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Entry version 62 (10 Feb 2021)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Tenascin C

Gene
N/A
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tenascin CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007303 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrixARBA annotation, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500358080723 – 1783Sequence analysisAdd BLAST1761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi200 ↔ 210PROSITE-ProRule annotation
Disulfide bondi217 ↔ 226PROSITE-ProRule annotation
Disulfide bondi324 ↔ 334PROSITE-ProRule annotation
Disulfide bondi341 ↔ 350PROSITE-ProRule annotation
Disulfide bondi417 ↔ 427PROSITE-ProRule annotation
Disulfide bondi434 ↔ 443PROSITE-ProRule annotation
Disulfide bondi479 ↔ 489PROSITE-ProRule annotation
Disulfide bondi496 ↔ 505PROSITE-ProRule annotation
Disulfide bondi541 ↔ 551PROSITE-ProRule annotation
Disulfide bondi558 ↔ 567PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini196 – 227EGF-likeInterPro annotationAdd BLAST32
Domaini320 – 351EGF-likeInterPro annotationAdd BLAST32
Domaini413 – 444EGF-likeInterPro annotationAdd BLAST32
Domaini475 – 506EGF-likeInterPro annotationAdd BLAST32
Domaini537 – 568EGF-likeInterPro annotationAdd BLAST32
Domaini572 – 662Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini663 – 750Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini751 – 841Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini842 – 932Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini933 – 1021Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1023 – 1118Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1204 – 1293Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1294 – 1383Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1384 – 1470Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini1471 – 1559Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1557 – 1772Fibrinogen C-terminalInterPro annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili129 – 149Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155188

