Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 58 (12 Aug 2020)
Sequence version 1 (18 Apr 2012)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Spectrin beta chain

Gene

SPTBN1

Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin cappingUniRule annotationARBA annotation, Actin-bindingUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin beta chainUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPTBN1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 161Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini173 – 278Calponin-homology (CH)InterPro annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili116 – 136Sequence analysisAdd BLAST21
Coiled coili457 – 491Sequence analysisAdd BLAST35
Coiled coili712 – 732Sequence analysisAdd BLAST21
Coiled coili817 – 837Sequence analysisAdd BLAST21
Coiled coili991 – 1025Sequence analysisAdd BLAST35
Coiled coili1097 – 1124Sequence analysisAdd BLAST28
Coiled coili1422 – 1449Sequence analysisAdd BLAST28
Coiled coili1852 – 1872Sequence analysisAdd BLAST21
Coiled coili1984 – 2004Sequence analysisAdd BLAST21
Coiled coili2051 – 2071Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154864

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000146_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3CNY5

Identification of Orthologs from Complete Genome Data

More...
OMAi
SKWDHLL

TreeFam database of animal gene trees

More...
TreeFami
TF313446

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR016343, Spectrin_bsu
IPR002017, Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 17 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002297, Spectrin_beta_subunit, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H3CNY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EVEMTSVAAE FEHMEIQQQF NDGVNNRWDA DDWDNENSSA RLFERSRIKA
60 70 80 90 100
LADEREAVQK KTFTKWVNSH LSRVSCRITD LYMDLRDGRM LIKLLEVLSG
110 120 130 140 150
EKLPKPTKGR MRIHCLENVD KALQFLKEQR VHLENMGSHD IVDGNHRLTL
160 170 180 190 200
GLIWTIILRF QQIQDISVET EKKSAKDALL LWCQMKTAGY SNVNIHNFTT
210 220 230 240 250
SWRDGMAFNA IIHKHRPDLI DFDKLKKSNA HYNLQNAFNL AEQHLGLTKL
260 270 280 290 300
LDPEDISVDH PDEKSIITYV VTYYHYFSKM KALKVEGKRI GKVLDHAIET
310 320 330 340 350
EKMIEKYESL ASDLLEWIEQ TIIILNNRKF ANSLVGVQQQ LQAFNTYRTV
360 370 380 390 400
EKPPKFTEKG NLEVLLFTIQ SKMRANNQKV FTPREGKLIS DINKAWERLE
410 420 430 440 450
RAEHERELAL RTELIRQEKL EQLARRFDRK AAMRETWLSE NQRLVSQDNF
460 470 480 490 500
GCDLQAVEAA TKKHEAIETD IAAYEERVQA VVAVAKELEA ESYHDIKRVT
510 520 530 540 550
ARKDNVTRLW EYLLELLKAR RQRLEMNLGL QRVFQEMLYI MDWMDEMKML
560 570 580 590 600
LLSQDYGKHL LGVEDLLQKH ALVEADIGIQ ADRVRNVNSN AQKFAMDVEG
610 620 630 640 650
YRPCDPQVIQ DRVTHMDFCY QELSQLAAER RARLEESRRL WKFFWEMAEE
660 670 680 690 700
EGWIREKEQI LSSEDHGKDL TGALRLLSQH KALEDEMSGR AGHLQQTIRQ
710 720 730 740 750
GEELVANHHF GADKIKERIQ DIQAQWAELE RLSAVRKSRL QEACNKHQFQ
760 770 780 790 800
ADADDIDTWM LDILRIVSSV DVGHDEFSTQ ALVKKHKDVA EEMGSYRPVI
810 820 830 840 850
