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Entry version 63 (02 Jun 2021)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Ryanodine receptor 1

Gene

RYR1

Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Calmodulin-bindingARBA annotation, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ryanodine receptor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RYR1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4242 – 4262HelicalSequence analysisAdd BLAST21
Transmembranei4456 – 4476HelicalSequence analysisAdd BLAST21
Transmembranei4539 – 4561HelicalSequence analysisAdd BLAST23
Transmembranei4678 – 4699HelicalSequence analysisAdd BLAST22
Transmembranei4737 – 4757HelicalSequence analysisAdd BLAST21
Transmembranei4816 – 4839HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulumARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini97 – 152MIRInterPro annotationAdd BLAST56
Domaini159 – 204MIRInterPro annotationAdd BLAST46
Domaini212 – 267MIRInterPro annotationAdd BLAST56
Domaini273 – 336MIRInterPro annotationAdd BLAST64
Domaini338 – 395MIRInterPro annotationAdd BLAST58
Domaini586 – 796B30.2/SPRYInterPro annotationAdd BLAST211
Domaini1012 – 1208B30.2/SPRYInterPro annotationAdd BLAST197
Domaini1341 – 1553B30.2/SPRYInterPro annotationAdd BLAST213

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1332 – 1362DisorderedSequence analysisAdd BLAST31
Regioni1844 – 1875DisorderedSequence analysisAdd BLAST32
Regioni3422 – 3448DisorderedSequence analysisAdd BLAST27
Regioni4297 – 4425DisorderedSequence analysisAdd BLAST129

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili460 – 480Sequence analysisAdd BLAST21
Coiled coili2863 – 2883Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3433 – 3448Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi4392 – 4425Basic and acidic residuesSequence analysisAdd BLAST34

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155288

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3CFT0

Identification of Orthologs from Complete Genome Data

More...
OMAi
KIAMPCL

TreeFam database of animal gene trees

More...
TreeFami
TF315244

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 2 hits
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 3 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H3CFT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEGGEGEEE IQFLRTDDQV VLQCTASVLK EQIKLCLSCE GFGNRLCFLE
60 70 80 90 100
TTSNAQNVPP DLAICTFILE QSLSVRALQE MLANTVEMTE SSQGGGHRTL
110 120 130 140 150
LYGHAILLRH NHSAMYLSCL TTSRSLTDKL AFDVGLQEDS TGEACWWTIH
160 170 180 190 200
PASKQRSEGE KVRVGDDLIL VSVSSERYLH LSYASGDLMV DASFMQTLWN
210 220 230 240 250
MNPISSGCEL AEGFLTGGHV LRLFHGHMDE CLAIATPEEG EEKRRMAHYE
260 270 280 290 300
GGSVCSQARS LWRLEPLRIS WSGSHMKWGQ SFRIRHITTG RYLCLDEEKG
310 320 330 340 350
LLVVDPERAD TKHSAFCFRA SKEKVDVAQK RDVEGMGIPE IKYGESMCFV
360 370 380 390 400
QHVSTGLWLT YAALDAKAAR LGMMKRKVIL HQEGHMDDAL TVSRSQTEES
410 420 430 440 450
QAARMIYSTV GLFRQFIKGL DTLTGKNKSP GAVALPLEGV ILSLQDLIFY
460 470 480 490 500
FRPPDEELEH EEKQTKLRSL RNRQNLFQEE GMITIVLECI DRLNVYNTAA
510 520 530 540 550
HFSEFAGEEA AESWKEIVNL LYELLASLIR GNRSNCALFT NLDWLVSKLD
560 570 580 590 600
RLEASLSILE VLYCVLIESP EVLNIIQENH IKSIISLLDK HGRNHKVLDV
610 620 630 640 650
LRSLCVCNGV AVRSNQNLIT ENLLPGRDLL LQTNIVNYVT SVRPNIFLGT
660 670 680 690 700
CEGSTQYKKW YYEVMVDHVE SFVTQQATHL RVGWAMTDGY SPYPGGGEGW
710 720 730 740 750
GGNGVGDDLY SYGFDGLHLW SGTVPRQVAS PSAHTLAADD VVSCCLDLSV
760 770 780 790 800
PSISFRINGH PVQGMFENFN VDSLFFPVIS FSAGVKARFL LGGRHGDFKF
810 820 830 840 850
MPPPGYAPCY EALLPRERMR IEPIKEYKHD FSGVRNLLGP TLSLTHTSFT
860 870 880 890 900
PCPVDTVQIV LPPHLERIRE KLAENIHELW AITRIEQGWT YGVFRDDNKK
910 920 930 940 950
LHPCLVDFQS LPEPERNYNL QMSGETLKTL LALGCHVGMG DEKAEENLKK
960 970 980 990 1000
IKLPKTYVMS NGYKPAPLDL SHVRLTPNQN QLVEKLAENG HNVWARDRVR
1010 1020 1030 1040 1050
QGWTYSIVQD ILNKRNPRLV PYVLLDEKTK KTNRDSVNNA VRTLIGYGYN
1060 1070 1080 1090 1100
IEPPDQESTG HGLENTRGDK VRIFRAEKSY AITQGKWYFE FEAVTTGEMR
1110 1120 1130 1140 1150
VGWARPNVRS DTELGADELA YVFNGNKAQR WHIGNEPFGR QWQSGDVVGC
1160 1170 1180 1190 1200
MIDLTEMNIM FTLNGEMLIS DSGSEMAFKD IEIGEGFIPV CTLGLSQVGR
1210 1220 1230 1240 1250
INLGQNVSSL RYFAICGLQE GFEPFAINMK RDTTMWFSKS LPQFVPVPTD
1260 1270 1280 1290 1300
HNHIEVSRVD GTVDSAPCLK LTHKTYGSQN ANTDMLFLRL SMPIQFHTTF
1310 1320 1330 1340 1350
KIPAGTTPLT RALNIPEDIA VVEPDSEFEV LKKSASRKEQ EEDKKEPSVP
1360 1370 1380 1390 1400
KEVLAENEKD TVSEKGKKRG FFSKAKKAAM TPLAPPPAPP TVPRLVEDVV
1410 1420 1430 1440 1450
PDDRDDPEII LSTTTYYYSV RIFAGQEPSG VWVGWVTPDY HQYDQTFDLS
1460 1470 1480 1490 1500
KVRSVTVTVG DDKGNIYNSM KHSNCYMVWG GDLVSNHQTR FSQEDMVIGC
1510 1520 1530 1540 1550
LVDLATGLMT FTANGKEINT FYQVEPNTKL FPAVFIQPLS QNLVQLELGK
1560 1570 1580 1590 1600
LKNIMPISAA MFRSERNNPV PQCPPRLDVQ MLTPVIWSRM PNRFLNPEVG
1610 1620 1630 1640 1650
RVSERLGWVV ECTEPLIMMA LHIPEENRCI DILELSERQD LMKFHYHTLM
1660 1670 1680 1690 1700
