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Entry version 54 (07 Apr 2021)
Sequence version 1 (18 Apr 2012)
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Protein

Netrin receptor UNC5

Gene
N/A
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Netrin receptor UNC5UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 193Ig-likeInterPro annotationAdd BLAST81
Domaini493 – 634ZU5InterPro annotationAdd BLAST142

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the unc-5 family.UniRule annotationARBA annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182815

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014383_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3D7G2

Identification of Orthologs from Complete Genome Data

More...
OMAi
TYTSPIC

TreeFam database of animal gene trees

More...
TreeFami
TF316767

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 2 hits
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR037936, UNC5
IPR033772, UPA
IPR000906, ZU5_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12582, PTHR12582, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00531, Death, 1 hit
PF07679, I-set, 1 hit
PF00090, TSP_1, 2 hits
PF17217, UPA, 1 hit
PF00791, ZU5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00005, DEATH, 1 hit
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00209, TSP1, 2 hits
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48726, SSF48726, 1 hit
SSF82895, SSF82895, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS50092, TSP1, 2 hits
PS51145, ZU5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H3D7G2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LPRFLEEPVD AYIIKSNPIL RCQARPALQI FFKCNGEWVH QSQHMSQEHT
60 70 80 90 100
DLQTGLKIRE VMINVSRQQV EDFHGPEDYW CLCVAWSHLG TSKSRKATVR
110 120 130 140 150
IAYLRKNFEQ DPQGTEVPLN GMIVLHCRPP EGVPVAEVEW LKNEEALISE
160 170 180 190 200
GLTEKTGDHS LIISEAQLSD SGNYTCVASN IVAKRRSATA TVVVYVNGGW
210 220 230 240 250
SSWTDWSPCN VRCGRGMQKR SRTCTNPTPL NGGAFCEGMS VQKSTCSTLC
260 270 280 290 300
PVDGGWSEWS EWSACTSDCE RQRSRECTAP EPKHGGRLCD GVALATDNCT
310 320 330 340 350
GGLCTQNRKL LHDAKAQGVE SSSDVALYSG LAAGVVTVVL LIVAVTLYRR
360 370 380 390 400
SQSEYGVDVI DSSALTGGFQ SFSFKTSRQA NPLLINSSMQ PDLTVSRTYT
410 420 430 440 450
SPMCFQDSID KELMAEHSLL DPLPDLEIKD YYENPSIDSP GIAERAEYHV
460 470 480 490 500
QSHPQTFPRG LAPDYRAVGT MLGRRGNTLF APQACLPPSR HVHKATAVFG
510 520 530 540 550
RAGGRLVVPN TGISLLVPHG GITEDTSWEM YMIINQEDSS TVSEEESEIF
560 570 580 590 600
LSPTVTYGPP GLDLSCPIAV TVAHCAEVAA DNWTIRLKRQ AQDNKWEEVM
610 620 630 640 650
SVDEESTSCY CLLEAKRCHL LLEHPGRYAL VGAPMNPDAA KRLRLAVFGC
660 670 680 690 700
PDPSSALGFS LRVYCVDDTP NAFQEVAVGE RGRGGRLLEE PKTMLFRGSA
710 720 730 740 750
FSLQVSIQDV PQLLWSIKPF TTCQEFSFSQ VWASSRHPLQ CAFFLERYSH
760 770 780 790 800
SSSQLSCKIS VRQVKGEEQI LQVYTSVLEN EKTLVPCFSQ SDCTVTSQTG
810 820 830 840 850
SRAFKIPLSI RQRISATFDS ASTKGKDWQL LAQKLHIDRN LSYFACQESP
860 870 880 890
SSVILSLWEA QHQDTGDLDS LASALEEISK DQSSRTAALG GSR
Length:893
Mass (Da):98,504
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FB6E0D97DB13B16
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000016666; ENSTNIP00000016453; ENSTNIG00000013458

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTNIT00000016666; ENSTNIP00000016453; ENSTNIG00000013458

Phylogenomic databases

GeneTreeiENSGT00950000182815
HOGENOMiCLU_014383_0_0_1
InParanoidiH3D7G2
OMAiTYTSPIC
TreeFamiTF316767

Family and domain databases

Gene3Di2.20.100.10, 2 hits
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR037936, UNC5
IPR033772, UPA
IPR000906, ZU5_dom
PANTHERiPTHR12582, PTHR12582, 1 hit
PfamiView protein in Pfam
PF00531, Death, 1 hit
PF07679, I-set, 1 hit
PF00090, TSP_1, 2 hits
PF17217, UPA, 1 hit
PF00791, ZU5, 1 hit
SMARTiView protein in SMART
SM00005, DEATH, 1 hit
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00209, TSP1, 2 hits
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48726, SSF48726, 1 hit
SSF82895, SSF82895, 2 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS50092, TSP1, 2 hits
PS51145, ZU5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3D7G2_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3D7G2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 7, 2021
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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