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Entry version 35 (05 Jun 2019)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Cytoplasmic linker associated protein 2

Gene
N/A
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cytoplasmic linker associated protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 231TOGInterPro annotationAdd BLAST226
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati167 – 205HEATPROSITE-ProRule annotationAdd BLAST39
Domaini314 – 549TOGInterPro annotationAdd BLAST236
Domaini819 – 1059TOGInterPro annotationAdd BLAST241
Domaini1212 – 1453TOGInterPro annotationAdd BLAST242

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni545 – 603DisorderedSequence analysisAdd BLAST59
Regioni617 – 742DisorderedSequence analysisAdd BLAST126
Regioni789 – 811DisorderedSequence analysisAdd BLAST23
Regioni1057 – 1104DisorderedSequence analysisAdd BLAST48
Regioni1130 – 1168DisorderedSequence analysisAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1226 – 1257Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi545 – 569PolarSequence analysisAdd BLAST25
Compositional biasi584 – 601PolarSequence analysisAdd BLAST18
Compositional biasi632 – 703PolarSequence analysisAdd BLAST72
Compositional biasi720 – 742PolarSequence analysisAdd BLAST23
Compositional biasi794 – 811PolarSequence analysisAdd BLAST18
Compositional biasi1071 – 1104PolarSequence analysisAdd BLAST34
Compositional biasi1133 – 1147PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155574

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12348 CLASP_N, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01349 TOG, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

H3DHV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EHDNMDYFYQ QVLQKDVTRR LQVGQDLIDY LNDPQRSPDV EQDKPRLDKT
60 70 80 90 100
IDELTGWVNS SNFKVALLGI DICGAFVDRL GERFRGYLGT VLPALVDRLG
110 120 130 140 150
DGKDQVRENS QALILRCMEQ AASPMYIWER LLPGFKHKNF RSREGICLCV
160 170 180 190 200
SATLSTYGAQ PLSLSKLVPH LCFLTGDQNP QVREAAITTL VDVYRHVGER
210 220 230 240 250
VRADLGKRGL PAARLQTIFS RFDEALNSGN MALSPSHAET YDDHDCWMRG
260 270 280 290 300
KRCAAVQSVS QVSAPVWRRH SCSLMVGCSS VGIMWSVSKE SAGAVDEEDF
310 320 330 340 350
IKAFTDVPTV QIYSSRDLED NLNKIREICS DDKHDWDQRA NALKKIRSLL
360 370 380 390 400
VAGAPTYDCF YQHLRLLDGA FKLSAKDLRS QVVREACITV AHISTVLGNK
410 420 430 440 450
FDHGAEAIVP VLFNLIPNCA KVMATSGVSA IRIIIRHTHV PRLIPLITSN
460 470 480 490 500
CTSKSVAVRR RCYDFLDLLL QEWQTHSLES CRHTSVLVES IKKGIRDADS
510 520 530 540 550
EARMEARKAY WGLRNHFPAE ADALYNSLES SYQRTLQSCL KSSGSVASLP
560 570 580 590 600
QSDRSSSSSQ ESLNRPLTSK WSAPPGRVVL SVPTNSKGRV STTSLQRSRS
610 620 630 640 650
DVDVNAAAVA KHRYVGQTRA AGHLPPGSCS SLGRVRTKQP LSTPSSMSSQ
660 670 680 690 700
GDSRGRSRTK LVSQSQRSQS ATPVGAGSRS GSPGRVLTST ALSTMSSGAH
710 720 730 740 750
RVLAGSTTDG RRRSRIPRSQ GCSRDSSPTR LSVGSGFGIS QSSRLSSSVS
760 770 780 790 800
AMRVLNTGSD VEEALADALL LGDMRSKRKP ARRRYENYGM YSDDDANSDA
810 820 830 840 850
SSACSERSYS SRNGGAIPTY MRQTEDVAEV LNRCASANWS ERKEGLLGLQ
860 870 880 890 900
ALLKNQRTLS RVELKRLCEI FTRMFADPHS KRVFSMFLET LVDFILVHKE
910 920 930 940 950
DLQDWLFVLL TQLLKKMGAD LLGSVQAKVQ KALDVTRHRE SFPNDLQFTI
960 970 980 990 1000
LMRFTVDQTQ TPNLKVKVAI LRYIETLTLQ MEAPDFVNSS ETRLAVSRII
1010 1020 1030 1040 1050
TWTTEPKSSD VRKAAQSVLI SLFQLNTPEF SMLLAALPKT FQDGATKLLQ
1060 1070 1080 1090 1100
NHLKNTGSVA QAPMGSPLTR HTPRSPASWS SPVTSPTNTS QNTPSPSAFD
1110 1120 1130 1140 1150
YDTENMNSED IYSSLKGVTE AIRNFSVRSQ EDMNEPVQRR EGEECEIASV
1160 1170 1180 1190 1200
QGDSGTDGRG PDVMDGGRMA LDNKTSLLNT PLLSSSPRGT RDFLDSPFKH
1210 1220 1230 1240 1250
GRKDTSMDDS EHFADADSSL DQSELVAELL KELSNHNERV EERKAALCEL
1260 1270 1280 1290 1300
LKLIRENTLQ VWDEHFKTIL LLLLETMGDR EHVIRTLALR VLREILNKQP
1310 1320 1330 1340 1350
WRFKNYAELT IMKALEAHKD PHKEVVRAAE ETAAMLALSI SPDQCIKVLC
1360 1370 1380 1390 1400
PIIQSADYPI NLAAIKMQTK VMERVPRDGL ISLLPEIVPG LIQGYDNSES
1410 1420 1430 1440 1450
SVRKACVFCL VAIYTVIGED LKPHLSQLSS SKLKLLNLYI KRAQSGSSGS

EPPSE
Length:1,455
Mass (Da):161,343
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6CB8B9A99285B1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3C8E8H3C8E8_TETNG
Cytoplasmic linker associated prote...
1,514Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3C4V2H3C4V2_TETNG
Cytoplasmic linker associated prote...
1,226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3DHV2H3DHV2_TETNG
Cytoplasmic linker associated prote...
1,209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000020326; ENSTNIP00000020095; ENSTNIG00000016973

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTNIT00000020326; ENSTNIP00000020095; ENSTNIG00000016973

Phylogenomic databases

GeneTreeiENSGT00940000155574

Family and domain databases

Gene3Di1.25.10.10, 4 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG
PfamiView protein in Pfam
PF12348 CLASP_N, 2 hits
SMARTiView protein in SMART
SM01349 TOG, 4 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3DHV1_TETNG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3DHV1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 5, 2019
This is version 35 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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