LYCAVCALGN NRVAHALCSH VDESQLFYAT ENTYLPGPLR SGYYDLLISI
1710 1720 1730 1740 1750
HLESAKRARL GTNREFIVPM TEETLSIKLY PDAVKAHSLP GVGLTTCLRP
1760 1770 1780 1790 1800
KLHFSSINFV GTDPDLYTLS PVFPLQELKT RAISMLTEAV LDGSQAMRDP
1810 1820 1830 1840 1850
VGGSVEFHFV PILKLINTLL IMGIFNDEDT KHILKMIDPN VFSGKDEEED
1860 1870 1880 1890 1900
TEKPTEGGTA EDDKAKEEES EEAAELLQMK LPESVKLQMC TLLQFFCDCE
1910 1920 1930 1940 1950
LRHRVEAIVA YSDKFVHDIQ DNQRIRYNQL MRAFTMSAAE TARKTREFRS
1960 1970 1980 1990 2000
PPQDQVLLLT NFKHSLEDEE CPVPDDVRDT LKEFHNDLLL HCGIHIEEEA
2010 2020 2030 2040 2050
VEEEVDTSLR GRLLSLVDKI KSLRGKKTEE KPEVEEETKP STLQELISHT
2060 2070 2080 2090 2100
MIHWAQESFI QNPELVRLMF SLLHRQYDGL GELIRALPKA YAINAVSVQD
2110 2120 2130 2140 2150
TMDLLECLGQ IRSLLIVQMG PEEERLMIQS IGNIMNNKVF YQHPNLMRAL
2160 2170 2180 2190 2200
GMHETVMEVM VNVLGGGDSK EIRFPQMVTN CCRFLCYFCR ISRQNQRSMF
2210 2220 2230 2240 2250
DHLSYLLQNS SIGLGMRGST PLDVAAASCI DNNELALALQ EQDLEMVVMY
2260 2270 2280 2290 2300
LASCGLQMCP MLLSKGYPDI GWNPCGGERY LDFLRFAVFV NGESVEENAN
2310 2320 2330 2340 2350
VVVRLLIRRP ECFGPALRGE GGNGLLAAME EAIKISEDPA RDGPTVKKDR
2360 2370 2380 2390 2400
RFMFGGEEQQ EENRVHLGNA IMSFYSALID LLGRCAPEMH LIQAGKGEAL
2410 2420 2430 2440 2450
RIRAILRSLV PIEDLVGVIS LPVQIPSYGK DGQIIEPKMS ASFVPDHKAS
2460 2470 2480 2490 2500
MVLFLDRVYG IDNQDFLLHV LEVGFLPDMR ASASLDTVAF STTEMALALN
2510 2520 2530 2540 2550
RYLCSAVLPL LTKCAPLFAG TDHRAIMIDS MLHTIYRLSR GRALTKAQRD
2560 2570 2580 2590 2600
VIEECLMSLC KYLRPSMLQH LLRRLVFDVP ILNEYAKMPL KLLTNHYERC
2610 2620 2630 2640 2650
WKYYCLPNGW ANFGVTSEEE LHLSRKLFWG IFESLAHKKF DAELFKIAMP
2660 2670 2680 2690 2700
CLCAIAGAIP PDYVDASYSS HTEKKASVDA EGNFDPKPVE TTNTIIPERL
2710 2720 2730 2740 2750
DTFINKYAEH THDKWAFEKI QNNWTYGEVL DENAKTHPML RPYKTFSEKD
2760 2770 2780 2790 2800
KEIYRWPIKE SIKAMLAWEW TLEKARDGEG EVEKKAATRK ISQTAQATYD
2810 2820 2830 2840 2850
PSHGYSPQPI DISGMALSRE LQSMAEQLAE NYHNTWGRKK KLELQSKGGG
2860 2870 2880 2890 2900
THPLLVPYDT LTAKEKARDR EKAQDLLKFL QLNGYAVTRG MKDMEQDISS
2910 2920 2930 2940 2950
IEKRFAYGFL QKLLKWMDIA QEFIAHLESE AVVSSGRVEK SPHEQEIKFF
2960 2970 2980 2990 3000
AKILLPLVNQ YFKNHCLYFL STPAKVLGSG GHSSNKEKEM IASIFCKLAA
3010 3020 3030 3040 3050
LVRHRVSLFG TDAGAVVNCL HILSRSLDAR TVMKSGPEIV KAGLRQFFES
3060 3070 3080 3090 3100
AADDIEKMVE NLKLGKVSSR NQVKGVSQNI NYTTIALLPV LTSLFDHIAQ
3110 3120 3130 3140 3150
HQFGDDVILD DLQISCYRIM CSIYSLGTVK TPHAEKQRPA LGECLAHLAA
3160 3170 3180 3190 3200
AMPVAFLEPV LNEFNMFSVY TTKTPRERTI LGLPNQVEEL CPDIPELEVL
3210 3220 3230 3240 3250
MKDIHDLAES GARYTEMPHV IEITLPMLCN YLPRWWERGL ENFPEQEGQL
3260 3270 3280 3290 3300
CTSVTSEQLN QLLGSIMKIV VNNLGIDEAS WMKRLAVFAQ PIVSRAKPEM
3310 3320 3330 3340 3350
LKSHFIPTME KLKKRSGKVV AEEDHLRMEG KTEVDSENGT IRDEFAVLCR
3360 3370 3380 3390 3400
DLYALYPLLI RYVDNNRARW LTNPDPDAEE LFRMVGEVFI FWSKSHNFKR
3410 3420 3430 3440 3450
EEQNFVVMNE INNMSFLTAD SKSKMSKAGD GESGGSEQER TKKKRRGDRY
3460 3470 3480 3490 3500
SVQTSLIVAA LKKLLPIGLN MCSPADQELI NLAKIRYSLK DTDEEVREFL
3510 3520 3530 3540 3550
HNNLHLQGKV EDPAMRWQMS LYKEMAGKAE DAEDPEKVVK RVQEVSAVLY
3560 3570 3580 3590 3600
HIEVTEHPFK SKKMVWHKLL SKQRRRAVVA CFRMTPLYNI ITHRATNMFL
