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UniProtKB - H3BUK9 (POTB2_HUMAN)

Entry version 76 (25 May 2022)
Sequence version 1 (18 Apr 2012)
Previous versions | rss
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Protein

POTE ankyrin domain family member B2

Gene

POTEB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Maps to a duplicated region on chromosome 15; the gene is present in at least 3 almost identical copies.Curated

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		H3BUK9

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		H3BUK9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
POTE ankyrin domain family member B2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POTEB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:48327, POTEB2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_H3BUK9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000230031

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		100996331

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		H3BUK9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POTEB2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004233031 – 544POTE ankyrin domain family member B2Add BLAST544

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		H3BUK9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		H3BUK9

PRoteomics IDEntifications database

More...PRIDEi		H3BUK9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		42961

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		H3BUK9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		H3BUK9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000230031, Expressed in testis and 7 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		H3BUK9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000230031, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		3190427, 13 interactors
939060, 5 interactors

Protein interaction database and analysis system

More...IntActi		H3BUK9, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000456953

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		H3BUK9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		H3BUK9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		H3BUK9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati135 – 167ANK 1Add BLAST33
Repeati168 – 200ANK 2Add BLAST33
Repeati201 – 233ANK 3Add BLAST33
Repeati234 – 266ANK 4Add BLAST33
Repeati267 – 299ANK 5Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni332 – 457DisorderedSequence analysisAdd BLAST126

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi341 – 356Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi366 – 387Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi410 – 441Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi442 – 457Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the POTE family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0676, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163068

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000134_9_2_1

Identification of Orthologs from Complete Genome Data

More...OMAi		NPGNTCD

Database of Orthologous Groups

More...OrthoDBi		711966at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		H3BUK9

TreeFam database of animal gene trees

More...TreeFami		TF337879

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR039497, CC144C-like_CC_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 2 hits
PF14915, CCDC144C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H3BUK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAEVCSMPA ASAVKKPFDL RSKMGKWCHH RFPCCRGSGT SNVGTSGDHD 
        60         70         80         90        100
DSFMKTLRSK MGKWCCHCFP CCRGSGKSNV GTWGDYDDSA FMEPRYHVRR 
       110        120        130        140        150
EDLDKLHRAA WWGKVPRKDL IVMLRDTDMN KRDKQKRTAL HLASANGNSE 
       160        170        180        190        200
VVQLLLDRRC QLNVLDNKKR TALIKAVQCQ EDECVLMLLE HGADGNIQDE 
       210        220        230        240        250
YGNTALHYAI YNEDKLMAKA LLLYGADIES KNKCGLTPLL LGVHEQKQEV 
       260        270        280        290        300
VKFLIKKKAN LNALDRYGRT ALILAVCCGS ASIVNLLLEQ NVDVSSQDLS 
       310        320        330        340        350
GQTAREYAVS SHHHVICELL SDYKEKQMLK ISSENSNPEQ DLKLTSEEES 
       360        370        380        390        400
QRLKVSENSQ PEKMSQEPEI NKDCDREVEE EIKKHGSNPV GLPENLTNGA 
       410        420        430        440        450
SAGNGDDGLI PQRKSRKPEN QQFPDTENEE YHSDEQNDTQ KQLSEEQNTG 
       460        470        480        490        500
ISQDEILTNK QKQIEVAEKE MNSELSLSHK KEEDLLRENS MLREEIAKLR 
       510        520        530        540 
LELDETKHQN QLRENKILEE IESVKEKLLK TIQLNEEALT KTSI
Length:544
Mass (Da):61,708
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F75ABBB59531FB9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC012414 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS59248.1

NCBI Reference Sequences

More...RefSeqi		NP_001264232.1, NM_001277303.1
NP_001264233.1, NM_001277304.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000454856.4; ENSP00000456953.1; ENSG00000230031.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100287399
100996331

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:100287399

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000439682.2; ENSP00000457689.2; NM_001277304.2; NP_001264233.1
ENST00000454856.4; ENSP00000456953.1; NM_001277303.1; NP_001264232.1

UCSC genome browser

More...UCSCi		uc031qqz.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012414 Genomic DNA No translation available.
CCDSiCCDS59248.1
RefSeqiNP_001264232.1, NM_001277303.1
NP_001264233.1, NM_001277304.1

3D structure databases

AlphaFoldDBiH3BUK9
SMRiH3BUK9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi3190427, 13 interactors
939060, 5 interactors
IntActiH3BUK9, 4 interactors
STRINGi9606.ENSP00000456953

PTM databases

iPTMnetiH3BUK9
PhosphoSitePlusiH3BUK9

Genetic variation databases

BioMutaiPOTEB2

Proteomic databases

MassIVEiH3BUK9
PaxDbiH3BUK9
PRIDEiH3BUK9
ProteomicsDBi42961

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		100287399

Genome annotation databases

EnsembliENST00000454856.4; ENSP00000456953.1; ENSG00000230031.10
GeneIDi100287399
100996331
KEGGihsa:100287399
MANE-SelectiENST00000439682.2; ENSP00000457689.2; NM_001277304.2; NP_001264233.1
ENST00000454856.4; ENSP00000456953.1; NM_001277303.1; NP_001264232.1
UCSCiuc031qqz.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		100287399
DisGeNETi100996331

GeneCards: human genes, protein and diseases

More...GeneCardsi		POTEB2
HGNCiHGNC:48327, POTEB2
HPAiENSG00000230031, Tissue enriched (testis)
neXtProtiNX_H3BUK9
VEuPathDBiHostDB:ENSG00000230031

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0676, Eukaryota
GeneTreeiENSGT00940000163068
HOGENOMiCLU_000134_9_2_1
OMAiNPGNTCD
OrthoDBi711966at2759
PhylomeDBiH3BUK9
TreeFamiTF337879

Enzyme and pathway databases

PathwayCommonsiH3BUK9
SignaLinkiH3BUK9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		100287399, 13 hits in 201 CRISPR screens
100996331, 6 hits in 564 CRISPR screens
PharosiH3BUK9, Tdark

Protein Ontology

More...PROi		PR:H3BUK9
RNActiH3BUK9, protein

Gene expression databases

BgeeiENSG00000230031, Expressed in testis and 7 other tissues
GenevisibleiH3BUK9, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR039497, CC144C-like_CC_dom
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF14915, CCDC144C, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOTB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3BUK9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: April 18, 2012
Last modified: May 25, 2022
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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