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Entry version 57 (07 Apr 2021)
Sequence version 1 (18 Apr 2012)
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Protein

Neuropilin

Gene
N/A
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi171CalciumUniRule annotation1
Metal bindingi185CalciumUniRule annotation1
Metal bindingi226CalciumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinUniRule annotation, Heparin-bindingARBA annotation, ReceptorUniRule annotation
Biological processAngiogenesisARBA annotation, DifferentiationUniRule annotationARBA annotation, NeurogenesisUniRule annotationARBA annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NeuropilinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei834 – 859HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3 ↔ 30UniRule annotation
Disulfide bondi58 ↔ 80UniRule annotation
Disulfide bondi123 ↔ 149UniRule annotation
Disulfide bondi182 ↔ 204UniRule annotation
Disulfide bondi251 ↔ 400UniRule annotation
Disulfide bondi407 ↔ 559UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, Glycoprotein, Heparan sulfateARBA annotation, Proteoglycan

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 117CUBInterPro annotationAdd BLAST115
Domaini123 – 241CUBInterPro annotationAdd BLAST119
Domaini251 – 400F5/8 type CInterPro annotationAdd BLAST150
Domaini407 – 559F5/8 type CInterPro annotationAdd BLAST153
Domaini619 – 788MAMInterPro annotationAdd BLAST170

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neuropilin family.UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157169

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015228_6_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
HPYTNEW

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 2 hits
cd00057, FA58C, 2 hits
cd06263, MAM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 2 hits
2.60.120.290, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000859, CUB_dom
IPR000421, FA58C
IPR008979, Galactose-bd-like_sf
IPR000998, MAM_dom
IPR014648, Neuropilin
IPR022579, Neuropilin_C
IPR027146, NRP1
IPR035914, Sperma_CUB_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR46806:SF4, PTHR46806:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 2 hits
PF11980, DUF3481, 1 hit
PF00754, F5_F8_type_C, 2 hits
PF00629, MAM, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036960, Neuropilin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 2 hits
SM00231, FA58C, 2 hits
SM00137, MAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785, SSF49785, 2 hits
SSF49854, SSF49854, 2 hits
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 2 hits
PS01285, FA58C_1, 1 hit
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H3CTI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DKCGGNIRIS SASYLTSPGY PLSYSPSQRC TWVISAPGPH QRILINFNPH
60 70 80 90 100
FDLEDRECKY DYVEVRDGVD ESGQLVGKYC GKIAPSPVVS SGNQLFIKFV
110 120 130 140 150
SDYETHGAGF SIRYEIFKTG PECSRNFTSN SGVIKSPGFP EKYPNNLDCT
160 170 180 190 200
FMIFAPKMSE IILEFESFEL EPDQTPPAGV FCRYDRLEIW DGFPGVGPYI
210 220 230 240 250
GRYCGQNTPG RIISYTGILA LTINTDSAIA KEGFSANFTV IERTVPEDFD
260 270 280 290 300
CSDPLGMESG EIASEQIMAS SQYNPSWSPE RSRLNYYENA WTPAEDSNKE
310 320 330 340 350
WIQVDLGFLR FVSAIGTQGA ISQETQRIYF VKSYKVDVSS NGEDWITLKE
360 370 380 390 400
GSKQKIFQGN TNPTDVAKTM LPKPTLTRFV RIRPVTWETG IALRFEVYGC
410 420 430 440 450
KISEYPCSGM LGMISGLITD NQITASSHTD RNWVPENARL LTSRTGWTLL
460 470 480 490 500
PQPQPFASEW LQIDLGEEKL VKGLIIQGGK HRENKVFMKK FRLGYSNNGS
510 520 530 540 550
EWTMVFDTNG NKPKIFEGNG NYDTPELRIV EPLLTRFIRI YPERATPAGM
560 570 580 590 600
GLRLELLGCE IEAPTLPPTT AVPSTTPTDE CDDDQASCHS GTGDDYDVTG
610 620 630 640 650
ANIALMRLRA SPLPPFQWFA CDFGWASDPS FCSWTSEDTG SRWQIQSSGT
660 670 680 690 700
PTLNTGPNMD HTGGSGNFIY TLATGPQETK VARLVSPMVT SPDSDLCVSF
710 720 730 740 750
WYHMFGSHIG TLHIKQRKQT ADGPADILLW TVSGHQGSRW REGRVLVPQT
760 770 780 790 800
NKPYQVVIES LMDAKSWGDI AVDDIKVLNG LSMAECKGET FSVTNYTSCS
810 820 830 840 850
DLSSSAEDIT EYPDFVETNQ ISGPGNMLKT LDPILITIIA MSALGVFLGA
860 870 880 890 900
ICGVVLYCAC SHGGMSDRNL SALENYNFEL VDGVKSKKDK LNVQNSYLEA
Length:900
Mass (Da):99,652
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B6BAF9EB0D8C19C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3CTI6H3CTI6_TETNG
Neuropilin
935Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000011753; ENSTNIP00000011571; ENSTNIG00000008719

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTNIT00000011753; ENSTNIP00000011571; ENSTNIG00000008719

Phylogenomic databases

GeneTreeiENSGT00940000157169
HOGENOMiCLU_015228_6_1_1
OMAiHPYTNEW

Family and domain databases

CDDicd00041, CUB, 2 hits
cd00057, FA58C, 2 hits
cd06263, MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000859, CUB_dom
IPR000421, FA58C
IPR008979, Galactose-bd-like_sf
IPR000998, MAM_dom
IPR014648, Neuropilin
IPR022579, Neuropilin_C
IPR027146, NRP1
IPR035914, Sperma_CUB_dom_sf
PANTHERiPTHR46806:SF4, PTHR46806:SF4, 1 hit
PfamiView protein in Pfam
PF00431, CUB, 2 hits
PF11980, DUF3481, 1 hit
PF00754, F5_F8_type_C, 2 hits
PF00629, MAM, 1 hit
PIRSFiPIRSF036960, Neuropilin, 1 hit
SMARTiView protein in SMART
SM00042, CUB, 2 hits
SM00231, FA58C, 2 hits
SM00137, MAM, 1 hit
SUPFAMiSSF49785, SSF49785, 2 hits
SSF49854, SSF49854, 2 hits
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 2 hits
PS01285, FA58C_1, 1 hit
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3CTI7_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3CTI7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 7, 2021
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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