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Protein
Submitted name:

Ryanodine receptor 2b (cardiac)

Gene
N/A
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Ryanodine receptor 2b (cardiac)Imported
OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
Taxonomic identifieri99883 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
Proteomesi
  • UP000007303 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4276 – 4299HelicalSequence analysisAdd BLAST24
Transmembranei4505 – 4526HelicalSequence analysisAdd BLAST22
Transmembranei4573 – 4592HelicalSequence analysisAdd BLAST20
Transmembranei4719 – 4744HelicalSequence analysisAdd BLAST26
Transmembranei4767 – 4789HelicalSequence analysisAdd BLAST23
Transmembranei4810 – 4828HelicalSequence analysisAdd BLAST19
Transmembranei4848 – 4871HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi99883.ENSTNIP00000000922

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 153MIRInterPro annotationAdd BLAST56
Domaini160 – 214MIRInterPro annotationAdd BLAST55
Domaini222 – 277MIRInterPro annotationAdd BLAST56
Domaini283 – 338MIRInterPro annotationAdd BLAST56
Domaini348 – 405MIRInterPro annotationAdd BLAST58
Domaini602 – 806B30.2/SPRYInterPro annotationAdd BLAST205
Domaini1023 – 1220B30.2/SPRYInterPro annotationAdd BLAST198
Domaini1377 – 1573B30.2/SPRYInterPro annotationAdd BLAST197
Domaini4039 – 4074EF-handInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili3345 – 3365Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
GeneTreeiENSGT00760000119152
InParanoidiH3BY57
OMAiTHEKWSL
OrthoDBiEOG091G00T0
TreeFamiTF315244

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR015925 Ryanodine_recept-rel
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PANTHERiPTHR13715 PTHR13715, 1 hit
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 1 hit
SSF47473 SSF47473, 1 hit
SSF48371 SSF48371, 7 hits
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50222 EF_HAND_2, 1 hit
PS50919 MIR, 5 hits

Sequencei

Sequence statusi: Complete.

