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Entry version 44 (02 Jun 2021)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Cortactin binding protein 2

Gene
N/A
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cortactin binding protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini567 – 754ANK_REP_REGIONInterPro annotationAdd BLAST188
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati567 – 599ANKPROSITE-ProRule annotationAdd BLAST33
Repeati600 – 632ANKPROSITE-ProRule annotationAdd BLAST33
Repeati633 – 665ANKPROSITE-ProRule annotationAdd BLAST33
Repeati666 – 692ANKPROSITE-ProRule annotationAdd BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni99 – 120DisorderedSequence analysisAdd BLAST22
Regioni145 – 207DisorderedSequence analysisAdd BLAST63
Regioni227 – 406DisorderedSequence analysisAdd BLAST180
Regioni417 – 436DisorderedSequence analysisAdd BLAST20
Regioni447 – 479DisorderedSequence analysisAdd BLAST33
Regioni525 – 551DisorderedSequence analysisAdd BLAST27
Regioni1249 – 1304DisorderedSequence analysisAdd BLAST56
Regioni1356 – 1477DisorderedSequence analysisAdd BLAST122

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili11 – 50Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi176 – 190Polar residuesSequence analysisAdd BLAST15
Compositional biasi227 – 247Polar residuesSequence analysisAdd BLAST21
Compositional biasi266 – 311Polar residuesSequence analysisAdd BLAST46
Compositional biasi355 – 379Pro residuesSequence analysisAdd BLAST25
Compositional biasi1287 – 1302Polar residuesSequence analysisAdd BLAST16
Compositional biasi1374 – 1396Polar residuesSequence analysisAdd BLAST23
Compositional biasi1404 – 1466Polar residuesSequence analysisAdd BLAST63

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158293

Identification of Orthologs from Complete Genome Data

More...
OMAi
AYQIAAC

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H3C1Z5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RRQIRSCVVV IDRAEQMCGF FQLEMEKLQL QSLEQEHRKL TAQLKDEREK
60 70 80 90 100
NKHIVMMLVR ECKQLATRVV EESQRFDELQ ARLDEESRAS GRLQEELAAE
110 120 130 140 150
RQRGQQMEAK MEKQLSEFDT EREQLRARLG REEAESLSLR QQVEQLRTEP
160 170 180 190 200
GDGKDGAPAA AAVTPPKPEA FTSVSVATEP VGSRTASCQT DPPPAEAEVP
210 220 230 240 250
RKNPLTIPVK PTPANYVGLS LPKTTGRGII HSSSGGLAQT ENGSEGQAPH
260 270 280 290 300
GLPSGVSPRV QAARYKFQEQ DQNGTASQSP PARDLSPTNR DNFAAKQQAR
310 320 330 340 350
HTVTQVLSRF TSPPAGGAGP LRPGLPHSAS EGGPFPGRLG HPIGLKSPTV
360 370 380 390 400
GRIDRGNPPP IPPKKPGLSQ TPSPPHPPIK VVGDSSRTPA AGLKPATPQL
410 420 430 440 450
PPKPALDLVP ALTASQVGSC SSCRSPGPGR APPPAAACAE CPPVISSTLS
460 470 480 490 500
SPSSINPPST SPSISAPSSR SSRSSAGSPL AAASGWCPSV VSSLGGGGPA
510 520 530 540 550
ALDSGRPLLS QAASQGNVTL LSKLLNQPDP TTTSTSTAST SVNTSSATAV
560 570 580 590 600
ENKPDRLDRN HHHYNHNHTS ALFAAAQNGH TERVKLLLSS GSPADVSHEN
610 620 630 640 650
GFTPLHLAAA YGNSSCVEEL LAAGAAVDAP TADGQTPLLL ACEAGRLDCV
660 670 680 690 700
RVLLTAGADR SRTTEDGCTS LHAAVRSGHA DTLRLLLGHP AQGDPAVTPD
710 720 730 740 750
PPAGLLNQAN GDGWTAAHMA AALGLKECLG VLCSHREQDI SRRDKCNRTP
760 770 780 790 800
HDLATDDCKD LLENLDVYQA LVCLQRSGGG PGRSLRLEEP SGTAANQLVL
810 820 830 840 850
GRVLVDRSMR WAQLSTALNQ VFASYLQTVC ADASAVRGET TRLPLGLGPG
860 870 880 890 900
SISTILIGDT ELLPGQELPL SPWDLVRKPL SQSISIRIKG LFDSCLDELA
910 920 930 940 950
LEYLFPLPLL CNYVRLVEQY GNLIFHGLEG SCQEDMADAV ACCIKSKQEA
960 970 980 990 1000
EGLGCDVVRV EVDESLTKEQ LLETFIDCGF LVPTAAASGG AARCVVVLLE
1010 1020 1030 1040 1050
GLEKASSLTG LLGDLCHSLD TRDSSSPLLL NTGPHHFCDG SFLIATLSKP
1060 1070 1080 1090 1100
RLQGSELRLQ QHFRWVTLRW DQEPLHGLLG RQLRRRLLHQ MGSGIWSPDG
1110 1120 1130 1140 1150
VMERSVLWVS QVWQQLNACL SRLGTHEALL GPQLFLSCPV VSNNTQAVVR
1160 1170 1180 1190 1200
WLARLWNAVV VPRVEEAIIA RVTTKGSAAH TPSSPPQRPS LSNCGLSAGQ
1210 1220 1230 1240 1250
QAVVKAALSI LVHKAVLPGC PLRRQEMDKY LLEFRGGLFP LSGISSYRGS
1260 1270 1280 1290 1300
AGVGGRRGRD SSKLRRSNTS PRKKGGSTLK WSCGGSFREG SKSSTDVSFT
1310 1320 1330 1340 1350
ANGKDQREPI GLSVFSDDET DLIRELQTIC SSKSEPDISK ILQAKDELVL
1360 1370 1380 1390 1400
FSSARAKATP DRDAEREPAS VQRLQTPGVR QSCSSSGGQT AVPNRDRRSS
1410 1420 1430 1440 1450
PRARSQLPVP SSRGHQPRGS AASTSNGSPV RNQTPPTRGR ISSRSKPMPP
1460 1470
SSSSSSSSSQ TQEDIWILNR DVHDSNK
Length:1,477
Mass (Da):157,491
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB745F5CA5D01941
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3DF60H3DF60_TETNG
Cortactin-binding protein 2
1,597Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000000262; ENSTNIP00000002262; ENSTNIG00000016064

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTNIT00000000262; ENSTNIP00000002262; ENSTNIG00000016064

Phylogenomic databases

GeneTreeiENSGT00940000158293
OMAiAYQIAAC

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3C1Z5_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3C1Z5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 2, 2021
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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