3610 3620 3630 3640 3650
DAYKRNWLET EGYSFQDKMI DDLSVSSDHS NEMSSRKERK PDPLHQLILH
3660 3670 3680 3690 3700
LSRTALTEKT KLDVDHLYKN YAEIMAKACY ITFSTGASSF ERFQRSSSSS
3710 3720 3730 3740 3750
ASQEKEMEIQ RLLYQQSRLH NRGAAEMVLQ MISACKGEPG AMVSSTLKLG
3760 3770 3780 3790 3800
ISILNGGNSD VQQKMLDYLK DKKDVGFFLS VQSLMQTCSV LDLNAFERQN
3810 3820 3830 3840 3850
KAEGLGMVSE EGTSLSSTDS HEIPGLTVSL FGFLSPSFAL HAAVQQNRLM
3860 3870 3880 3890 3900
HPDPGQRTGV RICVIFMPCH VFHLSKTLSH LHFLTLPKSL TATGNSFLLC
3910 3920 3930 3940 3950
WCRFFRNACS NSTNVIVHAH LFVTLTELYF CFAVFFLTFL QDSSQIGLLK
3960 3970 3980 3990 4000
ELLDLQKDMV VMLLSLLEGN VVNGTIAKQM VDMLVESSSN VEMILKFFDM
4010 4020 4030 4040 4050
FLKLKDIVAS DAFRDYVTDP RGLISKKDFS KAMDSQKQYT PGEIQFLLSC
4060 4070 4080 4090 4100
SEADENEMIN FEEFADRFQE PAKDIGFNIA VLLTNLSEHV PHDTRLQNFL
4110 4120 4130 4140 4150
EQAESVLNYF RPFLGRIEIM GASRKIERIY FEISEANRNQ WEMPQVRESK
4160 4170 4180 4190 4200
RQFIFDVVNE GGESEKMEMF VNFCEDTIFE MNIAASISEP EGDDGNGEEQ
4210 4220 4230 4240 4250
APESTSAFAD FIKSVVNFFN MFTFRNLRRR YRRFRKMTVK EMVIGLVTFV
4260 4270 4280 4290 4300
YTVLMGILMF VYSICKGFFT LIWKVLFGGG LVESAKKMTV TDILASMPDP
4310 4320 4330 4340 4350
TQDEVHGELP PEPGSREVQD TEGGADLLDP VGGEEEEEDS EEREGGRLPG
4360 4370 4380 4390 4400
FNTPGGLGDF GETTPEEPPT PEGTPLLKRK LLSVSFMSST ENGEKAEKEP
4410 4420 4430 4440 4450
EPEPEPKEEE PAEKEEAAVK TKAKKSKKPV EEGFELWNEL EIQRVKFMNY
4460 4470 4480 4490 4500
LSRNFYNLRF LALFIAFAVN FILLFYKVSD SPPGEEDFEG SGLFEGSGLF
4510 4520 4530 4540 4550
EGSGAPEDGS GFDDGGEDDE EEGPLYYFLE ESTGYMEPAM AFLSIVHTII
4560 4570 4580 4590 4600
SFLCIIGYNC LKVPLVIFKR EKELARKLEF DGLYVTEQPE DDDIKGQWDR
4610 4620 4630 4640 4650
LVLNTPTFPN NYWDKFVKRK VLDKYGDIYG RERIAELLGM DLASLDVSAM
4660 4670 4680 4690 4700
THEKKPEPDT SMFSWITSID VKYQIWKFGV VFTDNTFLYL VWYLLMSILG
4710 4720 4730 4740 4750
HYNNFFFAAH LLDIAMGVKT LRTILSSVTH NGKQLMMTVG LLAVVVYLYT
4760 4770 4780 4790 4800
VVAFNFFRKF YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE
4810 4820 4830 4840 4850
DPAGDEYELY RVVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVRE
4860 4870 4880 4890 4900
DMETKCFICG IGSDYFDTTP HGFETHTLEE HNLANYMFFL MYLINKDETE
4910 4920 4930
HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLG
Length:4,935
Mass (Da):559,289
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6174DF866B7003D8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3DNV5H3DNV5_TETNG
Ryanodine receptor 1
RYR1
4,930Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSTNIT00000007264; ENSTNIP00000007107; ENSTNIG00000019014

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTNIT00000007264; ENSTNIP00000007107; ENSTNIG00000019014

Phylogenomic databases

GeneTreeiENSGT00940000155288
InParanoidiH3CFT0
OMAiKIAMPCL
TreeFamiTF315244

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 3 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3CFT0_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3CFT0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 2, 2021
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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