UniProtKB - H3BS09 (H3BS09_HUMAN)
Protein
Deubiquitinating enzyme CYLD
Gene
CYLD
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- thiol-dependent ubiquitin-specific protease activity Source: InterPro
GO - Biological processi
- innate immune response Source: UniProtKB-KW
- protein deubiquitination Source: InterPro
- ubiquitin-dependent protein catabolic process Source: InterPro
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Immunity, Innate immunityARBA annotation, Wnt signaling pathwayARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Deubiquitinating enzyme CYLDARBA annotationAlternative name(s): Ubiquitin carboxyl-terminal hydrolase CYLDARBA annotation Ubiquitin thioesterase CYLDARBA annotation Ubiquitin-specific-processing protease CYLDARBA annotation |
Gene namesi | Name:CYLDImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2584, CYLD |
VEuPathDBi | HostDB:ENSG00000083799.17 |
Subcellular locationi
Cytoskeleton
- cilium basal body ARBA annotation
- centrosome ARBA annotation
- spindle ARBA annotation
Plasma membrane
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Other locations
- perinuclear region ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
- spindle Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell projection Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membraneARBA annotation, Cell projectionARBA annotation, MembranePTM / Processingi
Keywords - PTMi
Ubl conjugationARBA annotationProteomic databases
MaxQBi | H3BS09 |
PeptideAtlasi | H3BS09 |
PRIDEi | H3BS09 |
ProteomicsDBi | 42221 |
Expressioni
Gene expression databases
Bgeei | ENSG00000083799, Expressed in caudate nucleus and 243 other tissues |
ExpressionAtlasi | H3BS09, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 153 – 198 | CAP-GlyInterPro annotationAdd BLAST | 46 | |
Domaini | 407 – 765 | USPInterPro annotationAdd BLAST | 359 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 313 – 348 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 325 – 348 | PolarSequence analysisAdd BLAST | 24 |
Phylogenomic databases
GeneTreei | ENSGT00390000018123 |
HOGENOMi | CLU_003910_0_0_1 |
Family and domain databases
Gene3Di | 2.30.30.190, 2 hits |
InterProi | View protein in InterPro IPR036859, CAP-Gly_dom_sf IPR000938, CAP-Gly_domain IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF01302, CAP_GLY, 1 hit PF00443, UCH, 1 hit |
SMARTi | View protein in SMART SM01052, CAP_GLY, 2 hits |
SUPFAMi | SSF54001, SSF54001, 1 hit SSF74924, SSF74924, 2 hits |
PROSITEi | View protein in PROSITE PS00845, CAP_GLY_1, 1 hit PS50245, CAP_GLY_2, 1 hit PS00972, USP_1, 1 hit PS50235, USP_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
H3BS09-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI
60 70 80 90 100
QDRSVGHSRI PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL
110 120 130 140 150
LAITNCEERF SLFKNRNRLS KGLQIDVGCP VKVQLRSGEE KFPGVVRFRG
160 170 180 190 200
PLLAERTVSG IFFGVELLEE GRGQGFTDGV YQGKQLFQCD EDCGVFVALD
210 220 230 240 250
KLELIEDDDT ALESDYAGPG DTMQVELPPL EINSRVSLKV GETIESGTVI
260 270 280 290 300
FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFAC VESTILLHIN
310 320 330 340 350
DIIPESVTQE RRPPKLAFMS RGVGDKGSSS HNKPKATGST SDPGNRNRSE
360 370 380 390 400
LFYTLNGSSV DSQPQSKSKN TWYIDEAFGG YLSEVVEENT PPKMEKEGLE
410 420 430 440 450
IMIGKKKGIQ GHYNSCYLDS TLFCLFAFSS VLDTVLLRPK EKNDVEYYSE
460 470 480 490 500
TQELLRTEIV NPLRIYGYVC ATKIMKLRKI LEKVEAASGF TSEEKDPEEF
510 520 530 540 550
LNILFHHILR VEPLLKIRSA GQKVQDCYFY QIFMEKNEKV GVPTIQQLLE
560 570 580 590 600
WSFINSNLKF AEAPSCLIIQ MPRFGKDFKL FKKIFPSLEL NITDLLEDTP
610 620 630 640 650
RQCRICGGLA MYECRECYDD PDISAGKIKQ FCKTCNTQVH LHPKRLNHKY
660 670 680 690 700
NPVSLPKDLP DWDWRHGCIP CQNMELFAVL CIETSHYVAF VKYGKDDSAW
710 720 730 740 750
LFFDSMADRD GGQNGFNIPQ VTPCPEVGEY LKMSLEDLHS LDSRRIQGCA
760 770
RRLLCDAYMC MYQSPTMSLY K
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9NQC7 | CYLD_HUMAN | Ubiquitin carboxyl-terminal hydrola... | CYLD CYLD1, KIAA0849, HSPC057 | 956 | Annotation score: | ||
J3KRR7 | J3KRR7_HUMAN | Deubiquitinating enzyme CYLD | CYLD | 910 | Annotation score: | ||
H3BSW9 | H3BSW9_HUMAN | Ubiquitin carboxyl-terminal hydrola... | CYLD | 304 | Annotation score: | ||
J3QKR2 | J3QKR2_HUMAN | Ubiquitin carboxyl-terminal hydrola... | CYLD | 104 | Annotation score: | ||
H3BPZ5 | H3BPZ5_HUMAN | Ubiquitin carboxyl-terminal hydrola... | CYLD | 33 | Annotation score: | ||
I3L117 | I3L117_HUMAN | Ubiquitin carboxyl-terminal hydrola... | CYLD | 66 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007728 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000568704; ENSP00000456488; ENSG00000083799 |
UCSCi | uc059uca.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007728 Genomic DNA No translation available. |
3D structure databases
SMRi | H3BS09 |
ModBasei | Search... |
Proteomic databases
MaxQBi | H3BS09 |
PeptideAtlasi | H3BS09 |
PRIDEi | H3BS09 |
ProteomicsDBi | 42221 |
Protocols and materials databases
Antibodypediai | 3193, 295 antibodies |
Genome annotation databases
Ensembli | ENST00000568704; ENSP00000456488; ENSG00000083799 |
UCSCi | uc059uca.1, human |
Organism-specific databases
HGNCi | HGNC:2584, CYLD |
OpenTargetsi | ENSG00000083799 |
VEuPathDBi | HostDB:ENSG00000083799.17 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000018123 |
HOGENOMi | CLU_003910_0_0_1 |
Miscellaneous databases
ChiTaRSi | CYLD, human |
Gene expression databases
Bgeei | ENSG00000083799, Expressed in caudate nucleus and 243 other tissues |
ExpressionAtlasi | H3BS09, baseline and differential |
Family and domain databases
Gene3Di | 2.30.30.190, 2 hits |
InterProi | View protein in InterPro IPR036859, CAP-Gly_dom_sf IPR000938, CAP-Gly_domain IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF01302, CAP_GLY, 1 hit PF00443, UCH, 1 hit |
SMARTi | View protein in SMART SM01052, CAP_GLY, 2 hits |
SUPFAMi | SSF54001, SSF54001, 1 hit SSF74924, SSF74924, 2 hits |
PROSITEi | View protein in PROSITE PS00845, CAP_GLY_1, 1 hit PS50245, CAP_GLY_2, 1 hit PS00972, USP_1, 1 hit PS50235, USP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H3BS09_HUMAN | |
Accessioni | H3BS09Primary (citable) accession number: H3BS09 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | February 10, 2021 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |