UniProtKB - H3BTZ2 (H3BTZ2_HUMAN)
Protein
Receptor protein serine/threonine kinase
Gene
ACVRL1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.11.30ARBA annotation
- ATP + L-threonyl-[receptor-protein] = ADP + H+ + O-phospho-L-threonyl-[receptor-protein]ARBA annotationEC:2.7.11.30ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- transmembrane receptor protein serine/threonine kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseARBA annotation, Transferase |
Ligand | ATP-bindingARBA annotation, ManganeseARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor protein serine/threonine kinaseARBA annotation (EC:2.7.11.30ARBA annotation) |
Gene namesi | Name:ACVRL1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:175, ACVRL1 |
VEuPathDBi | HostDB:ENSG00000139567.12 |
Subcellular locationi
Other locations
- membrane Source: InterPro
Expressioni
Gene expression databases
Bgeei | ENSG00000139567, Expressed in tendon of biceps brachii and 197 other tissues |
ExpressionAtlasi | H3BTZ2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 163 | Protein kinaseInterPro annotationAdd BLAST | 163 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000161446 |
HOGENOMi | CLU_1639235_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
H3BTZ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XSRNVLVKSN LQCCIADLGL AVMHSQGSDY LDIGNNPRVG TKRYMAPEVL
60 70 80 90 100
DEQIRTDCFE SYKWTDIWAF GLVLWEIARR TIVNGIVEDY RPPFYDVVPN
110 120 130 140 150
DPSFEDMKKV VCVDQQTPTI PNRLAADPVR PLLGLGWRGV VAHGWDFWAQ
160
ELVSEASASS HRY
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP37023 | ACVL1_HUMAN | Serine/threonine-protein kinase rec... | ACVRL1 ACVRLK1, ALK1 | 503 | Annotation score: | ||
G3V1W8 | G3V1W8_HUMAN | Serine/threonine-protein kinase rec... | ACVRL1 hCG_37967 | 517 | Annotation score: | ||
E7EN07 | E7EN07_HUMAN | Receptor protein serine/threonine k... | ACVRL1 | 329 | Annotation score: | ||
F8W0N2 | F8W0N2_HUMAN | Serine/threonine-protein kinase rec... | ACVRL1 | 159 | Annotation score: | ||
D9IPD9 | D9IPD9_HUMAN | Activin A receptor type II-like kin... | ACVRL1 | 89 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC025259 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000552678; ENSP00000457394; ENSG00000139567 |
UCSCi | uc058oer.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC025259 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | H3BTZ2 |
PRIDEi | H3BTZ2 |
ProteomicsDBi | 42781 |
Protocols and materials databases
Antibodypediai | 2055, 588 antibodies |
Genome annotation databases
Ensembli | ENST00000552678; ENSP00000457394; ENSG00000139567 |
UCSCi | uc058oer.1, human |
Organism-specific databases
HGNCi | HGNC:175, ACVRL1 |
OpenTargetsi | ENSG00000139567 |
VEuPathDBi | HostDB:ENSG00000139567.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161446 |
HOGENOMi | CLU_1639235_0_0_1 |
Miscellaneous databases
ChiTaRSi | ACVRL1, human |
Gene expression databases
Bgeei | ENSG00000139567, Expressed in tendon of biceps brachii and 197 other tissues |
ExpressionAtlasi | H3BTZ2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H3BTZ2_HUMAN | |
Accessioni | H3BTZ2Primary (citable) accession number: H3BTZ2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | February 10, 2021 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |