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Entry version 54 (12 Aug 2020)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Arginine-glutamic acid dipeptide (RE) repeats a

Gene
N/A
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Arginine-glutamic acid dipeptide (RE) repeats aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

AcetylationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 289BAHInterPro annotationAdd BLAST182
Domaini290 – 393ELM2InterPro annotationAdd BLAST104
Domaini397 – 449SANTInterPro annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 93DisorderedSequence analysisAdd BLAST93
Regioni470 – 500DisorderedSequence analysisAdd BLAST31
Regioni548 – 1127DisorderedSequence analysisAdd BLAST580
Regioni1521 – 1548DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 38PolyampholyteSequence analysisAdd BLAST31
Compositional biasi470 – 492PolarSequence analysisAdd BLAST23
Compositional biasi562 – 577PolyampholyteSequence analysisAdd BLAST16
Compositional biasi583 – 629PolarSequence analysisAdd BLAST47
Compositional biasi630 – 689PolyampholyteSequence analysisAdd BLAST60
Compositional biasi696 – 719PolyampholyteSequence analysisAdd BLAST24
Compositional biasi720 – 757PolarSequence analysisAdd BLAST38
Compositional biasi758 – 772Pro-richSequence analysisAdd BLAST15
Compositional biasi773 – 813PolarSequence analysisAdd BLAST41
Compositional biasi814 – 859Pro-richSequence analysisAdd BLAST46
Compositional biasi863 – 897PolarSequence analysisAdd BLAST35
Compositional biasi900 – 924Pro-richSequence analysisAdd BLAST25
Compositional biasi940 – 975Pro-richSequence analysisAdd BLAST36
Compositional biasi976 – 1004PolarSequence analysisAdd BLAST29
Compositional biasi1005 – 1019Pro-richSequence analysisAdd BLAST15
Compositional biasi1056 – 1074PolarSequence analysisAdd BLAST19

Keywords - Domaini

Zinc-fingerARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153615

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3DCG7

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCRRLNS

TreeFam database of animal gene trees

More...
TreeFami
TF328554

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00202, ZnF_GATA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002951, Atrophin-like
IPR001025, BAH_dom
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR000679, Znf_GATA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03154, Atrophin-1, 2 hits
PF01426, BAH, 1 hit
PF01448, ELM2, 1 hit
PF00320, GATA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00439, BAH, 1 hit
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00401, ZnF_GATA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51038, BAH, 1 hit
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H3DCG7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LTVYLSRRPS RERTEEAGKS RRQDGERADR ESESSRPRRS CTLEGGAKNY
60 70 80 90 100
AESEHSEDED NDNGSTGGGS GTAEEAGKKG KKKTPKKKAR YERTENGEIT
110 120 130 140 150
SFITEDDIVY RPGDCVYIES RRPNTPYFIC SIQDFKLIHV CSHCCTDPPQ
160 170 180 190 200
TCRKPPHCFC RHVATMLPSH LSHGCKVAFD SKRDHLLMNV KWYYRQSEVP
210 220 230 240 250
DSVYQHLVQD RNNENDSGRE LVITDPVVRS RELFISDYVD TYHAAALRGE
260 270 280 290 300
VHISHFSDIF AAREFKARID SFFYILGYNP ETRRLNSTQG EIRVGPSHQA
310 320 330 340 350
KLPDLQPFPS PGGQAVTENE ELVWMPGVND CDLLMYLRAA RSMAAFAGMC
360 370 380 390 400
DGGSTEDGCL AASRDDTTLN ALNTLHESNY DAGKALQRLV KKPVPKLIEK
410 420 430 440 450
CWSEDEVKRF IKGLRQFGKN FFRIRKELLP NKETGELITF YYYWKKTPEA
460 470 480 490 500
ASCRAHRRHR RQPVFRRIKT RTASTPVNTP SRPPSSEFLD LSSASEDDFD
510 520 530 540 550
SEDSEQELKG YACRHCFTTT SKDWHHGGRE NILLCTDCRI HFKKYGELPP
560 570 580 590 600
IEKPVDPPPF MFKPVKEEED GLSGKHSMRT RRNRGSMSTL RSGRKKQTAS
610 620 630 640 650
PDGRASPTNE DLRSSGRTSP SAASTDSTDS KTESMKKPSK KIKEEAPSPM
660 670 680 690 700
KSAKRQREKG ASDTEEPERA SAKKSKTQEL SRPDSPSEGE GEGEGEGESS
710 720 730 740 750
DGRSINEELS SDPKDIDQDN RSSSPSIPSP RDNESDSDSS VQSQHPPVIQ
760 770 780 790 800
CQPGTSASSS APPPPTTSAP ALPPQVSPTA ASTTLPPQPL AQASPLSLIQ
810 820 830 840 850
SAASLHPQRL PSPHSPLTQA PPPCPPVPPP SLPSPHHGPM PPMPHPLQPG
860 870 880 890 900
PPHMPHPHSM PPQGFSLAQS QVPPLPVPGQ SQQRSHTPPS QSAAGGGQPP
910 920 930 940 950
REQPLPPAPM SMPHIKPPPT TPISQLANPQ SHKHPAHVSA PPFPQMPSNL
960 970 980 990 1000
PPPPALKPLS SLPTHHPPSA HPPPLQLMPQ GQQLQPPSAQ PPVLTQSQSL
1010 1020 1030 1040 1050
PPSASHQPPS APPLPPSAAA AASHPSGPPQ PPFATHPFSA VLPAAGPPPS
1060 1070 1080 1090 1100
SSGSMAGVPP PSSSAPSSSI SMPLPASVGC AGPGPALPPI HIKEEPLDEA
1110 1120 1130 1140 1150
EEPESPPPPQ RSPSPEPTVV NTPSHASQSA RFYKHLDRGY NSCARTDFYF
1160 1170 1180 1190 1200
TPLASSKLAA VSSLSLSLSL FFLFSCLPNH CFCPPPSQQK ASSSSHEPRM
1210 1220 1230 1240 1250
GEPQLAGPAH MRAPFDGPPT TIAAVPPYIG PDTPALRTLS EYARPHVMSP
1260 1270 1280 1290 1300
TNRNHPFFVS LNPADPLLAY HMPGLYNADP AMRERELRER EMREREIRER
1310 1320 1330 1340 1350
ELRERMKPGF EVKPPEMDAL HPSTNPMEHF ARHGAITLPP MAGPHPFASL
1360 1370 1380 1390 1400
HPGLNPLERE RLALAGPQLR PEMTYPERLA AERLHAERMA TVANDPIARL
1410 1420 1430 1440 1450
QMFNVTPHHH QHSHIHSHLH LHQQDPLHQG SGAHPLAVDP LAAGPHLARF
1460 1470 1480 1490 1500
PYPHGAIPNP LLGQPPHEHE MLRHPVFGTP YPRELPGGLP PPMSAAHQLQ
1510 1520 1530 1540
AMHAQSAELQ RLAMEQQWLH GHHPMHGGPL PGQEDYYSRL KKESDKQL
Length:1,548
Mass (Da):169,741
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05DD4CDF33CD68A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3DCG8H3DCG8_TETNG
Arginine-glutamic acid dipeptide (R...
1,547Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000018435; ENSTNIP00000018210; ENSTNIG00000015156

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTNIT00000018435; ENSTNIP00000018210; ENSTNIG00000015156

Phylogenomic databases

GeneTreeiENSGT00940000153615
InParanoidiH3DCG7
OMAiPCRRLNS
TreeFamiTF328554

Family and domain databases

CDDicd00202, ZnF_GATA, 1 hit
InterProiView protein in InterPro
IPR002951, Atrophin-like
IPR001025, BAH_dom
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR000679, Znf_GATA
PfamiView protein in Pfam
PF03154, Atrophin-1, 2 hits
PF01426, BAH, 1 hit
PF01448, ELM2, 1 hit
PF00320, GATA, 1 hit
SMARTiView protein in SMART
SM00439, BAH, 1 hit
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00401, ZnF_GATA, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51038, BAH, 1 hit
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3DCG7_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3DCG7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: August 12, 2020
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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