Identification of Orthologs from Complete Genome Data

More...
OMAi
QLTCPNA

TreeFam database of animal gene trees

More...
TreeFami
TF329915

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 10 hits
cd00087, FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742, EGF-like_dom
IPR041161, EGF_Tenascin
IPR036056, Fibrinogen-like_C
IPR002181, Fibrinogen_a/b/g_C_dom
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18720, EGF_Tenascin, 7 hits
PF00147, Fibrinogen_C, 1 hit
PF00041, fn3, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 12 hits
SM00186, FBG, 1 hit
SM00060, FN3, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 7 hits
SSF56496, SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 5 hits
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 5 hits
PS51406, FIBRINOGEN_C_2, 1 hit
PS50853, FN3, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H3BY37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTKTILLVC LSVSLLFQLS AAGLVRKIIR HRRETLMPKK SQENLTLPHP
60 70 80 90 100
DQPVVFNHVY NINVPSTSLC SVDLDLPGEP EVKHKTPLRG VQNMEHIEHT
110 120 130 140 150
EDGDNQIVFT HRITIPKQAC SCENQLLDVK SILNRLEMLE LELSSLREQC
160 170 180 190 200
SGGAGCCGAQ VAGEISTKPY CNGRGNWSSD TCSCLCEVGW KGQNCSEPDC
210 220 230 240 250
PGDCQDQGRC LNGRCECFEG FGGDDCSAEL CLLDCGDYGH CVSGVCLCEE
260 270 280 290 300
GFSGQDCSQT NCLNSCLGRG RCLEDECVCD EPWTGLDCSE LICPNDCYDR
310 320 330 340 350
GRCLNGTCEC EQGYAGEDCG DLSCPGLCSN RGVCLNGQCV CQSGYSGDDC
360 370 380 390 400
SKLTCPKNCN EKGHCFNGKC ICDPGREGED CSVLSCPDNC NDRGQCVDGA
410 420 430 440 450
CVCDAGYQGE DCGALSCPNN CLDRGNCVNG QCVCDKGYSG EDCSVKTCPK
460 470 480 490 500
KCMERGDCVD GKCMCFPGFK GKDCGEMTCP GDCSNQGRCE SGKCVCHKGY
510 520 530 540 550
TGEDCSLKTC PKNCHDRGYC IDGNCVCYEG FTGPDCSTLA CPSDCQNQGH
560 570 580 590 600
CKNGVCVCEE GFIGEDCSQV SPPKDLTVVE VTPETVDLSW DNEMRVSEYL
610 620 630 640 650
VKYVPTAPGG LELDMQVPGD QKKATILELE PGVEYLIRVY AVLNNKKSIP
660 670 680 690 700
VDARVALDLP KPDGLKFKSV RDTSVEVEWD PLDIPFDGWN LIFRNTKEED
710 720 730 740 750
GEILNSLGQP ETTFEQSGLG PGQEYEVKLE VVKNNKRGPP ASKSVITMID
760 770 780 790 800
SPNQVDIRDV TDTTALLTWL PPVAEVEEVS ISYGPSSNPA DRNVVELPST
810 820 830 840 850
ESQYHLGGLD PDTHYQVSLT AHKGDWSSKP VHESFLTELD APKNLKTAEI
860 870 880 890 900
TDESITLEWE NSRAQVDNYR IKYGPLSGGE HRELLFTPGA KDHTHAKITG
910 920 930 940 950
LRASTEYGMG VTAVKDERES LPTTTNAVTA LDSPKDLTVT KVTETTMLLE
960 970 980 990 1000
WRHPQAKLDS YRLVYVSADG HRREEVLPGD LKSYSLVDLS PGTLYTISIS
1010 1020 1030 1040 1050
AERGSRTSAP NTVSAFTEEE KPLVTSFTIS DVSWDSLQLS WEAPDGAFQA
1060 1070 1080 1090 1100
FLVKVTDAET GSEVQNHSVV AGARSFAISD LSATTWYRVS LYGLHRGALL
1110 1120 1130 1140 1150
GPVTADTITG SNVTAYPPLS FLFYSLNMQS QFSQYGLLSI LLLPVGLGLG
1160 1170 1180 1190 1200
TAWPGGSRVV HNMAWAQLGP AVCMLMAAET SSTFFLSESL HPKKTQTIPE
1210 1220 1230 1240 1250
AEPEIQALLV SAVTPGSFRL TWTAEEDALD TFVIMVSPAD DPGHPTELVL
1260 1270 1280 1290 1300
ASEQRSVAVT NLTEDTQYKI QMFGLRFGRR TKSVQESVRT DLAPPKGIRF
1310 1320 1330 1340 1350
SDVTDTSTTV HWGAPRVRVD SYQITYVPAH GGSAKTLTVD GSKSQTVLPN
1360 1370 1380 1390 1400
LTPGVTYEVT IVAVKGSRES LPASDSITTA LDKPRGLVAV NITDTGALLL
1410 1420 1430 1440 1450
WQPAIATIDG YVITYSADAV DPVMERVSGN VMEFQMSSLV PATRYTVKVF
1460 1470 1480 1490 1500
AARDLAKSAA TSTEFTTDVD TPTHLAASSI QTESAMLTWK APRASITGYI
1510 1520 1530 1540 1550
LSFEAVDGTV REVVLSPTAV SYNMAQLSAS TEYSVRLQAI AGPKRSRVVA
1560 1570 1580 1590 1600
AVFTTTGVQY RHPRDCSQVL LNGDGASGPY TIFLGGDENQ PLQVYCDMST
1610 1620 1630 1640 1650
DGGGWIVFLR RQSGKLDFFR NWKNYTSGFG DMNDEFWLGL SNLNKITAAA
1660 1670 1680 1690 1700
QYELRVDLRD KGETAFAQYD RFSVSEPRSR YKVHVGGYSG TAGDSMTYHH
1710 1720 1730 1740 1750
GRPFSTYDHD NDIAVTNCAL SYKGAFWYKN CHRVNLMGRY GDNSHSKGVN
1760 1770 1780
WFHWKGHEHS IEFAEMKLRP SNFRNLEGRR KRS
Length:1,783
Mass (Da):194,441
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46A7F37F8E1E048D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3CZ25H3CZ25_TETNG
Tenascin C
1,693Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTNIT00000003851; ENSTNIP00000000902; ENSTNIG00000010597

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTNIT00000003851; ENSTNIP00000000902; ENSTNIG00000010597

Phylogenomic databases

GeneTreeiENSGT00940000155188
OMAiQLTCPNA
TreeFamiTF329915

Family and domain databases

CDDicd00063, FN3, 10 hits
cd00087, FReD, 1 hit
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR041161, EGF_Tenascin
IPR036056, Fibrinogen-like_C
IPR002181, Fibrinogen_a/b/g_C_dom
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
PfamiView protein in Pfam
PF18720, EGF_Tenascin, 7 hits
PF00147, Fibrinogen_C, 1 hit
PF00041, fn3, 10 hits
SMARTiView protein in SMART
SM00181, EGF, 12 hits
SM00186, FBG, 1 hit
SM00060, FN3, 10 hits
SUPFAMiSSF49265, SSF49265, 7 hits
SSF56496, SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 5 hits
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 5 hits
PS51406, FIBRINOGEN_C_2, 1 hit
PS50853, FN3, 10 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3BY37_TETNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3BY37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: February 10, 2021
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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