UniProtKB - H3BRS1 (H3BRS1_HUMAN)

BLAST

>tr|H3BRS1|H3BRS1_HUMAN Nuclear factor of-activated T-cells, cytoplasmic 3 (Fragment) OS=Homo sapiens OX=9606 GN=NFATC3 PE=1 SV=1
XLDDRRPITLCVCVRARVCDLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLS
PSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQITSISPNCHQELDAHEDDLQIND
PEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSE
LNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVTDENWL
SPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLNASV
HGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAILPGKLELCSDDQGSLSPARETSIDD
GLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPAHFGQCELKI
EVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNEKPINLQMFIGTADDRYLRPHAF
YQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGET
DIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGG
HEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAA
VQVHFYLCNGKRKKSQSQRFTYTPVLMKQEHREEIDLSSVPSLPVPHPAQTQRPSSDSGC
SHDSVLSGQRSLICSIPQTYASMVTSSHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPT
PPVGSSYQPMQTNVVYNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLSSIPFH
SSNSGSTGHLLAHTPHSVHTLPHLQSMGYHCSNTGQRSLSSPVADQITGQPSSQLQPITY
GPSHSGSATTASPAASHPLASSPLSGPPSPQLQPMPYQSPSSGTASSPSPATRMHSGQHS
TQAQSTGQGGLSAPSSLICHSLCDPASFPPDGATVSIKPEPEDREPNFATIGLQDITLDD
VNEIIGRDMSQISVSQGAGVSRQAPLPSPESLDLGRSDGL

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History
Entry version 39 (12 Sep 2018)
Sequence version 1 (11 Jul 2012)
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Protein

Submitted name:

Nuclear factor of-activated T-cells, cytoplasmic 3

Gene

NFATC3

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: InterPro
DNA-binding transcription factor activity Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Nuclear factor of-activated T-cells, cytoplasmic 3Imported
Gene namesⁱ	Name:NFATC3Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000072736.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7777 NFATC3

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000072736

OpenTargetsⁱ

ENSG00000072736

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	H3BRS1
PeptideAtlas More...PeptideAtlasⁱ	H3BRS1
PRIDEⁱ	H3BRS1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000072736 Expressed in 214 organ(s), highest expression level in leukocyte
ExpressionAtlasⁱ	H3BRS1 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	H3BRS1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	400 – 581	RHDInterPro annotationAdd BLAST		182

Phylogenomic databases

eggNOGⁱ	ENOG410IIAD Eukaryota ENOG4111EMW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074562

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 2.60.40.340, 1 hit
InterProⁱ	View protein in InterPro IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR002909 IPT_dom IPR008366 NFAT IPR008967 p53-like_TF_DNA-bd IPR032397 RHD_dimer IPR011539 RHD_DNA_bind_dom IPR037059 RHD_DNA_bind_dom_sf
PANTHERⁱ	PTHR12533 PTHR12533, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16179 RHD_dimer, 1 hit PF00554 RHD_DNA_bind, 1 hit
PRINTSⁱ	PR01789 NUCFACTORATC
SMARTⁱ	View protein in SMART SM00429 IPT, 1 hit
SUPFAMⁱ	SSF49417 SSF49417, 1 hit SSF81296 SSF81296, 1 hit
PROSITEⁱ	View protein in PROSITE PS50254 REL_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

H3BRS1-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
XLDDRRPITL CVCVRARVCD LEPDDCASIY IFNVDPPPST LTTPLCLPHH 
        60         70         80         90        100
GLPSHSSVLS PSFQLQSHKN YEGTCEIPES KYSPLGGPKP FECPSIQITS 
       110        120        130        140        150
ISPNCHQELD AHEDDLQIND PEREFLERPS RDHLYLPLEP SYRESSLSPS 
       160        170        180        190        200
PASSISSRSW FSDASSCESL SHIYDDVDSE LNEAAARFTL GSPLTSPGGS 
       210        220        230        240        250
PGGCPGEETW HQQYGLGHSL SPRQSPCHSP RSSVTDENWL SPRPASGPSS 
       260        270        280        290        300
RPTSPCGKRR HSSAEVCYAG SLSPHHSPVP SPGHSPRGSV TEDTWLNASV 
       310        320        330        340        350
HGGSGLGPAV FPFQYCVETD IPLKTRKTSE DQAAILPGKL ELCSDDQGSL 
       360        370        380        390        400
SPARETSIDD GLGSQYPLKK DSCGDQFLSV PSPFTWSKPK PGHTPIFRTS 
       410        420        430        440        450
SLPPLDWPLP AHFGQCELKI EVQPKTHHRA HYETEGSRGA VKASTGGHPV 
       460        470        480        490        500
VKLLGYNEKP INLQMFIGTA DDRYLRPHAF YQVHRITGKT VATASQEIII 
       510        520        530        540        550
ASTKVLEIPL LPENNMSASI DCAGILKLRN SDIELRKGET DIGRKNTRVR 
       560        570        580        590        600
LVFRVHIPQP SGKVLSLQIA SIPVECSQRS AQELPHIEKY SINSCSVNGG 
       610        620        630        640        650
HEMVVTGSNF LPESKIIFLE KGQDGRPQWE VEGKIIREKC QGAHIVLEVP 
       660        670        680        690        700
PYHNPAVTAA VQVHFYLCNG KRKKSQSQRF TYTPVLMKQE HREEIDLSSV 
       710        720        730        740        750
PSLPVPHPAQ TQRPSSDSGC SHDSVLSGQR SLICSIPQTY ASMVTSSHLP 
       760        770        780        790        800
QLQCRDESVS KEQHMIPSPI VHQPFQVTPT PPVGSSYQPM QTNVVYNGPT 
       810        820        830        840        850
CLPINAASSQ EFDSVLFQQD ATLSGLVNLG CQPLSSIPFH SSNSGSTGHL 
       860        870        880        890        900
LAHTPHSVHT LPHLQSMGYH CSNTGQRSLS SPVADQITGQ PSSQLQPITY 
       910        920        930        940        950
GPSHSGSATT ASPAASHPLA SSPLSGPPSP QLQPMPYQSP SSGTASSPSP 
       960        970        980        990       1000
ATRMHSGQHS TQAQSTGQGG LSAPSSLICH SLCDPASFPP DGATVSIKPE 
      1010       1020       1030       1040       1050
PEDREPNFAT IGLQDITLDD VNEIIGRDMS QISVSQGAGV SRQAPLPSPE 
      1060
SLDLGRSDGL