H3BY57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFGEGDEE FQFLRTGDEV VLQSIFTLRG EHVKICLAAE GFGTRLCRLE
60 70 80 90 100
PIFNCKNVPP DVSVCGFVLA HCLSVRALQE MLTHTEHLAA ELAAGGGHRT
110 120 130 140 150
LLYGQAVLFL HSYSSMYLSC LSSSQSATDK LAFDVGLQED KEGETCWWIV
160 170 180 190 200
HPSSRQRSEG EKVRVGDDLI LVSMSSERYL HLSVGSGSDS SSSLSDSLSV
210 220 230 240 250
SASFQPTLWS VAPIYSGGGV AQGYLKGGDT FRLHHSHSDA CLTIASADQG
260 270 280 290 300
EEPQKVMHYE SGAVSSHARS LWRLEILHVV WSGSHTCWGQ PFRLCHMTTG
310 320 330 340 350
RYMGLTEERG LHLVERDKAD VRMSSFCFRS SKEKLDPGTR TNADGMGSPE
360 370 380 390 400
IKYGDSVCYV QHVDSGLWLT YRPVDAKSSR LRSTQRKAIL HSEGHMDDGL
410 420 430 440 450
RLSRCQREES HTARLIRSAS FLFTNFIRKQ DSCSQHGNQV SVCSPGEMMK
460 470 480 490 500
RSLQDLISYF YPTPETVEHE AKCHNMVVLK NRQNMFQEEG VIDLVLVCID
510 520 530 540 550
HLHQHIGTSQ CAEAAQEDSE EEWESCLDGF YKLLAALLRG NRANCARFSA
560 570 580 590 600
SIDWLISKLD WLEAATGVLE VLQCVLLESP EALNVVKENH IHSVISFLDK
610 620 630 640 650
HGLNHKVLEV LCALCVCHGV AVRYNQNLIC DKLLPERDLL LQTRLVNRVT
660 670 680 690 700
SMRPNIFLAF SEDSAQHRRW YYEVVVDHLD SFLTSEPTHL RVGWACTEGY
710 720 730 740 750
RPRLSGGEGW GGNGVGDDLC SYGFDGLHLW AGGVGRSVSS PFSHSLKDGD
760 770 780 790 800
VVSCCLDLSA PCISFRVNGL PVQGMLENFV AEGLLYPVVS FSAGVRIRFL
810 820 830 840 850
FGGQHGEFRY LPPPGFTACS DALLPKVKLK VEPCQKYILN REEGKHDLIG
860 870 880 890 900
PWIPTAPVVF IPAPVDISKV SLPPQLEDIQ EKLAENIHEL WAMDKIDLGW
910 920 930 940 950
TYGPVRDEAK KNDPSLAEFS KLSEHERNQN LHVAQDTLRT LLAFGFCIGF
960 970 980 990 1000
NEGHSNDRVR NKRLAAKYEQ PGGYRPAPVD LSQVLLSSEH QEVVNLLAEN
1010 1020 1030 1040 1050
DHNVWARERI AQGWTYGTQQ DVKAKRSPYL VPYSFLDEKT RRLSRDSVRE
1060 1070 1080 1090 1100
VVGTLLAFGY SLDPHSLKQA TLANQCLFSA EKCRVFRPDK SHAVSRGKWY
1110 1120 1130 1140 1150
FEFEAVTAGK MRVGWARPSC SPSRELGSDD RAFVFDGFEA QWYHQGAEPL
1160 1170 1180 1190 1200
GRSWQRGDVV GCLVDMDEST MMITLNGELL FDARGSELAA KDFDISDGLL
1210 1220 1230 1240 1250
PVASLGVNQV GRLNLGRCAA SLQYFTVCGQ QEGYQPFAVN MARDPALWIS
1260 1270 1280 1290 1300
WQQPQFSSIR PDDHIQVTRA SGSVGSLSSL RVSQRLFAHY NGSSQISFFR
1310 1320 1330 1340 1350
LSMHIECASV LISPAGGVLP VASSSLSPGR REQEEVDPDF EVLRKSALTF
1360 1370 1380 1390 1400
AGSRDELNHK DHNQEKTTRM KHRWSSLTTN VVVFDERHPY IDSSFFFSFL
1410 1420 1430 1440 1450
LKRNKPGLVS SNSSARLLED VVFDKENCDH LIQSSRYYYS ARVLPGQEPF
1460 1470 1480 1490 1500
NVWVGWVTSN FHSHDATFDP DGVHTVTVTL GDDSGKVQES IKRRVCYMVC
1510 1520 1530 1540 1550
AGEATGLAQS RRSSGLEIGC LIDTATGLLT FTSNGVEMST FFQVEACTKL
1560 1570 1580 1590 1600
FPAVFVRPTT TCMFQFEFGC IKNAMPLSAG LLRSQRCNVT PHCPPRIQVQ
1610 1620 1630 1640 1650
QLKPGSWTRL PSQAVKVVVD QPDAYGGWTI QCSEALQVMN LQIPDENRCV
1660 1670 1680 1690 1700
DILELSELDD LLTFHLHTLR LYCSLCSLGN TRVSHAICSY LDTSQFLHAI
1710 1720 1730 1740 1750
QNPHLPGLLR SVFYQLLIQV HLSSHTTACL MMNHEYIIPM AAKAGDTTLY
1760 1770 1780 1790 1800
PSSFTGHNGG NGITNSSHCT SLKPQMHFSS PSFVSNYALE GNYTAERNHG
1810 1820 1830 1840 1850
DSPEFPLDLL KNLTIQMLTE AVTALCQEVR DPVGGTIELL LVPLIKLAYS
1860 1870 1880 1890 1900
LLVMGVLEDE DLGKVLRLLD SEVSFTNSQS SMDEEKEDEK DDEKEHSLHH
1910 1920 1930 1940 1950
HQKDSHPKIG LLQIKLPEAV KLELCHLLSY LCDCQMRQRV EAVAAFSDTF
1960 1970 1980 1990 2000
VCQLQENQRF RYNEVMQALN MSAALTARKT KEFRSPPREQ INMLLSFRDD
2010 2020 2030 2040 2050
EVSCPCPVQI QELLHNFHHL FKTHCGIESE SDGEDEEAAE SVRTQILSQV
2060 2070 2080 2090 2100
AKVIGIKKKP LEVDASKPVA SKTLKHLVSK TLVHWSQEKM QDPELVRAVF
2110 2120 2130 2140 2150
SLLHCQYQGL GGQMAGPLSR TYTISHTSVD DTMALLSSLS QIRSLLCVRM
2160 2170 2180 2190 2200
GKEEEKLMIR KLGDIINNKV FYQHPDLMRT LGMHETVMEV MVNVLGEGES
2210 2220 2230 2240 2250
KEIAFPKMVA SCCRFLCYFC RISQHNQGAL FDHLSYLLEN ASVGLASPSM
2260 2270 2280 2290 2300
RGATPLDVAA ASVMDNNELA LALTESNLQK VIHYLASCGL KSCPMLVAKG
2310 2320 2330 2340 2350
YPDIGWNPVE GERYLDFLRF AVFCNGESVE ENAYMVLRLL IRRPECFGPA
2360 2370 2380 2390 2400
LQGDGGNGLL AAVREAIRIS DDPSMDGPSG PHQSTRSIDV IQDNDDDLIH
2410 2420 2430 2440 2450
MGHAMVTFYS ALIDLLGRCA PEMHLIEGGK GEALRVRAIL RSLVPVHDLE
2460 2470 2480 2490 2500
GVISSSFCLP SVTKDGGVVE PDLSAVFCPD HKAAMVLFLD RVYGIQNQSF
2510 2520 2530 2540 2550
FLHLIEVGFL PDLQAAVSLD TVDLASTDMA LALNRYLCAS VLPLLSKCSA
2560 2570 2580 2590 2600
LFCDLEDHVL LVDSLIQAIY SLSHALSLTK AQRDTIEDCL LALCSKLQPS
2610 2620 2630 2640 2650
LMQPLLRRLV FDVPHLPEHN KLALKLLTSH YEQRWKYYSM VGEPGDHSLA
2660 2670 2680 2690 2700
SEEELHLSRK LFWSVFKDLN KKPYEPQLFR LCVQCLAAVA KALPPDHTDA
2710 2720 2730 2740 2750
GCTSAMEGKA SADEQFDPQP IDTSNVSVPE RLEFIVNKYA EHTHEKWSLD
2760 2770 2780 2790 2800
KFANGWVHGE QLCESSKVHP LLKPYRTLAE KEKEAYRCAI KETIKTMLAF
2810 2820 2830 2840 2850
GWSIERTKEA DAHSVHTCAR RVSQSGQQLS FEGTSTFSPK PTDVSTITLS
2860 2870 2880 2890 2900
WDQCAMAEQL AENYHSTWAK RKKLELQGRG GGGHSMVVPY DALTAREKTK
2910 2920 2930 2940 2950
FRERAQDVLK FLHLNGYTVW RDRRTVEMDF PAVANCFGST LLMQFLSHTE
2960 2970 2980 2990 3000
NTQEHMLEME VMQARGQTSK GERTQLRQPV QVFHKVILPL LEEYVRTHCL
3010 3020 3030 3040 3050
YFLSSMSLSG KRGHASNKEK EMIASLFCKL AALIRHRMSL FGNEASAVSN
3060 3070 3080 3090 3100
CLCTLAQALD ARTLMNSASE SVRSSLDSFF ESSAADLEMT VENLCVSVAR
3110 3120 3130 3140 3150
LSQSRSQHAR GVARVLSYTS VVLLPTLTSL FQHLGLQNYG GDLLVGTIQV
3160 3170 3180 3190 3200
SCYKILNSLY SLGTTSSIYM EGQRPAAGAC LAALAATFPV CFLEPDLNQN
3210 3220 3230 3240 3250
NPYSIYNTAS ALEKEELGLP DHAGDMCPLL PSLEQALGDV KQLAAAGAGA
3260 3270 3280 3290 3300
RQSQYIHVTE VVLPMLCSYM SLWWSWGPEG QPNSPLCTTV TPQHASDLLG
3310 3320 3330 3340 3350
HVLRIIHNHV GTSQADWMKR MAVHCLSITC HAHPELLKTH FLPLMEKLKK
3360 3370 3380 3390 3400
RAEGVLLEEE RMKADAGDSS EAELEIQQKF MVLVADLYAF YPLLIPFVDS
3410 3420 3430 3440 3450
NRARWLKEST PEAEQLFIMV AEVFTFWAKS HNFKWEEQNY VVQNEINSLL
3460 3470 3480 3490 3500
FLVKSNKLSK FFNFQLNHEK RKVKKKGDRY STHTSLVVAS LKRLLPVGLR
