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Entry version 59 (07 Apr 2021)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Low density lipoprotein receptor-related protein 6

Gene
N/A
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorARBA annotation
Biological processEndocytosisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Low density lipoprotein receptor-related protein 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500358165420 – 1623Sequence analysisAdd BLAST1604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1278 ↔ 1293PROSITE-ProRule annotation
Disulfide bondi1296 ↔ 1308PROSITE-ProRule annotation
Disulfide bondi1303 ↔ 1321PROSITE-ProRule annotation
Disulfide bondi1315 ↔ 1330PROSITE-ProRule annotation
Disulfide bondi1334 ↔ 1346PROSITE-ProRule annotation
Disulfide bondi1341 ↔ 1359PROSITE-ProRule annotation
Disulfide bondi1353 ↔ 1368PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati63 – 107LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati108 – 150LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati151 – 194LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati195 – 237LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati238 – 278LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini293 – 332EGF-likeInterPro annotationAdd BLAST40
Repeati380 – 422LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati423 – 465LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati466 – 509LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati510 – 552LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati553 – 595LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini599 – 636EGF-likeInterPro annotationAdd BLAST38
Repeati683 – 725LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati726 – 768LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati769 – 811LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati812 – 848LDL-receptor class BPROSITE-ProRule annotationAdd BLAST37
Repeati852 – 894LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini901 – 939EGF-likeInterPro annotationAdd BLAST39
Repeati986 – 1029LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1035 – 1077LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1078 – 1122LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati1123 – 1160LDL-receptor class BPROSITE-ProRule annotationAdd BLAST38
Repeati1163 – 1179LDL-receptor class BPROSITE-ProRule annotationAdd BLAST17
Domaini1214 – 1258EGF-likeInterPro annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1465 – 1500DisorderedSequence analysisAdd BLAST36
Regioni1548 – 1623DisorderedSequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1473 – 1489PolarSequence analysisAdd BLAST17

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158990

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002489_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3CCH4