Length:1,060

Mass (Da):114,327

Last modified:July 11, 2012 - v1

Checksum:ⁱE5D34902CBDAEE33

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q12968	NFAC3_HUMAN	Nuclear factor of activated T-cells... Nuclear factor of activated T-cells, cytoplasmic 3, NF-ATc3, NFATc3 (NFATx) (T-cell transcription factor NFAT4, NF-AT4)	NFATC3 NFAT4	1,075	Annotation score:
I3L3K7	I3L3K7_HUMAN	Nuclear factor of-activated T-cells... Nuclear factor of-activated T-cells, cytoplasmic 3	NFATC3	1,047	Annotation score:
H3BR83	H3BR83_HUMAN	Nuclear factor of-activated T-cells... Nuclear factor of-activated T-cells, cytoplasmic 3	NFATC3	1,053	Annotation score:
H3BU30	H3BU30_HUMAN	Nuclear factor of-activated T-cells... Nuclear factor of-activated T-cells, cytoplasmic 3	NFATC3	167	Annotation score:
H3BRM3	H3BRM3_HUMAN	Nuclear factor of-activated T-cells... Nuclear factor of-activated T-cells, cytoplasmic 3	NFATC3	41	Annotation score:
F8VPH9	F8VPH9_HUMAN	Nuclear factor of-activated T-cells... Nuclear factor of-activated T-cells, cytoplasmic 3	NFATC3	38	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC020978 Genomic DNA No translation available. AC130462 Genomic DNA No translation available. KF456209 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC020978 Genomic DNA No translation available.
AC130462 Genomic DNA No translation available.
KF456209 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000570212; ENSP00000456379; ENSG00000072736
UCSC genome browser More...UCSCⁱ	uc059wdd.1 human

Protein	Similar proteins		Species	Score	Length	Source
H3BRS1	Nuclear factor of activated T-cells, cytoplasmic 3	)	HUMAN		1075	UniRef90_Q12968
Nuclear factor of activated T cells 3		SAIBB		1088
NFATC3 isoform 2		PANTR		1075
Nuclear factor of activated T-cells, cytoplasmic 3 isoform 1		MACMU		1075
Nuclear factor of activated T-cells, cytoplasmic 3 isoform 1		CALJA		1075
+153

Protein	Similar proteins		Species	Score	Length	Source
H3BRS1	Nuclear factor of activated T-cells, cytoplasmic 3		MOUSE		1075	UniRef50_P97305
Nuclear factor of activated T-cells, cytoplasmic 3	)	HUMAN		1075
Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b		RAT		1076
Nuclear factor of activated T-cells, cytoplasmic 3		CRIGR		1075
nuclear factor of activated T-cells, cytoplasmic 3		MESAU		414
+302

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC020978 Genomic DNA No translation available. AC130462 Genomic DNA No translation available. KF456209 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC020978 Genomic DNA No translation available.
AC130462 Genomic DNA No translation available.
KF456209 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	H3BRS1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQBⁱ	H3BRS1
PeptideAtlasⁱ	H3BRS1
PRIDEⁱ	H3BRS1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000570212; ENSP00000456379; ENSG00000072736
UCSCⁱ	uc059wdd.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000072736.18
HGNCⁱ	HGNC:7777 NFATC3
OpenTargetsⁱ	ENSG00000072736
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIAD Eukaryota ENOG4111EMW LUCA
GeneTreeⁱ	ENSGT00550000074562

Miscellaneous databases

ChiTaRSⁱ	NFATC3 human

ChiTaRSⁱ

NFATC3 human

Gene expression databases

Bgeeⁱ	ENSG00000072736 Expressed in 214 organ(s), highest expression level in leukocyte
ExpressionAtlasⁱ	H3BRS1 baseline and differential

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 2.60.40.340, 1 hit
InterProⁱ	View protein in InterPro IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR002909 IPT_dom IPR008366 NFAT IPR008967 p53-like_TF_DNA-bd IPR032397 RHD_dimer IPR011539 RHD_DNA_bind_dom IPR037059 RHD_DNA_bind_dom_sf
PANTHERⁱ	PTHR12533 PTHR12533, 1 hit
Pfamⁱ	View protein in Pfam PF16179 RHD_dimer, 1 hit PF00554 RHD_DNA_bind, 1 hit
PRINTSⁱ	PR01789 NUCFACTORATC
SMARTⁱ	View protein in SMART SM00429 IPT, 1 hit
SUPFAMⁱ	SSF49417 SSF49417, 1 hit SSF81296 SSF81296, 1 hit
PROSITEⁱ	View protein in PROSITE PS50254 REL_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H3BRS1_HUMAN
Accessionⁱ	H3BRS1Primary (citable) accession number: H3BRS1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 11, 2012
	Last sequence update:	July 11, 2012
	Last modified:	September 12, 2018
	This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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UniParc

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UniProtKB - H3BRS1 (H3BRS1_HUMAN)

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Nuclear factor of-activated T-cells, cytoplasmic 3

NFATC3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