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Protein

Sulfhydryl oxidase

Gene

GFER

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.UniRule annotation

Cofactori

FADUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidaseUniRule annotation (EC:1.8.3.2UniRule annotation)
Gene namesi
Name:GFERImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000127554.12
HGNCiHGNC:4236 GFER

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127554

PTM / Processingi

Proteomic databases

MaxQBiH3BRD2
PeptideAtlasiH3BRD2
PRIDEiH3BRD2

Expressioni

Gene expression databases

BgeeiENSG00000127554 Expressed in 172 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiH3BRD2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH3BRD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 139ERV/ALR sulfhydryl oxidaseInterPro annotationAdd BLAST58

Phylogenomic databases

eggNOGiKOG3355 Eukaryota
COG5054 LUCA
GeneTreeiENSGT00390000001979

Family and domain databases

Gene3Di1.20.120.310, 1 hit
InterProiView protein in InterPro
IPR036774 ERV/ALR_sulphydryl_oxid_sf
IPR017905 ERV/ALR_sulphydryl_oxidase
PfamiView protein in Pfam
PF04777 Evr1_Alr, 1 hit
SUPFAMiSSF69000 SSF69000, 1 hit
PROSITEiView protein in PROSITE
PS51324 ERV_ALR, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

H3BRD2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NLFFLPGGAR SEMMDDLATD ARGRGAGRRD AAASASTPAQ APTSDSPVAE
60 70 80 90 100
DASRRRPCRA CVDFKTWMRT QQKRDTKFRE DCPPDREELG RHSWAVLHTL
110 120 130
AAYYPDLPTP EQQQDMAQFI HLFSKFYPCE ECAEDLRKR
Length:139
Mass (Da):15,796
Last modified:April 18, 2012 - v1
Checksum:iA4F3F47705A11776
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P55789ALR_HUMAN
FAD-linked sulfhydryl oxidase ALR
GFER ALR, HERV1, HPO
205Annotation score:
H3BQQ4H3BQQ4_HUMAN
Sulfhydryl oxidase
GFER hCG_42694
130Annotation score:
H3BRW3H3BRW3_HUMAN
FAD-linked sulfhydryl oxidase ALR
GFER
109Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005606 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000561710; ENSP00000456189; ENSG00000127554
UCSCiuc059pee.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005606 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH3BRD2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH3BRD2
PeptideAtlasiH3BRD2
PRIDEiH3BRD2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000561710; ENSP00000456189; ENSG00000127554
UCSCiuc059pee.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000127554.12
HGNCiHGNC:4236 GFER
OpenTargetsiENSG00000127554
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3355 Eukaryota
COG5054 LUCA
GeneTreeiENSGT00390000001979

Gene expression databases

BgeeiENSG00000127554 Expressed in 172 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiH3BRD2 baseline and differential

Family and domain databases

Gene3Di1.20.120.310, 1 hit
InterProiView protein in InterPro
IPR036774 ERV/ALR_sulphydryl_oxid_sf
IPR017905 ERV/ALR_sulphydryl_oxidase
PfamiView protein in Pfam
PF04777 Evr1_Alr, 1 hit
SUPFAMiSSF69000 SSF69000, 1 hit
PROSITEiView protein in PROSITE
PS51324 ERV_ALR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH3BRD2_HUMAN
AccessioniPrimary (citable) accession number: H3BRD2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 12, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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