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Entry version 40 (05 Jun 2019)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)

Gene
N/A
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini642 – 831SEC7InterPro annotationAdd BLAST190

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni177 – 269DisorderedSequence analysisAdd BLAST93
Regioni333 – 363DisorderedSequence analysisAdd BLAST31
Regioni585 – 637DisorderedSequence analysisAdd BLAST53
Regioni1515 – 1562DisorderedSequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi177 – 191PolyampholyteSequence analysisAdd BLAST15
Compositional biasi192 – 213PolarSequence analysisAdd BLAST22
Compositional biasi333 – 356PolarSequence analysisAdd BLAST24
Compositional biasi1515 – 1556PolarSequence analysisAdd BLAST42

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0929 Eukaryota
COG5307 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157108

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00171 Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
IPR032691 Sec7_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF01369 Sec7, 1 hit
PF12783 Sec7_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00222 Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF48425 SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50190 SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

H3C134-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EEIKEESKKL SPTSGDAKSS SSTLPPIKSK ANFIEADKYF LPFELACQSK
60 70 80 90 100
CPRIVITSLD CLQKLIAYGH LTGSAPDSTA PGKKLIDRII ETICACFQGP
110 120 130 140 150
QTDEGVQLQI IKALLTAVTS QHIEIHEGTV LQAVRTCYNI YLASKNLINQ
160 170 180 190 200
TTAKATLTQM LNVIFARMEN QALQEAKQLE RERHRQHSPV TQHTDTESPT
210 220 230 240 250
LQTHSNPPNR QEGRGEQAEQ EEQGPVYENP DPENGSHYCV PENEQTEADQ
260 270 280 290 300
AQTARETVED EDEEAPNYEE KAQEIVQSIL QDVVNTVAGA EAEPEPAEAA
310 320 330 340 350
TDGVQNCIED ESTLGSDGEH VHANGIPGTP ISATFTPSLP DDRLSVSSND
360 370 380 390 400
TQESGVAPGQ PPGAKFSHIL QKDAFLVFRS LCKLSMKPLS DGPPDPKSHE
410 420 430 440 450
LRSKVLSLQL LLSILQNAGP IFKTNEMFIN AIKQYLCVAL SKNGVSSVPE
460 470 480 490 500
VFELSLSIFL TLLSHFKTHL KMQIEVFFKE IFLYILETST SSYEHKWMVI
510 520 530 540 550
QTLTRICADA QSVVDIYVNY DCDLNAANIF ERLVNDLSKI AQGRAGHELG
560 570 580 590 600
TTPLQELTLR KKGLECLVSI LKCMVEWSKD QYVNPNSQTS LGQEKPSEQE
610 620 630 640 650
NTDTKAPETI NRYGSINSLD STASSGIGSY STQMSGTDNP EQFEVLKQQK
660 670 680 690 700
EIIEQGIDLF NKKPKRGIQY LQEQGMLGTT PEDLAQFLHQ EERLDSTQVG
710 720 730 740 750
EFLGDNDRFN KEVMYAYVDQ MDFQGKDFVS ALRMFLEGFR LPGEAQKIDR
760 770 780 790 800
LMEKFAARYL ECNQGQTLFA SADTAYVLAY SIIMLTTDLH SPQVKNKMTK
810 820 830 840 850
EQYIKMNRGI NDSKDLPEEY LSAIYDEIAG KKIAMKETKE LTMKSNKQSV
860 870 880 890 900
ASEKQRRLLY NVEMEQMAKT AKALMEAVSH VQAPFTSATH LEHVRPMFKL
910 920 930 940 950
AWTPFLAAFS VGLQDCDDTE VASLCLEGIR CAIRIACIFS IQLERDAYVQ
960 970 980 990 1000
ALARFTLLTA SSGITEMKQK NIDTIKTLIT VAHTDGNYLG NSWHEIMKCI
1010 1020 1030 1040 1050
SQLELAQLIG TGVKARYISG TVRGKEGFIT STKEQNNDEY LGLVGGTVDR
1060 1070 1080 1090 1100
KQIASIQESI GETSSQSVVV AVDRIFTGST RLDGNAIVDF VRWLCAVSMD
1110 1120 1130 1140 1150
ELASPTHPRM FSLQKIVEIS YYNMGRIRLQ WSRIWEVIGD HFNKVGCNSN
1160 1170 1180 1190 1200
EDVAIFAVDS LRQLSMKFLE KGELANFRFQ KDFLRPFEHI MKKNRSPTIR
1210 1220 1230 1240 1250
DMVVRCIAQM VNSQAANIRS GWKNIFSVFH LAASDQDESI VELAFQTTGH
1260 1270 1280 1290 1300
IVTNVFEKHF AATIDSFQDA VKCLSEFACN ASFPDTSMEA IRLIRHCAKY
1310 1320 1330 1340 1350
VSDRPQAFKD YTSDDMNVAT EDRVWVRGWF PILFELSCII NRCKLDVRTR
1360 1370 1380 1390 1400
GLTVMFEVMK TYGHTFEKHW WQDLFRIVFR IFDNMKLPEQ QTEKAEWMTT
1410 1420 1430 1440 1450
TCNHALYAIC DVFTQYFEAL NDVLLDDILA QLYWCVQQDN EQLARSGTNC
1460 1470 1480 1490 1500
LENVVILNGE KFSPETWDKT CNCMLDIFIT TIPHALLTWR PAGAEGEHVT
1510 1520 1530 1540 1550
TQALSDKQLD SISQKSLDIQ SRSDDQHSIS SADRSTTDNH RQSHYSSGSG
1560 1570 1580 1590 1600
VGEDGSRSRT PTKVPEHRLF AALLIKCVVQ LELIQTIDNI VFFPATSKKE
1610 1620 1630 1640 1650
DAENFAAAQR DASHVADLPA ETQDQGMYRY LTSQQLFKLL DCLLESHRFA
1660 1670 1680 1690 1700
KAFNSNNEQR TLLWKAGFKG KSKPNLLKQE TSSLACGLRI LFRMYTDESR
1710 1720 1730 1740 1750
QDAWEEVQRR LLNVCSEAVA YFLALTSESH REAWTNLLLL FLTKVLKISD
1760 1770 1780 1790 1800
ERFKAHASRY YSLLCEIMQL DLIPELRAVL RKFYLRIGAV FHIAQLPEAE

PDRPAS
Length:1,806
Mass (Da):203,556
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7EB50B9FC0483579
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BWW0H3BWW0_TETNG
ADP-ribosylation factor guanine nuc...
1,811Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3C872H3C872_TETNG
ADP-ribosylation factor guanine nuc...
1,735Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3CXM2H3CXM2_TETNG
ADP-ribosylation factor guanine nuc...
1,745Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000000232; ENSTNIP00000001950; ENSTNIG00000010109

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTNIT00000000232; ENSTNIP00000001950; ENSTNIG00000010109

Phylogenomic databases

eggNOGiKOG0929 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00940000157108

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
IPR032691 Sec7_N
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF01369 Sec7, 1 hit
PF12783 Sec7_N, 1 hit
SMARTiView protein in SMART
SM00222 Sec7, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50190 SEC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3C134_TETNG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3C134
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 5, 2019
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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