UniProtKB - H3BRS1 (H3BRS1_HUMAN)
Protein
Submitted name:
Nuclear factor of-activated T-cells, cytoplasmic 3
Gene
NFATC3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Nuclear factor of-activated T-cells, cytoplasmic 3Imported |
Gene namesi | Name:NFATC3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000072736.18 |
HGNCi | HGNC:7777, NFATC3 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
PTM / Processingi
Proteomic databases
MaxQBi | H3BRS1 |
PeptideAtlasi | H3BRS1 |
PRIDEi | H3BRS1 |
ProteomicsDBi | 42148 |
Expressioni
Gene expression databases
Bgeei | ENSG00000072736, Expressed in leukocyte and 227 other tissues |
ExpressionAtlasi | H3BRS1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 400 – 581 | RHDInterPro annotationAdd BLAST | 182 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 109 – 132 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 188 – 292 | DisorderedSequence analysisAdd BLAST | 105 | |
Regioni | 346 – 365 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 696 – 724 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 866 – 1006 | DisorderedSequence analysisAdd BLAST | 141 | |
Regioni | 1032 – 1060 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 214 – 257 | PolarSequence analysisAdd BLAST | 44 | |
Compositional biasi | 704 – 724 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 866 – 919 | PolarSequence analysisAdd BLAST | 54 | |
Compositional biasi | 936 – 975 | PolarSequence analysisAdd BLAST | 40 |
Phylogenomic databases
GeneTreei | ENSGT00940000156131 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR008366, NFAT IPR008967, p53-like_TF_DNA-bd IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
H3BRS1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XLDDRRPITL CVCVRARVCD LEPDDCASIY IFNVDPPPST LTTPLCLPHH
60 70 80 90 100
GLPSHSSVLS PSFQLQSHKN YEGTCEIPES KYSPLGGPKP FECPSIQITS
110 120 130 140 150
ISPNCHQELD AHEDDLQIND PEREFLERPS RDHLYLPLEP SYRESSLSPS
160 170 180 190 200
PASSISSRSW FSDASSCESL SHIYDDVDSE LNEAAARFTL GSPLTSPGGS
210 220 230 240 250
PGGCPGEETW HQQYGLGHSL SPRQSPCHSP RSSVTDENWL SPRPASGPSS
260 270 280 290 300
RPTSPCGKRR HSSAEVCYAG SLSPHHSPVP SPGHSPRGSV TEDTWLNASV
310 320 330 340 350
HGGSGLGPAV FPFQYCVETD IPLKTRKTSE DQAAILPGKL ELCSDDQGSL
360 370 380 390 400
SPARETSIDD GLGSQYPLKK DSCGDQFLSV PSPFTWSKPK PGHTPIFRTS
410 420 430 440 450
SLPPLDWPLP AHFGQCELKI EVQPKTHHRA HYETEGSRGA VKASTGGHPV
460 470 480 490 500
VKLLGYNEKP INLQMFIGTA DDRYLRPHAF YQVHRITGKT VATASQEIII
510 520 530 540 550
ASTKVLEIPL LPENNMSASI DCAGILKLRN SDIELRKGET DIGRKNTRVR
560 570 580 590 600
LVFRVHIPQP SGKVLSLQIA SIPVECSQRS AQELPHIEKY SINSCSVNGG
610 620 630 640 650
HEMVVTGSNF LPESKIIFLE KGQDGRPQWE VEGKIIREKC QGAHIVLEVP
660 670 680 690 700
PYHNPAVTAA VQVHFYLCNG KRKKSQSQRF TYTPVLMKQE HREEIDLSSV
710 720 730 740 750
PSLPVPHPAQ TQRPSSDSGC SHDSVLSGQR SLICSIPQTY ASMVTSSHLP
760 770 780 790 800
QLQCRDESVS KEQHMIPSPI VHQPFQVTPT PPVGSSYQPM QTNVVYNGPT
810 820 830 840 850
CLPINAASSQ EFDSVLFQQD ATLSGLVNLG CQPLSSIPFH SSNSGSTGHL
860 870 880 890 900
LAHTPHSVHT LPHLQSMGYH CSNTGQRSLS SPVADQITGQ PSSQLQPITY
910 920 930 940 950
GPSHSGSATT ASPAASHPLA SSPLSGPPSP QLQPMPYQSP SSGTASSPSP
960 970 980 990 1000
ATRMHSGQHS TQAQSTGQGG LSAPSSLICH SLCDPASFPP DGATVSIKPE
1010 1020 1030 1040 1050
PEDREPNFAT IGLQDITLDD VNEIIGRDMS QISVSQGAGV SRQAPLPSPE
1060
SLDLGRSDGL
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ12968 | NFAC3_HUMAN | Nuclear factor of activated T-cells... | NFATC3 NFAT4 | 1,075 | Annotation score: | ||
I3L3K7 | I3L3K7_HUMAN | Nuclear factor of-activated T-cells... | NFATC3 | 1,047 | Annotation score: | ||
H3BR83 | H3BR83_HUMAN | Nuclear factor of-activated T-cells... | NFATC3 | 1,053 | Annotation score: | ||
H3BU30 | H3BU30_HUMAN | Nuclear factor of-activated T-cells... | NFATC3 | 167 | Annotation score: | ||
F8VPH9 | F8VPH9_HUMAN | Nuclear factor of-activated T-cells... | NFATC3 | 38 | Annotation score: | ||
H3BRM3 | H3BRM3_HUMAN | Nuclear factor of-activated T-cells... | NFATC3 | 41 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC020978 Genomic DNA No translation available. AC130462 Genomic DNA No translation available. KF456209 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000570212; ENSP00000456379; ENSG00000072736 |
UCSCi | uc059wdd.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC020978 Genomic DNA No translation available. AC130462 Genomic DNA No translation available. KF456209 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | H3BRS1 |
PeptideAtlasi | H3BRS1 |
PRIDEi | H3BRS1 |
ProteomicsDBi | 42148 |
Protocols and materials databases
Antibodypediai | 3861, 294 antibodies |
Genome annotation databases
Ensembli | ENST00000570212; ENSP00000456379; ENSG00000072736 |
UCSCi | uc059wdd.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000072736.18 |
HGNCi | HGNC:7777, NFATC3 |
OpenTargetsi | ENSG00000072736 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156131 |
Miscellaneous databases
ChiTaRSi | NFATC3, human |
Gene expression databases
Bgeei | ENSG00000072736, Expressed in leukocyte and 227 other tissues |
ExpressionAtlasi | H3BRS1, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR008366, NFAT IPR008967, p53-like_TF_DNA-bd IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H3BRS1_HUMAN | |
Accessioni | H3BRS1Primary (citable) accession number: H3BRS1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | July 11, 2012 | |
Last modified: | December 2, 2020 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |