProRule annotationAdd BLAST33
Repeati276 – 308ANKPROSITE-ProRule annotationAdd BLAST33
Repeati309 – 341ANKPROSITE-ProRule annotationAdd BLAST33
Repeati342 – 374ANKPROSITE-ProRule annotationAdd BLAST33
Repeati375 – 407ANKPROSITE-ProRule annotationAdd BLAST33
Repeati408 – 440ANKPROSITE-ProRule annotationAdd BLAST33
Repeati441 – 473ANKPROSITE-ProRule annotationAdd BLAST33
Repeati474 – 506ANKPROSITE-ProRule annotationAdd BLAST33
Repeati507 – 539ANKPROSITE-ProRule annotationAdd BLAST33
Repeati540 – 572ANKPROSITE-ProRule annotationAdd BLAST33
Repeati573 – 605ANKPROSITE-ProRule annotationAdd BLAST33
Repeati606 – 638ANKPROSITE-ProRule annotationAdd BLAST33
Repeati639 – 671ANKPROSITE-ProRule annotationAdd BLAST33
Repeati672 – 704ANKPROSITE-ProRule annotationAdd BLAST33
Repeati705 – 737ANKPROSITE-ProRule annotationAdd BLAST33
Repeati738 – 770ANKPROSITE-ProRule annotationAdd BLAST33
Domaini953 – 1141ZU5InterPro annotationAdd BLAST189
Domaini1143 – 1291ZU5InterPro annotationAdd BLAST149
Domaini1471 – 1555DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1220 – 1239DisorderedSequence analysisAdd BLAST20
Regioni1443 – 1472DisorderedSequence analysisAdd BLAST30
Regioni1586 – 1613DisorderedSequence analysisAdd BLAST28
Regioni1632 – 1774DisorderedSequence analysisAdd BLAST143

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1223 – 1239Polar residuesSequence analysisAdd BLAST17
Compositional biasi1445 – 1472Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi1597 – 1612Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1632 – 1652Polar residuesSequence analysisAdd BLAST21
Compositional biasi1661 – 1693Polar residuesSequence analysisAdd BLAST33
Compositional biasi1729 – 1754Basic and acidic residuesSequence analysisAdd BLAST26

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000134_7_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3DKB8

