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UniProtKB - H3BUK9 (POTB2_HUMAN)
Protein
POTE ankyrin domain family member B2
Gene
POTEB2
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Maps to a duplicated region on chromosome 15; the gene is present in at least 3 almost identical copies.Curated
Enzyme and pathway databases
PathwayCommonsi | H3BUK9 |
SignaLinki | H3BUK9 |
Names & Taxonomyi
Protein namesi | Recommended name: POTE ankyrin domain family member B2 |
Gene namesi | Name:POTEB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:48327, POTEB2 |
neXtProti | NX_H3BUK9 |
VEuPathDBi | HostDB:ENSG00000230031 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 100996331 |
Miscellaneous databases
Pharosi | H3BUK9, Tdark |
Genetic variation databases
BioMutai | POTEB2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000423303 | 1 – 544 | POTE ankyrin domain family member B2Add BLAST | 544 |
Proteomic databases
MassIVEi | H3BUK9 |
PaxDbi | H3BUK9 |
PRIDEi | H3BUK9 |
ProteomicsDBi | 42961 |
PTM databases
iPTMneti | H3BUK9 |
PhosphoSitePlusi | H3BUK9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000230031, Expressed in testis and 7 other tissues |
Genevisiblei | H3BUK9, HS |
Organism-specific databases
HPAi | ENSG00000230031, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 3190427, 13 interactors 939060, 5 interactors |
IntActi | H3BUK9, 4 interactors |
STRINGi | 9606.ENSP00000456953 |
Miscellaneous databases
RNActi | H3BUK9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 135 – 167 | ANK 1Add BLAST | 33 | |
Repeati | 168 – 200 | ANK 2Add BLAST | 33 | |
Repeati | 201 – 233 | ANK 3Add BLAST | 33 | |
Repeati | 234 – 266 | ANK 4Add BLAST | 33 | |
Repeati | 267 – 299 | ANK 5Add BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 332 – 457 | DisorderedSequence analysisAdd BLAST | 126 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 341 – 356 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 366 – 387 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 410 – 441 | Basic and acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 442 – 457 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the POTE family.Curated
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00940000163068 |
HOGENOMi | CLU_000134_9_2_1 |
OMAi | NPGNTCD |
OrthoDBi | 711966at2759 |
PhylomeDBi | H3BUK9 |
TreeFami | TF337879 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR039497, CC144C-like_CC_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF14915, CCDC144C, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits |
i Sequence
Sequence statusi: Complete.
H3BUK9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVAEVCSMPA ASAVKKPFDL RSKMGKWCHH RFPCCRGSGT SNVGTSGDHD
60 70 80 90 100
DSFMKTLRSK MGKWCCHCFP CCRGSGKSNV GTWGDYDDSA FMEPRYHVRR
110 120 130 140 150
EDLDKLHRAA WWGKVPRKDL IVMLRDTDMN KRDKQKRTAL HLASANGNSE
160 170 180 190 200
VVQLLLDRRC QLNVLDNKKR TALIKAVQCQ EDECVLMLLE HGADGNIQDE
210 220 230 240 250
YGNTALHYAI YNEDKLMAKA LLLYGADIES KNKCGLTPLL LGVHEQKQEV
260 270 280 290 300
VKFLIKKKAN LNALDRYGRT ALILAVCCGS ASIVNLLLEQ NVDVSSQDLS
310 320 330 340 350
GQTAREYAVS SHHHVICELL SDYKEKQMLK ISSENSNPEQ DLKLTSEEES
360 370 380 390 400
QRLKVSENSQ PEKMSQEPEI NKDCDREVEE EIKKHGSNPV GLPENLTNGA
410 420 430 440 450
SAGNGDDGLI PQRKSRKPEN QQFPDTENEE YHSDEQNDTQ KQLSEEQNTG
460 470 480 490 500
ISQDEILTNK QKQIEVAEKE MNSELSLSHK KEEDLLRENS MLREEIAKLR
510 520 530 540
LELDETKHQN QLRENKILEE IESVKEKLLK TIQLNEEALT KTSI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC012414 Genomic DNA No translation available. |
CCDSi | CCDS59248.1 |
RefSeqi | NP_001264232.1, NM_001277303.1 NP_001264233.1, NM_001277304.1 |
Genome annotation databases
Ensembli | ENST00000454856.4; ENSP00000456953.1; ENSG00000230031.10 |
GeneIDi | 100287399 100996331 |
KEGGi | hsa:100287399 |
MANE-Selecti | ENST00000439682.2; ENSP00000457689.2; NM_001277304.2; NP_001264233.1 ENST00000454856.4; ENSP00000456953.1; NM_001277303.1; NP_001264232.1 |
UCSCi | uc031qqz.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC012414 Genomic DNA No translation available. |
CCDSi | CCDS59248.1 |
RefSeqi | NP_001264232.1, NM_001277303.1 NP_001264233.1, NM_001277304.1 |
3D structure databases
AlphaFoldDBi | H3BUK9 |
SMRi | H3BUK9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 3190427, 13 interactors 939060, 5 interactors |
IntActi | H3BUK9, 4 interactors |
STRINGi | 9606.ENSP00000456953 |
PTM databases
iPTMneti | H3BUK9 |
PhosphoSitePlusi | H3BUK9 |
Genetic variation databases
BioMutai | POTEB2 |
Proteomic databases
MassIVEi | H3BUK9 |
PaxDbi | H3BUK9 |
PRIDEi | H3BUK9 |
ProteomicsDBi | 42961 |
Protocols and materials databases
DNASUi | 100287399 |
Genome annotation databases
Ensembli | ENST00000454856.4; ENSP00000456953.1; ENSG00000230031.10 |
GeneIDi | 100287399 100996331 |
KEGGi | hsa:100287399 |
MANE-Selecti | ENST00000439682.2; ENSP00000457689.2; NM_001277304.2; NP_001264233.1 ENST00000454856.4; ENSP00000456953.1; NM_001277303.1; NP_001264232.1 |
UCSCi | uc031qqz.2, human |
Organism-specific databases
CTDi | 100287399 |
DisGeNETi | 100996331 |
GeneCardsi | POTEB2 |
HGNCi | HGNC:48327, POTEB2 |
HPAi | ENSG00000230031, Tissue enriched (testis) |
neXtProti | NX_H3BUK9 |
VEuPathDBi | HostDB:ENSG00000230031 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00940000163068 |
HOGENOMi | CLU_000134_9_2_1 |
OMAi | NPGNTCD |
OrthoDBi | 711966at2759 |
PhylomeDBi | H3BUK9 |
TreeFami | TF337879 |
Enzyme and pathway databases
PathwayCommonsi | H3BUK9 |
SignaLinki | H3BUK9 |
Miscellaneous databases
BioGRID-ORCSi | 100287399, 13 hits in 201 CRISPR screens 100996331, 6 hits in 564 CRISPR screens |
Pharosi | H3BUK9, Tdark |
PROi | PR:H3BUK9 |
RNActi | H3BUK9, protein |
Gene expression databases
Bgeei | ENSG00000230031, Expressed in testis and 7 other tissues |
Genevisiblei | H3BUK9, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR039497, CC144C-like_CC_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF14915, CCDC144C, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | POTB2_HUMAN | |
Accessioni | H3BUK9Primary (citable) accession number: H3BUK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2013 |
Last sequence update: | April 18, 2012 | |
Last modified: | May 25, 2022 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families