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Protein

E3 ubiquitin protein ligase

Gene

RNF40

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.UniRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotation, TransferaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin protein ligaseUniRule annotation (EC:2.3.2.27UniRule annotation)
Gene namesi
Name:RNF40Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103549.21
HGNCiHGNC:16867 RNF40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103549

PTM / Processingi

Proteomic databases

MaxQBiH3BUL6
PeptideAtlasiH3BUL6
PRIDEiH3BUL6

Expressioni

Gene expression databases

BgeeiENSG00000103549 Expressed in 179 organ(s), highest expression level in testis
ExpressionAtlasiH3BUL6 baseline and differential

Interactioni

Subunit structurei

Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH3BUL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili63 – 83Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the BRE1 family.UniRule annotation

Keywords - Domaini

Coiled coilUniRule annotation, Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiKOG0978 Eukaryota
ENOG410Y5C6 LUCA
GeneTreeiENSGT00390000002866

Family and domain databases

InterProiView protein in InterPro
IPR013956 E3_ubiquit_lig_Bre1
PANTHERiPTHR23163 PTHR23163, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.iShow all

H3BUL6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGPGNKRAA GDGGSGPPEK KLSREEKTTT TLIEPIRLGG ISSTEEMDLK
60 70 80 90 100
VLQFKNKKLA ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ
110 120
LDETVEALLR CHESQGELSS APEAPGTQE
Length:129
Mass (Da):14,378
Last modified:April 18, 2012 - v1
Checksum:i696B808F79B2EBE6
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O75150BRE1B_HUMAN
E3 ubiquitin-protein ligase BRE1B
RNF40 BRE1B, KIAA0661
1,001Annotation score:
H3BP71H3BP71_HUMAN
E3 ubiquitin protein ligase
RNF40
961Annotation score:
H3BS50H3BS50_HUMAN
E3 ubiquitin protein ligase
RNF40
174Annotation score:
I3L332I3L332_HUMAN
E3 ubiquitin protein ligase
RNF40
144Annotation score:
H3BQ99H3BQ99_HUMAN
E3 ubiquitin protein ligase
RNF40
111Annotation score:
A0A087WTK2A0A087WTK2_HUMAN
E3 ubiquitin protein ligase
RNF40
177Annotation score:
R4GN66R4GN66_HUMAN
E3 ubiquitin-protein ligase BRE1B
RNF40
14Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei129Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106886 Genomic DNA No translation available.
KF456181 Genomic DNA No translation available.
KF456183 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000566811; ENSP00000457697; ENSG00000103549
UCSCiuc059tia.1 human

Similar proteinsi

Entry informationi

Entry nameiH3BUL6_HUMAN
AccessioniPrimary (citable) accession number: H3BUL6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 12, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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