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Protein
Submitted name:

Nuclear factor of-activated T-cells, cytoplasmic 3

Gene

NFATC3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor of-activated T-cells, cytoplasmic 3Imported
Gene namesi
Name:NFATC3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000072736.18
HGNCiHGNC:7777 NFATC3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000072736

PTM / Processingi

Proteomic databases

MaxQBiH3BRS1
PeptideAtlasiH3BRS1
PRIDEiH3BRS1

Expressioni

Gene expression databases

BgeeiENSG00000072736 Expressed in 214 organ(s), highest expression level in leukocyte
ExpressionAtlasiH3BRS1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH3BRS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini400 – 581RHDInterPro annotationAdd BLAST182

Phylogenomic databases

eggNOGiENOG410IIAD Eukaryota
ENOG4111EMW LUCA
GeneTreeiENSGT00550000074562

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR008366 NFAT
IPR008967 p53-like_TF_DNA-bd
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR12533 PTHR12533, 1 hit
PfamiView protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR01789 NUCFACTORATC
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50254 REL_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

H3BRS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XLDDRRPITL CVCVRARVCD LEPDDCASIY IFNVDPPPST LTTPLCLPHH
60 70 80 90 100
GLPSHSSVLS PSFQLQSHKN YEGTCEIPES KYSPLGGPKP FECPSIQITS
110 120 130 140 150
ISPNCHQELD AHEDDLQIND PEREFLERPS RDHLYLPLEP SYRESSLSPS
160 170 180 190 200
PASSISSRSW FSDASSCESL SHIYDDVDSE LNEAAARFTL GSPLTSPGGS
210 220 230 240 250
PGGCPGEETW HQQYGLGHSL SPRQSPCHSP RSSVTDENWL SPRPASGPSS
260 270 280 290 300
RPTSPCGKRR HSSAEVCYAG SLSPHHSPVP SPGHSPRGSV TEDTWLNASV
310 320 330 340 350
HGGSGLGPAV FPFQYCVETD IPLKTRKTSE DQAAILPGKL ELCSDDQGSL
360 370 380 390 400
SPARETSIDD GLGSQYPLKK DSCGDQFLSV PSPFTWSKPK PGHTPIFRTS
410 420 430 440 450
SLPPLDWPLP AHFGQCELKI EVQPKTHHRA HYETEGSRGA VKASTGGHPV
460 470 480 490 500
VKLLGYNEKP INLQMFIGTA DDRYLRPHAF YQVHRITGKT VATASQEIII
510 520 530 540 550
ASTKVLEIPL LPENNMSASI DCAGILKLRN SDIELRKGET DIGRKNTRVR
560 570 580 590 600
LVFRVHIPQP SGKVLSLQIA SIPVECSQRS AQELPHIEKY SINSCSVNGG
610 620 630 640 650
HEMVVTGSNF LPESKIIFLE KGQDGRPQWE VEGKIIREKC QGAHIVLEVP
660 670 680 690 700
PYHNPAVTAA VQVHFYLCNG KRKKSQSQRF TYTPVLMKQE HREEIDLSSV
710 720 730 740 750
PSLPVPHPAQ TQRPSSDSGC SHDSVLSGQR SLICSIPQTY ASMVTSSHLP
760 770 780 790 800
QLQCRDESVS KEQHMIPSPI VHQPFQVTPT PPVGSSYQPM QTNVVYNGPT
810 820 830 840 850
CLPINAASSQ EFDSVLFQQD ATLSGLVNLG CQPLSSIPFH SSNSGSTGHL
860 870 880 890 900
LAHTPHSVHT LPHLQSMGYH CSNTGQRSLS SPVADQITGQ PSSQLQPITY
910 920 930 940 950
GPSHSGSATT ASPAASHPLA SSPLSGPPSP QLQPMPYQSP SSGTASSPSP
960 970 980 990 1000
ATRMHSGQHS TQAQSTGQGG LSAPSSLICH SLCDPASFPP DGATVSIKPE
1010 1020 1030 1040 1050
PEDREPNFAT IGLQDITLDD VNEIIGRDMS QISVSQGAGV SRQAPLPSPE
1060
SLDLGRSDGL
Length:1,060
Mass (Da):114,327
Last modified:July 11, 2012 - v1
Checksum:iE5D34902CBDAEE33
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q12968NFAC3_HUMAN
Nuclear factor of activated T-cells...
NFATC3 NFAT4
1,075Annotation score:
I3L3K7I3L3K7_HUMAN
Nuclear factor of-activated T-cells...
NFATC3
1,047Annotation score:
H3BR83H3BR83_HUMAN
Nuclear factor of-activated T-cells...
NFATC3
1,053Annotation score:
H3BU30H3BU30_HUMAN
Nuclear factor of-activated T-cells...
NFATC3
167Annotation score:
H3BRM3H3BRM3_HUMAN
Nuclear factor of-activated T-cells...
NFATC3
41Annotation score:
F8VPH9F8VPH9_HUMAN
Nuclear factor of-activated T-cells...
NFATC3
38Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020978 Genomic DNA No translation available.
AC130462 Genomic DNA No translation available.
KF456209 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000570212; ENSP00000456379; ENSG00000072736
UCSCiuc059wdd.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020978 Genomic DNA No translation available.
AC130462 Genomic DNA No translation available.
KF456209 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH3BRS1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH3BRS1
PeptideAtlasiH3BRS1
PRIDEiH3BRS1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000570212; ENSP00000456379; ENSG00000072736
UCSCiuc059wdd.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000072736.18
HGNCiHGNC:7777 NFATC3
OpenTargetsiENSG00000072736
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIAD Eukaryota
ENOG4111EMW LUCA
GeneTreeiENSGT00550000074562

Miscellaneous databases

ChiTaRSiNFATC3 human

Gene expression databases

BgeeiENSG00000072736 Expressed in 214 organ(s), highest expression level in leukocyte
ExpressionAtlasiH3BRS1 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR008366 NFAT
IPR008967 p53-like_TF_DNA-bd
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR12533 PTHR12533, 1 hit
PfamiView protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR01789 NUCFACTORATC
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50254 REL_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH3BRS1_HUMAN
AccessioniPrimary (citable) accession number: H3BRS1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: September 12, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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