Identification of Orthologs from Complete Genome Data

More...
OMAi
TNCANGH

TreeFam database of animal gene trees

More...
TreeFami
TF315253

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 4 hits
4.10.400.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR000742, EGF-like_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00057, Ldl_recept_a, 3 hits
PF00058, Ldl_recept_b, 11 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 4 hits
SM00192, LDLa, 3 hits
SM00135, LY, 19 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57424, SSF57424, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 3 hits
PS51120, LDLRB, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H3CCH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVALRTLLL WSFCCLVRGV PLLLYANRRD LRLVDAAQEK ANATVVVGGL
60 70 80 90 100
EDAAAVDYVY SQGLIYWSDV SEEAIKRTVF NQSGAHSVQT VIPGLASPDG
110 120 130 140 150
LACDWLGSKL YWTDSETNRI EVAELDGSLR KVLFWQELDQ PRAIALDPER
160 170 180 190 200
GFMYWTDWGE IPKIERAGMD GTNRSMIIDT DIYWPNGLTL DYQQQKLYWA
210 220 230 240 250
DAKHSFIHRC DLDGSSREVV VKDDLPHPFA LTLYEDTLFW TDWNTHSIST
260 270 280 290 300
CSKHTGGEQR VVHANIFSPM DIHVFSGKRQ NTRGGASAVV SSPCRVDNGG
310 320 330 340 350
CSHLCLLSPL EPFYQCACPT GVQLLADGKS CRDGATQVLL LARRADLRRI
360 370 380 390 400
SLDTPDFTDI VLQVDDIRHA IAIDYDPVDG YIYWTDDVVK AIRRSRLDGS
410 420 430 440 450
DAQFVVTSQV NHPDGIAVDW IARNLYWTDT GTDRIEVTRL NGTMRKILIS
460 470 480 490 500
EDLDEPRAIV LDPVAGYMYW TDWGEVPKIE RADLDGMERL VMVNTSLGWP
510 520 530 540 550
NGLALDYQER KIYWGDAKTD KIEVMDMDGT GRRVLVEDKL PHIFGFTLLG
560 570 580 590 600
DFIYWTDWQR RSIERVHKHT AEREFIIDQL PDLMGLKAAN VHQASGFNPC
610 620 630 640 650
GDSNGGCSHL CLFKPRGVQC GCPIGLELIA DMKTCIVPEA FLLFSRHTDI
660 670 680 690 700
RRISLETNNN NNVAIPLTGV KEASALDFDV TDNRIYWTDI TLKTISRAFM
710 720 730 740 750
NGSALEHVVE FGLDYPEGMA VDWLGKNLYW ADTGTNRIEV AKLDGQHRQV
760 770 780 790 800
LVWKDLDSPR ALALDPAEGY MYWTEWGGKP KIDRAAMDGS GRITLVADVG
810 820 830 840 850
RANGLTIDYA ERRLYWTDLD TTLIESSNML GQEREVIADD LPHPFGLTQY
860 870 880 890 900
QDYIYWTDWS QRSIERANKT SGQNRTLIQG HLDYVMDILV FHSSRQGGWN
910 920 930 940 950
ACTSTNGHCS HLCLAVPVSS FVCGCPAHFS LNDDNKTCSA PTSFLLFSQK
960 970 980 990 1000
TAINRMVIDE QQSPDIILPI HSLRNVRAID YDPLDKQLYW IDSKQNVIRR
1010 1020 1030 1040 1050
AQEDGNQSVT VVSGLMGGPS QGIQLYDLSI DIYSRFIYWT SEVTNAINVT
1060 1070 1080 1090 1100
RTDGSRVGVV LRGEQDKPRA IVVNPERGYM YFTNLLERSP KIERAALDGT
1110 1120 1130 1140 1150
EREVLFFSGL GKPVALAIDN ELGRLFWRWT RTCRRTSTSS RANRIVIADS
1160 1170 1180 1190 1200
NILQPVGLTV FGSHLYWIDK QQQMIERIDK TTREGRTKVQ ARVPYLSDIH
1210 1220 1230 1240 1250
AVNELDVREY SKHPCTWDNG GCSHICIVKG DGTTRCSCPV HLVLLQNELS
1260 1270 1280 1290 1300
CGDPPTCSPE QFSCLSGEVD CIPRAWRCDG FAECDDSSDE EDCPVCSKAE
1310 1320 1330 1340 1350
FQCDSRQCID LGLRCNGEVN CQDRSDENKC EVRCPPDQFT CTNGQCIGKH
1360 1370 1380 1390 1400
KKCDHNMDCT DNSDEIGCYP TEEPPPPPNS TIGSIVGVVM TLFVVGAAYF
1410 1420 1430 1440 1450
VCQRVLCPQM KDDGETVTND FVVHGPSSVP LGYVPHQGSL TSSLPGMSRG
1460 1470 1480 1490 1500
KSVIGSLSIM GGSSGPPYDR AHVTGASSSS SSSTKGTYFP PILNPPPSPA
1510 1520 1530 1540 1550
TVRSQYTLEF GYSSNSPSTH RSYSYRPYTY RHFAPPTTPC STDVCDSDYT
1560 1570 1580 1590 1600
PGRRAPVKSS AGVKGYTSDL NYDSEPFPPP PTPRSQYLSA EENCESCPPS
1610 1620
PYTERSYSHH LYPPPPSPCT DSS
Length:1,623
Mass (Da):181,199
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE95FD33FBB205926
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000006094; ENSTNIP00000005946; ENSTNIG00000003359

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTNIT00000006094; ENSTNIP00000005946; ENSTNIG00000003359

Phylogenomic databases

GeneTreeiENSGT00940000158990
HOGENOMiCLU_002489_0_0_1
InParanoidiH3CCH4
OMAiTNCANGH
TreeFamiTF315253

Family and domain databases

CDDicd00112, LDLa, 3 hits
Gene3Di2.120.10.30, 4 hits
4.10.400.10, 3 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR000742, EGF-like_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF00057, Ldl_recept_a, 3 hits
PF00058, Ldl_recept_b, 11 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 4 hits
SM00192, LDLa, 3 hits
SM00135, LY, 19 hits
SUPFAMiSSF57424, SSF57424, 3 hits
PROSITEiView protein in PROSITE
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 3 hits
PS51120, LDLRB, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3CCH4_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3CCH4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 7, 2021
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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