3510 3520 3530 3540 3550
NCLLSDRSLI TLAKNGFTQK DTEDEIRQHI FSAFTLLQTQ DHSFLNDEVN
3560 3570 3580 3590 3600
DAERGGQRGK TADVQKAVDR VLNMGRVLCY LDQVEHPQRN RKTARHKILS
3610 3620 3630 3640 3650
KQRKRAVVAC LRMAPLYNLP RHRAVNLFLQ GYNKTWISTE DHSFEEKLVE
3660 3670 3680 3690 3700
DLALSGGVAE NDTVDGIKAI DPLLQLITLF SQTALMESSK LENGRLYQSY
3710 3720 3730 3740 3750
AAIMAKSCQR DDDGDGKEQE LESFEEKELE KQKLLFRQAR LHRRGASEMV
3760 3770 3780 3790 3800
LQIISASRGL MGSVIAPTLK LGIALLSGGN AAVQQKMLVY LRERRDVGFF
3810 3820 3830 3840 3850
QSMAGLMLSC SVLDLSAFER QNKAEGLGMA MDESSGPLFS PADKVMPDKD
3860 3870 3880 3890 3900
VTCDLFRFLQ LLCEGHNSEF QNYLRTQAGN NTTVNIVIST VDYLLRLQES
3910 3920 3930 3940 3950
VSDFFWYYSG KAAIDVHGQH NFSKAIEVSK QVFNTLTEYI QGPCAGNQES
3960 3970 3980 3990 4000
LAHSRLWDAV IGFLHVFAHM QMKLPQDSRQ IDLLKELLDL QKDMVVFLLS
4010 4020 4030 4040 4050
MLEGNIVNGT IGKQMVDMLV ESSGNVQMIL RFFDMFLKLK DFTSSDAFQA
4060 4070 4080 4090 4100
YDPDFKGCVS RKDFQKAMEG CKRFSQAETH FLMSCMGPDD REKVDYEAFV
4110 4120 4130 4140 4150
DGFHEPAQDI GFSIAVLLTN LSEHMPNDSR LRTFLEVAES VLTYFQPFLG
4160 4170 4180 4190 4200
RIEILGSGKR IERVYFGISA SSRTQWEKPQ VKESKRQFVF DVVNESGDKE
4210 4220 4230 4240 4250
KMEMFVNFCE DTIFEMQLAA QLSGSGVEER HVEASPEEKG DTNGLDNKGI
4260 4270 4280 4290 4300
GVMCQWLVLT SVLSVKALMK MSVKDVLVSA VVFLKFVLMA QFRCVLIVVR
4310 4320 4330 4340 4350
SIWYVLHRAF LSGELIEGAK RARISEMLGG ILEPTLDEVM GGPRGTRLRK
4360 4370 4380 4390 4400
GSSSLTLQKE LSGSRLAQTM ASTRDMHVLS DIFGLTVKKE GSGYRLISKD
4410 4420 4430 4440 4450
LTDSLTDLFT PACRGATCLD HFCAILTLFS EPQTHIHQEE KTEEKGADGK
4460 4470 4480 4490 4500
QNKSDQNSEA ILKDPKWRAQ RLNPKSKEAE NQPSALWEMV STHNKSMLNY
4510 4520 4530 4540 4550
FARNFYNLRV LALFVAFAIN FILLFYKVAS SPAAQVEEKE MPSAYSAGDD
4560 4570 4580 4590 4600
AEEGTVCFVL EERSGYMEPS LRFLAVAHTI ISFFCIFGYY CLKVPLVIFK
4610 4620 4630 4640 4650
REKEVARKLE FDGLYVTKQP PEEDIKGQWD RLVVNTPSFP SNYWDKFVKR
4660 4670 4680 4690 4700
KVMDKYGEFY GCEKISDLLG LDQAALDCSS ERKGRKRLRR STVWSHLFSS
4710 4720 4730 4740 4750
IDVKYQVWKT GVVFTDNSFL YLAWYMAMSV LGHYNNFFFA AHLLDVAMGF
4760 4770 4780 4790 4800
KTLRTILSSV THNGKQLVLT VGLLAVVVYL YTVLAFNFFR KFYNKSEDKD
4810 4820 4830 4840 4850
ARDMKCNDML TCYMFHMYVG VRAGGGIGDE IEDPAGDEFE VERIVFDITF
4860 4870 4880 4890 4900
FFFVIVILLA IIQGLIIDAF GELRDQQEQV KEDMETKCFI CGIGSEYFDK
4910 4920 4930 4940 4950
VPHGFETHTL QEHNLANYLF FLMYLINKDE TEYTGQESYV WKMYQERSWE
4960
FFPVGDCFRK QYEGQLG
Length:4,967
Mass (Da):557,479
Last modified:April 18, 2012 - v1
Checksum:iACD09ADBE040C52C
GO

Genome annotation databases

EnsembliENSTNIT00000003255; ENSTNIP00000000922; ENSTNIG00000017023

Similar proteinsi

Entry informationi

Entry nameiH3BY57_TETNG
AccessioniPrimary (citable) accession number: H3BY57
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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