Identification of Orthologs from Complete Genome Data

More...
OMAi
PAKNGHT

TreeFam database of animal gene trees

More...
TreeFami
TF351263

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 7 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 21 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H3DKB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RSSHLQSDSN TSFLRAARAG NIDKVLDFLK NGIDISTCNQ NGLNALHLAA
60 70 80 90 100
KEGHKDLVEE LLDRGAPVDS STKKGNSALH IASLAGQKEV VRLLVKRGAN
110 120 130 140 150
INSQSQNGFT PLYMAAQENH LEVVRYLLEN DGNQSIATED GFTPLAIALQ
160 170 180 190 200
QGHNSVVSLL LEHDTKGKVR LPALHIAARK DDTKSAALLL QNDHNADVQS
210 220 230 240 250
KMMVNRTTES GFTPLHIAAH YGNVNVSTLL LNRGAAVDFT ARNGITPLHV
260 270 280 290 300
ASKRGNTNMV ALLLDRGAQI DAKTRDGLTP LHCAARSGHD QAVEILLDRG
310 320 330 340 350
APILARTKNG LSPLHMSAQG DHIECVKLLL QHQAPVDDVT LDYLTALHVA
360 370 380 390 400
AHCGHYRVTK LLLDKKANPN VRALNGFTPL HIACKKNRVK VMELLVKYGA
410 420 430 440 450
SIQAITESGL TPIHVAAFMG HLSIVLLLLQ NGASPDIRNI RGETALHMAA
460 470 480 490 500
RAGQMEVVRC LLRNGALVDA MAREDQTPLH IASRLGKTDI VQLLLQHMAH
510 520 530 540 550
PDAATTNGYT PLHISAREGQ LETAAVLLEA GASHSLPTKK GFTPLHVAAK
560 570 580 590 600
YGNLDVAKLL LQSKALPDDA GKNGLTSLHV AAHYDNQDVA LLLLDKGASP
610 620 630 640 650
HSTAKNGYTP LHIAAKKNQT KIASALLQYG AETNILTKQG VSPLHLAAQE
660 670 680 690 700
GHTEMTGLLL DKGAHVNAAT KSGLTPLHLT AQEDKVGAAE VLAKYDANLD
710 720 730 740 750
QQTKLGYTPL IVACHYGNAK MVNFLLQQGA SVNAKTKNGY TPLHQAAQQG
760 770 780 790 800
NTHIINVLLQ HGAKPNTTTM SGNTALSIAR RLGYISVVDT LKVVTEEVIT
810 820 830 840 850
TTTTVTEKHK LNVPETMTEV LDVSDEEGED TMTGDGGEYL RAEDLRDLGD
860 870 880 890 900
DSLPGHYLDF SYMNNMNIDR WKSDKQTNKS QHTPIHQSFT QREGFFIEDM
910 920 930 940 950
LTSHQVSVLS KEHEKDSFRL SWGAEHLDNV VLSSSLLHSG RSTPCLDHDN
960 970 980 990 1000
SSFLVSFMVD ARGGAMRGCR HNGLRIIVPP RKCSAPTRVT CRLVKRHRLA
1010 1020 1030 1040 1050
SMPPMVEGEG LAGRIIEVGP TGAQFLGKLH LPTAPPPLNE GESLVSRILQ
1060 1070 1080 1090 1100
LGPPGTKFLG PVIVEIPHFA ALRGTERELV ILRSETGESW REHHCDFTEE
1110 1120 1130 1140 1150
ELNQILNGMD EKLDSPEELE KKRICRIITR DFPQYFAVVS RIKQDSHLIG
1160 1170 1180 1190 1200
PEGGVLSSTL VPQVQAVFPE GALTKKIRVG LQAQPIDGDV VKKILGNKAA
1210 1220 1230 1240 1250
FSAIVTLEPR RRKFHKPITM TIPIPKSPNT EGPTSEFSGE TPTLRLLCSI
1260 1270 1280 1290 1300
TGGTTPAQWE DITGSTPLTF VNHCVSFTTN VSARFWLIDC RQVQESVSFA
1310 1320 1330 1340 1350
SQLYREIICV PYMAKFVIFA KTLDPIEARL RCFCMTDDKM DKTLEQQENF
1360 1370 1380 1390 1400
TEVARSRDVE VLEGKPIFVD CFGNLVPLTK SGQHHVFSFF AFKENRLALF
1410 1420 1430 1440 1450
IKIRDTAQEP CGRLSFTKEA RTYRSLTHNA ICNLNITLPA YSKESDSDQD
1460 1470 1480 1490 1500
GDDEKPLTSE SRSTDSQEES KEETLTIIAD LLGFSWTELA KELEFSENDI
1510 1520 1530 1540 1550
QSVRTDNPNS LQEQSHALLQ RWVEREGKHA TEDCLIKTLT KINRMDIVHL
1560 1570 1580 1590 1600
IETQMNKSVQ EQTSRTYAEI EKTLDHSEDV EKVDRTLCLP EPKQSSQIAE
1610 1620 1630 1640 1650
SREKDFFDHP RPESPHFASI SFSLSPDHFR VSESTDSTGV LSPRSQIKDD
1660 1670 1680 1690 1700
TPRTGSLGKC KDTPHASTTA PKTNQSQSIT QKAVSSTQAE GFLGPESPQR
1710 1720 1730 1740 1750
LREVVEPSQN SEVYFESGEP ESEEYEDAPF VQEPLRPGHE DSEERARSSE
1760 1770 1780 1790 1800
PSDDEFTLCE ASQPPAACSA GDRTDNCLPR ADDFPEFATQ SVTEEKYRDE
1810 1820 1830 1840 1850
NGHIVVKKIT RKIIRKCVSA EADREEVSFE GDAFAAQEEG GYPKVVKRTV
1860
LKSEGGHTES SNL
Length:1,863
Mass (Da):204,721
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i236CF14AAE54B759
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3DKB5H3DKB5_TETNG
Ankyrin 2a, neuronal
1,540Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3DKB6H3DKB6_TETNG
Ankyrin 2a, neuronal
1,541Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000021197; ENSTNIP00000020964; ENSTNIG00000017807

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTNIT00000021197; ENSTNIP00000020964; ENSTNIG00000017807

Phylogenomic databases

GeneTreeiENSGT00940000155279
HOGENOMiCLU_000134_7_2_1
InParanoidiH3DKB8
OMAiPAKNGHT
TreeFamiTF351263

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF12796, Ank_2, 7 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 21 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3DKB8_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3DKB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 2, 2021
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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