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Entry version 51 (17 Jun 2020)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

TSC22 domain family member 1

Gene

TSC22D1

Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TSC22 domain family member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSC22D1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 82DisorderedSequence analysisAdd BLAST82
Regioni96 – 123DisorderedSequence analysisAdd BLAST28
Regioni136 – 238DisorderedSequence analysisAdd BLAST103
Regioni293 – 312DisorderedSequence analysisAdd BLAST20
Regioni356 – 382DisorderedSequence analysisAdd BLAST27
Regioni404 – 439DisorderedSequence analysisAdd BLAST36
Regioni455 – 514DisorderedSequence analysisAdd BLAST60
Regioni577 – 606DisorderedSequence analysisAdd BLAST30
Regioni653 – 729DisorderedSequence analysisAdd BLAST77
Regioni778 – 799DisorderedSequence analysisAdd BLAST22
Regioni903 – 926DisorderedSequence analysisAdd BLAST24
Regioni1015 – 1049DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili974 – 1008Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 25PolarSequence analysisAdd BLAST17
Compositional biasi41 – 82PolarSequence analysisAdd BLAST42
Compositional biasi367 – 381PolarSequence analysisAdd BLAST15
Compositional biasi469 – 493PolarSequence analysisAdd BLAST25
Compositional biasi577 – 595PolarSequence analysisAdd BLAST19
Compositional biasi905 – 919PolarSequence analysisAdd BLAST15
Compositional biasi1034 – 1049PolarSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4797 Eukaryota
ENOG4111MFI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159144

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010450_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3CDQ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
SIVNPQT

TreeFam database of animal gene trees

More...
TreeFami
TF318837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000580 TSC-22_Dip_Bun

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01166 TSC22, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01289 TSC22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H3CDQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHSAVFHRK GSNTGSGSSV LSPPANSHVP ADDYQPSLLI QCQAPAGSSS
60 70 80 90 100
PGTHHIPPHS LNLHSQPQPT QPTGAQMKKK SGFQITSVTP AQISVSTNNS
110 120 130 140 150
IAEDTESYDD LDESHTEDLS SSEILDVSLS RANDVVGAER SSSEETLNNF
160 170 180 190 200
QEAETPGAIS PNQPSHPHTL NQAQQRSGSL VNGTVHPQHP NHAVYSLSSV
210 220 230 240 250
PASPSSALNS GALTSVTQKM PSNSGVSQES VSQVAHPSIN PQPVGVVALG
260 270 280 290 300
SSPGLHGSAP ATTVSIMNPQ TSSVSNVNIL SSANVPVREG ISASGTSGFP
310 320 330 340 350
HHGMSSSGGA AAAAGGNLIP AASAGVSQQL QHPNNSTVPM TTTSVAAAAA
360 370 380 390 400
AAGRRLWGGG SPRWRPGQGR SRTSSRFRVV KLDSSSEPFK KGRWTCTEFY
410 420 430 440 450
DKETSLSSAG DSGSPSARPL APESSAGASE RDSASASSVS SSLSTLSHYS
460 470 480 490 500
EIVCGGEAGG PPIPQHDYSS LPQGFQGTPQ SVGLPQTQTP MLPPEAHSKP
510 520 530 540 550
GVAPSATANA HPPARVSSLQ ATNGLPTPAV HQFTYAQAVA SPPAAPAQGL
560 570 580 590 600
VGVKQQKIGT PPSYSPHPLT RKLPPCSQTH QGVLQGQTGS APPPAGPANG
610 620 630 640 650
SSPMMGALQQ PQTLLHAPPQ QPSAHLAPMS GLGSLAGGAA GLGPLAQNHP
660 670 680 690 700
AHLEHQKPQS LPTQIPNTGQ GNQMATPVQS SQVSAPSAPA PNPQSDPQAG
710 720 730 740 750
SLPSSGRVAP QGIPQNQQSS AGLSQEHSSA QALAHAAQAS ALYASLPTFT
760 770 780 790 800
TTQLQDAQRL LLQHQSALLG LPKLPAGGGG GEAASGFGTS QGQDTEGNAA
810 820 830 840 850
AAASALGASA GSKAVDGEED GALRMNCVPP EVAEQVKDAT RGGRKAAPVP
860 870 880 890 900
HSHAPTAALT VPLAQQNRLS LLRFKGETLH DGLRGLKSEG CCCHPPKHAG
910 920 930 940 950
NVLNHGRHSS GSNAAQSAPA PAPVSLPSPL SPVHGARLAP PLVDFVQLIS
960 970 980 990 1000
SGASVVAIDN KIEQAMDLVK SHLMYAVREE VEVLKEQIKE LIERNSQLEQ
1010 1020 1030 1040
ENTLLKTLAS PEQMAQFQAQ VQTGSPPAPG PPSAATFTQT APHSSGPSA
Length:1,049
Mass (Da):106,743
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DDEA69DEC8427A3
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000006528; ENSTNIP00000006379; ENSTNIG00000003779

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTNIT00000006528; ENSTNIP00000006379; ENSTNIG00000003779

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG4111MFI LUCA
GeneTreeiENSGT00940000159144
HOGENOMiCLU_010450_1_0_1
InParanoidiH3CDQ6
OMAiSIVNPQT
TreeFamiTF318837

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3CDQ6_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3CDQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 17, 2020
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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