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Entry version 44 (02 Jun 2021)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

KN motif and ankyrin repeat domains 1a

Gene
N/A
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
KN motif and ankyrin repeat domains 1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1073 – 1232ANK_REP_REGIONInterPro annotationAdd BLAST160
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1073 – 1095ANKPROSITE-ProRule annotationAdd BLAST23
Repeati1145 – 1177ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1178 – 1211ANKPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni37 – 104DisorderedSequence analysisAdd BLAST68
Regioni285 – 320DisorderedSequence analysisAdd BLAST36
Regioni763 – 791DisorderedSequence analysisAdd BLAST29
Regioni891 – 989DisorderedSequence analysisAdd BLAST99
Regioni1242 – 1264DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili243 – 263Sequence analysisAdd BLAST21
Coiled coili427 – 461Sequence analysisAdd BLAST35
Coiled coili794 – 814Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 104Polar residuesSequence analysisAdd BLAST64
Compositional biasi763 – 783Polar residuesSequence analysisAdd BLAST21
Compositional biasi891 – 942Polar residuesSequence analysisAdd BLAST52
Compositional biasi955 – 989Polar residuesSequence analysisAdd BLAST35

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysisARBA annotation, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154886

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3DDW9

Identification of Orthologs from Complete Genome Data

More...
OMAi
SGMMTGL

TreeFam database of animal gene trees

More...
TreeFami
TF324499

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR021939, KN_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 1 hit
PF12075, KN_motif, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H3DDW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EKDPYYVETP YGYQLDLDFL KYVNDIERGN TIKKLSIQRK PKVTKSLSVP
60 70 80 90 100
RGSTGGGSTQ AEWTSTDSLS SSNSDDKQSP VFFNPRSQSS SPATPTLPRQ
110 120 130 140 150
ATSEVPLQQP YLSITEQKPL LPPPSPRFAL RHNPQVERTL METRLRLEQE
160 170 180 190 200
RLLMQPHVDP PLPRRRLASF GGMGSSSSLS SYSGSIVQSQ ISPSAHPAFT
210 220 230 240 250
INGHPHNGEY NPYYPASMGS SIRHSPLSSG MATPVTNVSP LHLQQIREQM
260 270 280 290 300
VVALRRLKEL EEQVKTIPIL QVKIAVLQEE KRQMAAQSKN QGPGGFRKRS
310 320 330 340 350
YSVGSADQME NPGPFPKEPE LHIREPEAQE HSSQCLEEFR RLAAQVQALE
360 370 380 390 400
KTSQESNMDE VHSQKLLQNQ THQKSVGIVT DENMNSLPVL HGKLTSGLCF
410 420 430 440 450
QDAGVSTERP ESSSVAVGVT EAMLGVTSEA EKEIELQHQA IEALKDKIYR
460 470 480 490 500
LEVQLKETTH EMEMGKLKLE LQAAGGSNKK KADKGFMVRP EMYSVFVEAK
510 520 530 540 550
VQMRTQGVGN HLESSHANAA KSSQACTVGV SCQPSLESVA SGPEIPMDRW
560 570 580 590 600
VVHELVEVKD QCVGRRVETC DQLVGVEVNA CEAGVNTEES MGSLALSKAK
610 620 630 640 650
FSKESRSVGC GDCSVDVTVG PIKVLGSRGT NTDLISKVDS SVTAAPESAN
660 670 680 690 700
QQTNTDLEVV NKSTNTKTVV LTDCFTDMTF ITCDKHTNTA VTETRTVAAG
710 720 730 740 750
EGLVKDVTSA TKMRSIAVGT TASVDAFLGK SSCHTKNKEC GVGAVSIHDN
760 770 780 790 800
FLVGRNTRNI ACGPSQPNGS LTSKETTEVK ASPAPAQAQE GAGLDHYIER
810 820 830 840 850
VQKLLQEQQM LLAENYSELA DAFGQPQSQF GSINSQLVST LSSINTVMRY
860 870 880 890 900
GSSEDILKLQ SDPASLKDFQ ELGLTFLFFL IESSENLSSQ HAEMSSVQSS
910 920 930 940 950
AEPNRSSPAQ LQMNATTQKS SMDLQMSTAL HGQPSSQSTL KSIMKKKDGK
960 970 980 990 1000
PDSNGTKKNL QFVGVNGGYE TTSSDDSSSE DSSSTVSNSG FFQRYKPSEK
1010 1020 1030 1040 1050
MLAACSVLSA HLCDSKAVSS KDLRACVNTV QHEWFRVSSQ KTALATMVED
1060 1070 1080 1090 1100
YLSAFRDVSP AVLNHIANMA DGNGNTALHY SVSHSNFHVV KKLLDADVCN
1110 1120 1130 1140 1150
VNQQNKAGYT PIMLATLAAV DTPKDMRTVE ELFSKGDVNA RASQAGQTGL
1160 1170 1180 1190 1200
MLAVSHGRMD MVQALLAHGA NVNIQDDEGS TALMCASEHG HVEIVKLLLA
1210 1220 1230 1240 1250
QPGCDATLSD SDESNALSIA LEAGHKDIAV LLYAHVNFSK AQSPGTPRLG
1260
RKMSPSPTRR GMFD
Length:1,264
Mass (Da):136,923
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8167279700B90985
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3C562H3C562_TETNG
KN motif and ankyrin repeat domains...
1,125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000018939; ENSTNIP00000018712; ENSTNIG00000015638

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTNIT00000018939; ENSTNIP00000018712; ENSTNIG00000015638

Phylogenomic databases

GeneTreeiENSGT00940000154886
InParanoidiH3DDW9
OMAiSGMMTGL
TreeFamiTF324499

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR021939, KN_motif
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 1 hit
PF12075, KN_motif, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 5 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3DDW9_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3DDW9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 2, 2021
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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