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Protein
Submitted name:

Prostasin

Gene

PRSS8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
ProstasinImported
Gene namesi
Name:PRSS8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000052344.15
HGNCiHGNC:9491 PRSS8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000052344

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500841515430 – 107Sequence analysisAdd BLAST78

Proteomic databases

PeptideAtlasiH3BVC8
PRIDEiH3BVC8

Expressioni

Gene expression databases

BgeeiENSG00000052344 Expressed in 145 organ(s), highest expression level in body of stomach
ExpressionAtlasiH3BVC8 baseline and differential

Structurei

3D structure databases

SMRiH3BVC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 107Peptidase S1InterPro annotationAdd BLAST69

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00900000140825

Family and domain databases

InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H3BVC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQKGVLGPG QLGAVAILLY LGLLRSGTAP CGVAPQARIT GGSSAVAGQW
60 70 80 90 100
PWQVSITYEG VHVCGGSLVS EQWVLSAAHC FPSEHHKEAY EVKLGAHQLD

SYSEDAK
Length:107
Mass (Da):11,188
Last modified:October 5, 2016 - v8
Checksum:iE4CF1C0A22CC2E16
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q16651PRSS8_HUMAN
Prostasin
PRSS8
343Annotation score:
H3BUJ8H3BUJ8_HUMAN
Prostasin
PRSS8
195Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei107Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009088 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000567797; ENSP00000458056; ENSG00000052344
UCSCiuc059tlp.1 human

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009088 Genomic DNA No translation available.

3D structure databases

SMRiH3BVC8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH3BVC8
PRIDEiH3BVC8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000567797; ENSP00000458056; ENSG00000052344
UCSCiuc059tlp.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000052344.15
HGNCiHGNC:9491 PRSS8
OpenTargetsiENSG00000052344
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00900000140825

Miscellaneous databases

ChiTaRSiPRSS8 human

Gene expression databases

BgeeiENSG00000052344 Expressed in 145 organ(s), highest expression level in body of stomach
ExpressionAtlasiH3BVC8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH3BVC8_HUMAN
AccessioniPrimary (citable) accession number: H3BVC8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 42 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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