DALHEQSRAL PVDGADSEEV QNRLAGIEER YKEVVELTRL RKQALQDALT
860 870 880 890 900
LYKMFSEANA CEAWIDEKEQ WLNSMDIPEK LEDLEVVQHR FESLEPEMNN
910 920 930 940 950
QASRVAVVNQ VARQLIHSGH PSEKEIKSQQ DKLNTRWSQF RDLADQKKDA
960 970 980 990 1000
LNSALGVQNY HLECNETKSW IKEKTKVIES TQELGNDLAG VMALQRKLTG
1010 1020 1030 1040 1050
MERDLVAIED KLGDLGKEAE RLASEHPDQS QTIKGRLAEI THVWGEMKDT
1060 1070 1080 1090 1100
MKNREESLGE ASKLQQFLRD LDDFQSWLSR TQTAIASEDM PNTLAEAEKL
1110 1120 1130 1140 1150
LAQHEGIKNE IRNYEEDYQK MRDMGEMVTQ GQTDAQYMFL RQRLQALDTG
1160 1170 1180 1190 1200
WNELHRMWEN RQNLLSQSHS YQLFLRDTKQ AEAFLNNQEY VLAHTEMPTT
1210 1220 1230 1240 1250
LEAAEASIKK QEDFMTTMDA NEEKIIGVVD AGRRLVADGN INSERIQEKV
1260 1270 1280 1290 1300
DSIDQRHKKT RAAAVELLDR LKDNRDLQKF LQDCQELSLW IGEKMLTAQD
1310 1320 1330 1340 1350
MTYDEARNLH SKWLKHQAFM AELQSNKEWL DKIDKDGQTL MLEKPDTEAM
1360 1370 1380 1390 1400
VQEKLAWLKS TWAELESTTQ TKAKCLFDAN KAELFTQSCA DLDKWLGSLE
1410 1420 1430 1440 1450
AQLQSDEYGK DLTSVNILLK KQQILESQVE VRQKEVEELQ NQSQVLSQEG
1460 1470 1480 1490 1500
KGSEEVDGQR VSVERKFHLL LEPLKKRRDN LMVSREIHQF NRDVEDEILW
1510 1520 1530 1540 1550
VEERLPVAMS TDHGHNLQTV QLLIKKNQTL QKEIQGHQPR YDDIFERSQH
1560 1570 1580 1590 1600
VLREDGPTAQ LIGQRLAELT SLWQRIGEEA EKRHERLSEA HRAQQYYFDA
1610 1620 1630 1640 1650
AEAEAWMSEQ ELYMMSEEKA KDEQSSVFML KKHQILEQAV EDYADTVHQL
1660 1670 1680 1690 1700
SATSRGLVAA GHPESERIGM RQSQVDKLYA GLKDLSEERR GKLDERFRLF
1710 1720 1730 1740 1750
QLNREVDDLE QWIAEREVVA GSHELGQDYE HVTMLQERFR EFARDTGTIG
1760 1770 1780 1790 1800
QERVDAVNRQ ADELINAGHS DAATIAEWKD GLNEAWADLL ELIDTRTQIL
1810 1820 1830 1840 1850
AASYELHQFY HDAKEILSRI LDKHKKLPEE LGRDQNTVET LQRMHTAFEH
1860 1870 1880 1890 1900
DIQALGTQVR QLQEDATRLQ AAYAGDKADD IQKREAEVLE AWKNLLEAVE
1910 1920 1930 1940 1950
GRRLKLVDTG DKFRFFSMVR DLMLWMEDVI RLIEAQENPR DVSSVELLMN
1960 1970 1980 1990 2000
NHQGIKAEID ARNDSFTCCI ELGKTLLARK HYASEEIKEK LLQLTDKRKE
2010 2020 2030 2040 2050
MIDKWEDRWE WLRLVLEVHQ FSRDASVAES WLLGQEPYLS SREVGQNADE
2060 2070 2080 2090 2100
VEKLIKRHEA FEKSAATWEE RFSALERLTT MELLEVRRVQ EEEEKKRQAP

PTEAQLTD
Length:2,108
Mass (Da):245,337
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94167FCC845025C7
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000010147; ENSTNIP00000009968; ENSTNIG00000007166

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTNIT00000010147; ENSTNIP00000009968; ENSTNIG00000007166

Phylogenomic databases

GeneTreeiENSGT00940000154864
HOGENOMiCLU_000146_1_2_1
InParanoidiH3CNY5
OMAiSKWDHLL
TreeFamiTF313446

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR016343, Spectrin_bsu
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 17 hits
PIRSFiPIRSF002297, Spectrin_beta_subunit, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 17 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3CNY5_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3CNY5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: August 12, 2020
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again